Novel protein useful for increasing resistance to a virus

Organization Name	Columbia Tech Ventures
Institutional ID Number	9967
Technology Tags or Keywords	cardiovascular coronary artery implantation Personalized healthcare retenosis stent Y-27632
Summary	This invention described a new isolated zinc finger protein (ZAP) useful for increasing resistance to a virus in a subject or mammalian cells. This invention provides compositions of the protein and methods of producing it in a mammalian cell. ...
Technology Benefit	It can be administered by different routes, such as oral, subcutaneous routes et al, which gives a lot of flexibility This ZAP protein is sufficient on its own to induce an antivirus state without apparent effect on cell viability or physiology
Technology Applications	It can be developed into viral replication inhibitor to increase resistance to a virus in a subject This invention provides screening tool for identifying new genes/agents with potent antiviral activity
Technology page URL	http://techventures.columbia.edu
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Additional Information	Track Code P9967 IR # 1300 Summary Lead Inventors: Stephen P. Goff, Ph.D. Problem or Unmet Need: Virus infections are very common infective diseases and exceptionally widespread. The existing approaches to fight severe virus infections do not generate expected cure rates or quality of life. In addition, current approaches have some side effects, such as drastic shutoff of host function. Therefore, there is unmet need in the market for new innovative products. This invention identified a new protein that could inhibit virus replication and increase resistance to virus infection, which could aid in future anti-virus protein therapy. This invention described a new isolated zinc finger protein (ZAP) useful for increasing resistance to a virus in a subject or mammalian cells. This invention provides compositions of the protein and methods of producing it in a mammalian cell. This invention also provides method of determining whether an agent increases expression of this ZAP protein in a mammalian cell. In addition, it gives method of determining whether an agent increases resistance to a virus in a mammalian cell. Publications Gao G, Guo X, Goff SP. Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. Science. 297(5587):1703-1706 (2002) Web Links USPTO: US20070025967A1 Inquiry Peter Golikov Columbia Technology Ventures Tel: (212) 854-8444 Email: TechTransfer@columbia.edu

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