Tag Name: Genomics/Proteomics

Technology

• Vaccinia Virus Vectors and Methods to Prevent the Pathology Caused by Infectious Agents

  Organization: Arizona Tech Enterprises (AzTE)

  The vaccinia virus, when used for various clinical applications, is quite versatile and potentially very beneficial to human health. In addition to its utilization as a smallpox vaccine, the vaccinia virus is extensively used as an effective expression vector since it is easy to isolate, can accommodate vast amounts of exogenous DNA and has a wide host range. Foreign genetic material, which is incorporated into the vaccinia genome, may encode for antigens and other useful molecules, including anticancer agents. Unfortunately, while the ...

• Systematic Identification of Essential Genes by In Vitro Transponson Mutagenesis

  Organization: Tufts University

• Design of cis/trans Engineered Riboregulators

  Organization: Boston University

• Enter and Destroy the Biofilm Matrix: Dispersing Bacterial Biofilms with Engineered, Enzymatically Active Bacteriophage

  Organization: Boston University

• Automated Workstation for Data Acquisition and Perfusion Control in Oocytel Electrophysiology

  Organization: Boston University

• Methods and Device for Tuning Multiplexed Markers for Disease Assay

  Organization: Arizona Tech Enterprises (AzTE)

  A single biomarker is often insufficient to identify a given disease with both sensitivity and specificity. In such cases, one or more additional tests for other biomarkers are used in order to accurately diagnose the disease. The disadvantage of this process is that multiple sensors, wells, platforms, and/or labels are frequently required to measure the different biomarkers. Researchers at the School of Biological & Health Systems Engineering of Arizona State University and the Biodesign Institute have developed a modified ...

• Expanding ChIP’s Reach: Automating ChIP for High-throughput Screens and ChIP Controls to Increase Sample Comparability

  Organization: Broad Institute

• Gene-Expression Signatures that Identify Cirrhosis Patients "At Risk" for Liver Cancer and Predict the Probability of HCC Recurrence Following Early-Stage Diagnosis and Resection

  Organization: Broad Institute

• Novel, Clinically Validated Biomarkers for Early Diagnosis of Myocardial Infarction

  Organization: Broad Institute

• Fosill and ShARC: Two New Methods for Making Long-Distance (~40kb) Jumping Libraries for High-Quality Next Generation Genome Sequencing

  Organization: Broad Institute

• Targets including YAP1 for Anti-fungal Drug Discovery and Therapy

  Organization: Worcester Polytechnic Institute

• High Efficiency Transfection of Cells with Nucleic Acid Constructs, Proteins and Small Molecules

  Organization: Arizona Tech Enterprises (AzTE)

  Genetic intervention techniques, such as gene silencing and gene expression, are important in many facets of healthcare and research. However, a major challenge in the above applications is the efficient transfection of primary cells lines such as neurons. Non-viral transfection methods are widely used in both in vitro and in vivo systems; however, these methods are less effective in neuronal cells. Improved transfection strategies that are consistent, highly efficient, and which preserve cell viability would be a boon to many fields of ...

• Root Specific Promoter for the Development of Transgenic Plants

  Organization: Arizona Tech Enterprises (AzTE)

  This invention provides a novel promoter useful for obtaining extremely high levels of cellular transcription and translation. As a result, production of high levels of heterologous proteins is possible. The significance of this product lies in both the strength and the specificity of the promoter for transgene expression in plants and plant tissue as compared to all existing technologies. Research has demonstrated these outcomes by monitoring the expression of heterologous jellyfish green fluorescence protein (GFP) using novel ...

• Micro-Vacuum Instrument for Fluid Manipulation

  Organization: Arizona Tech Enterprises (AzTE)

  Liquid reagent manipulation is a critical component of many platforms; including microarrays, ink printing, various microfluidic platforms, cell and other biological manipulation. Many of these systems use vacuum to control the fluid movement, often in conjunction with small pressures. Current systems are limited in how small of a vacuum they can achieve in order to manipulate their fluids/biologicals. There is a need for a simple system for liquid reagent control such that smaller, more precise volumes can be utilized. Researchers at ...

• Vacuum Assisted Liquid Dispensing System

  Organization: Arizona Tech Enterprises (AzTE)

  Precise control of fluid delivery is important in a variety of industries including microarrays, sensors, printing and many more. Current systems for dispensing fluids implement contact and non-contact tips. Non-contact tips utilize piezoelectric or diaphragm means and contact tips often utilize capillary forces. Both contact and non-contact tips have the disadvantage of being limited in their droplet size and in the selection of viscosity fluids from which they can use.. Researchers at the Biodesign Institute of Arizona State ...

• Prevotella and Coprococcus as human gut health enhancers. Specific case example: Autism.

  Organization: Arizona Tech Enterprises (AzTE)

  The human gut hosts millions of bacteria, which help balance the immune system, digest food, produce vitamins and promote gastrointestinal (GI) motility. Imbalances in the gut microbiome may contribute to immune and neurological disorders as well as GI problems. Given the crucial role of gut microorganisms in maintaining GI health and the increasing evidence of GI problems in autistic children, it is highly likely that there is a link between autism and gut microbiota. While there have been reports to identify and characterize ...