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Welcome to the AUTM Global Technology Portal, where you can easily find the latest university technologies available for licensing worldwide.

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Ohio State University

Details

NameOhio State University
Group TypeVenture Fund
URLNone

Projects

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Page of 14
Project Treatment of Multiple Sclerosis with small molecule IL-6/STAT3 inhibitors

The Need

Multiple Sclerosis (MS), an unpredictable and disabling autoimmune disease affecting the central nervous

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Primary: Ohio State University
Date posted: Oct 21, 2017
Project Antitumor Arylnaphthalene Lignan Glycosides

The Need

Nearly 1 in 6 deaths worldwide are from cancer. Although significant advancements have been made

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Primary: Ohio State University
Date posted: Oct 14, 2017
Project Lipid Nanoparticles for Therapeutic Delivery of Anti-miRs and miRs

The Need

MiRNA or miRs are small non-protein coding RNA which are capable of regulating

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Primary: Ohio State University
Date posted: Oct 14, 2017
Project STAT3 Inhibitors and Their Anti-Cancer Usage

The Need

The search for more potent drug delivery candidates for cancer therapy remains a challenge

more
Primary: Ohio State University
Date posted: Oct 14, 2017
Project Productivity model for Advanced Practice Providers

The Need

Physician assistants (PAs) and nurse practitioners (NPs) are referred to as advanced practice

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Primary: Ohio State University
Date posted: Oct 13, 2017
Project Identification of a novel exercise-induced compound in breast milk that improves metabolic health of offspring.

The Need

Type 2 diabetes is a complex disease that arises from a combination of environmental and genetic

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Primary: Ohio State University
Date posted: Oct 13, 2017
Project Dietary Carotenoid Assessment Tool (DCAT).

The Need

Diet is a major variable that contributes to human health and disease risk. Decades

more
Primary: Ohio State University
Date posted: Oct 12, 2017
Project A novel STK1-targeted small molecule as an "antibiotic resistance breaker" against multi-drug-resistant Staphylococcus aureus

The Need

Highly pathogenic and multidrug-resistant Staphylococcus aureus (MDRSA) encompasses methicillin-resistant strains of S. aureus that

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Primary: Ohio State University
Date posted: Oct 6, 2017
Project Galnac drug conjugates to treat liver diseases

The Need

Liver diseases are a major cause of morbidity and mortality in the United States

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Primary: Ohio State University
Date posted: Oct 3, 2017
Project A New Agrobacterium Strain for Plant Transformation

The Need

Agrobacterium is a Gram-negative, plant pathogenic soil bacterium that has the unique capacity tomore

The Need

Agrobacterium is a Gram-negative, plant pathogenic soil bacterium that has the unique capacity to transfer some of its DNA to specific cells in the plant host. Over the past 35 years, this bacterium has played a central role in basic scientific research and applied agricultural biotechnology in the production of transgenic plants. While there are many different bacterial strains of Agrobacterium that exist in nature, only a few different strains are widely used in most laboratories and no strains have been isolated, selected and disarmed based on their presence in the field soil where a specific crop has been grown. Although efficiencies of Agrobacterium-mediated transformation have improved tremendously over the past 30 years, further improvements are still needed. Transformation of soybean using Agrobacterium remains challenging and is best described as consistent but inefficient. A new soybean-derived Agrobacterium strain may lead to efficiencies that have never before been achievable, using known strains that were previously isolated from cherry or cucumber. There remains a significant need for improved or novel strains of Agrobacterium capable of effectively and efficiently transforming soybean.

The Technology

Researchers at The Ohio State University led by Dr. John Finer have discovered "JTND", a novel Agrobacterium strain isolated from the soil in a soybean field that possesses enhanced transformation attributes for soybean. Most laboratories consistently use only a select few number of Agrobacterium strains for transformation of most plants including soybean, and the most common strain used is EHA105, which was found associated with a cherry tree in New York. However, the newly isolated strain JTND was found in a soybean field in North Dakota and gives a 10-100-fold improvement in soybean transformation over EHA105. Transformation efficiency was determined by directly counting the numbers of transformed plant cells using the GFP reporter gene in different strains. The JTND strain and the disarmed SBHT strain derived from JTND could be extremely useful to all laboratories that undertake soybean transformation studies. This remarkable 10-100-fold increase would save both time and effort in the production and evaluation of transgenic crops.

Commercial Applications

  • Agriculture biotechnology
  • Plant Transgenics

Benefits/ Advantages

  • Increased efficiency
  • A 10-100-fold improvement in soybean transformation over EHA105

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Primary: Ohio State University
Date posted: Aug 22, 2017