|Organization Name||Columbia Tech Ventures|
|Institutional ID Number||9994|
|Technology Tags or Keywords|
This invention is an improved method for measuring cerebral blood flow and perfusion in a MR scanner with greater sensitivity than current technologies. Instead of applying a steady label to the flowing spins in ASL, a more complex pattern - known as...
|Technology page URL||http://techventures.columbia.edu|
|Detailed Technology Description||
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SummaryLead Inventors: Truman R. Brown, PhD
Problem or Unmet Need:
Cerebral blood flow (CBF) is one of the most important physiological variables in understanding local brain metabolism. By detecting changes in blood flow, regions of the brain with increased blood oxygen requirements can be identified - this is the most frequently used method to estimate changes in neural activation. Previously CBF measurements have used PET, CT or magnetic resonance imaging (MRI) to detect radioactive tracers or radiographic or MR contrast agents administered to the patient intravenously, but these methods are invasive and expensive, and some patients are excluded due to contraindications to the agent.Arterial Spin Labeling (ASL) techniques replace the need for injected contrast agents by using water protons in the plasma as an endogenous MRI tracer, which is both non-invasive and cost effective. However, it is not possible to measure the transit time or temporal distribution from the labeled location with accuracy using these methods, and problems are encountered in diseased brains with decreased blood flow and in areas containing white matter.
This invention is an improved method for measuring cerebral blood flow and perfusion in a MR scanner with greater sensitivity than current technologies. Instead of applying a steady label to the flowing spins in ASL, a more complex pattern - known as pseudo random sequence is used, which provides information on flow times and spatial distribution.
USPTO: US20070282193 A1
Columbia Technology Ventures
Tel: (212) 854-8444