Natural Products for Cancer Therapeutics
Organization: Indiana Univ-Purdue University Indianapolis
Although algorithms and chemistries for developing new therapeutic entities are constantly evolving, none can replicate the path and novelty of natural selection over eons of time. Inventors at the Scripps Institution of Oceanography have engaged their fleet of research ships to cull the oceans for marine organisms from which new compositions are isolated. Using a variety of culture systems, selective fractionation and bioassays, two, distinct classes of compounds, isolated from actinomycetes, have ...
Marine Organism Yields a Patented Family of Antitumor/Antibiotic Compounds
Organization: Indiana Univ-Purdue University Indianapolis
Researchers at the Scripps Institution of Oceanography have discovered a new group of marine actinomycetes that have tentatively been called MAR2. These bacteria produce unique, polyketide-derived macrolides including a series of compounds called marinomycins A-D, which were discovered from the MAR2 strain CNQ-140 (Kwon et al., 2006). These compounds possess potent antibiotic and antitumor properties.
Organization: Indiana Univ-Purdue University Indianapolis
SIO scientists have developed effective methods to cultivate unique marine microorganisms, which are a rich source of bioactive secondary metabolites. Using state of the art methods in microbiology and natural products chemistry, cultures are isolated for use in discovery of new compounds. Pure compounds as well as extract and fraction libraries are stored in a 96-well plate format and are readily available for testing at standardized concentrations.
Marine Organism Yields a Patented Family of Antitumor/Antibiotic Compounds
Organization: University of California, San Diego (UC San Diego)
Researchers at the Scripps Institution of Oceanography have discovered a new group of marine actinomycetes that have tentatively been called MAR2. These bacteria produce unique, polyketide-derived macrolides including a series of compounds called marinomycins A-D, which were discovered from the MAR2 strain CNQ-140 (Kwon et al., 2006). These compounds possess potent antibiotic and antitumor properties.
Natural Products for Cancer Therapeutics
Organization: University of California, San Diego (UC San Diego)
Although algorithms and chemistries for developing new therapeutic entities are constantly evolving, none can replicate the path and novelty of natural selection over eons of time. Inventors at the Scripps Institution of Oceanography have engaged their fleet of research ships to cull the oceans for marine organisms from which new compositions are isolated. Using a variety of culture systems, selective fractionation and bioassays, two, distinct classes of compounds, isolated from actinomycetes, have ...
Novel Small Molecules that Target Cancer Stem Cells for the Treatment of Cancer
Organization: University of California, Los Angeles (UCLA)
Professor Michael Jung from the Department of Chemistry and Biochemistry, Professor Richard Pietras from the Department of Medicine, and colleagues at UCLA have recently synthesized and evaluated a series of unique PTL derivatives. A number of these compounds exhibit (i) improved aqueous solubility as well as (ii) improved in vitro cell killing relative to the native forms of PTL and DMAPT. Furthermore, these new derivatives exhibit a synergistic cell killing effect when combined with existing approved chemotherapeutic agents. ...
Organization: University of California, San Diego (UC San Diego)
SIO scientists have developed effective methods to cultivate unique marine microorganisms, which are a rich source of bioactive secondary metabolites. Using state of the art methods in microbiology and natural products chemistry, cultures are isolated for use in discovery of new compounds. Pure compounds as well as extract and fraction libraries are stored in a 96-well plate format and are readily available for testing at standardized concentrations.
