|Organization Name||Wisconsin Alumni Research Foundation (WARF)|
|Institutional ID Number||P100077US02|
|Technology Tags or Keywords|
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a vitamin D analog that is potentially useful as a chemotherapeutic agent.
|Technology page URL||http://www.warf.org/technologies.jsp?ipnumber=P100077US02|
|Detailed Technology Description||
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone mobilizes calcium from bones and increases intestinal absorption of dietary calcium. Effective therapeutic concentrations can lead to hypercalcemia; a condition characterized by elevated blood calcium levels, alterations in mental status, muscle weakness and calcification of soft tissues and organs such as the heart and kidneys. Therefore, a need exists for non-calcemic compounds that provide desirable therapeutic effects without causing dose-limiting hypercalcemia.
|TTO homepage URL||http://www.warf.org|
|URL to link to documents, images, videos, etc.||--|