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Novel Neuroprotective Strategy for Treating Traumatic Brain Injury

Details

Project TitleNovel Neuroprotective Strategy for Treating Traumatic Brain Injury
Track Code15016
Websitehttps://www.ohio.edu/research/tto/technologies/loader.cfm?csModule=security/getfile&PageID=2972177
Short Description
Abstract

Overview

Traumatic brain injury (TBI) is a significant medical issue, costing the US healthcare system around $50 billion dollars each year1.  Symptoms range from mild and can completely resolve, to severe, causing long-lasting limitations in social, behavioral, physical, and cognitive abilities.  The CDC estimates that in 2010, TBI accounted for approximately 2.5 million emergency department visits, hospitalizations and deaths in the US.  The Department of Defense has reported that between 2000 and 2011, over 235,000 service members were diagnosed with TBI2.  

Above: Animals subjected to TBI (Image 1) were then treated with regular physiological saline perfusion at pH 7.4 (Image 2) or hypertonic saline = 20% glucose at pH 4.3 + CaEDTA (Image 3). Animals treated with physiological saline experienced secondary injury in addition to the primary impact injury. Acidic saline with CaEDTA was able to limit brain injury to the primary impact area.

When TBI occurs, free ions accumulate in neurons and cells due to the acidic environment in the impacted area of the brain.  Hypertonic saline is often used to decrease intracranial pressure by reducing tissue swelling.  As a result of the saline wash, the pH of the injured area is corrected and the free ions precipitate, causing neuron and cell death.  The solution developed by Dr. Yang Li is formulated to remove excess ions, preventing neuron and cell death and reducing the likelihood of secondary brain damage beyond the immediate physical injury.

Commercial Application

This solution is designed to be utilized as a supportive treatment for TBI, in combination with surgery to remove debris and swollen tissue.  The injured brain area will be washed or covered with acidic saline containing a metal ion chelator to prevent secondary brain damage.   

Benefits

  • Therapy minimizes secondary damage after TBI
  • Chelation therapy, including calcium disodium EDTA and dimercaptosuccinic acid, is an accepted treatment method for removing metals from the body

References

1Traumatic Brain Injury. http://www.aans.org/patient%20information/conditions%20and%20treatments/traumatic%20brain%20injury.aspx

2Traumatic Brain Injury In the United States: Epidemiology and Rehabilitation. https://www.cdc.gov/traumaticbraininjury/pubs/congress_epi_rehab.html

 
TagsTraumatic Brain Injury (TBI); Chelation therapy; Hypertonic saline ; Secondary brain damage;
 
Posted DateOct 11, 2017 7:19 PM

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