|Organization Name||Columbia Tech Ventures|
|Institutional ID Number||9967|
|Technology Tags or Keywords|
This invention described a new isolated zinc finger protein (ZAP) useful for increasing resistance to a virus in a subject or mammalian cells. This invention provides compositions of the protein and methods of producing it in a mammalian cell. ...
|Technology page URL||http://techventures.columbia.edu|
|Detailed Technology Description||
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SummaryLead Inventors: Stephen P. Goff, Ph.D.
Problem or Unmet Need:
Virus infections are very common infective diseases and exceptionally widespread. The existing approaches to fight severe virus infections do not generate expected cure rates or quality of life. In addition, current approaches have some side effects, such as drastic shutoff of host function. Therefore, there is unmet need in the market for new innovative products. This invention identified a new protein that could inhibit virus replication and increase resistance to virus infection, which could aid in future anti-virus protein therapy.
This invention described a new isolated zinc finger protein (ZAP) useful for increasing resistance to a virus in a subject or mammalian cells. This invention provides compositions of the protein and methods of producing it in a mammalian cell. This invention also provides method of determining whether an agent increases expression of this ZAP protein in a mammalian cell. In addition, it gives method of determining whether an agent increases resistance to a virus in a mammalian cell.
PublicationsGao G, Guo X, Goff SP. Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. Science. 297(5587):1703-1706 (2002)
Web LinksUSPTO: US20070025967A1
Columbia Technology Ventures
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