Recombinant Phycobiliprotein-based Target-specific Fluorescent Labels
Organization: University of California, Berkeley (UC Berkeley)
Organization: University of California, Berkeley (UC Berkeley)
Mouse Monoclonal Antibodies To Mouse Ctla-4
Organization: University of California, Berkeley (UC Berkeley)
Reagents To Study The Structure And Function Of The Prototype Map Kinase Scaffold Protein, Ste5
Organization: University of California, Berkeley (UC Berkeley)
Activated Form Of Human Dicer With Enhanced Activity
Organization: University of California, Berkeley (UC Berkeley)
Multi-chromophore Fluorescent Probes Using Dna Intercalation Complexes
Organization: University of California, Berkeley (UC Berkeley)
A Site-specific Endonuclease For The Cleavage Of Very Large Dna Molecules
Organization: University of California, Berkeley (UC Berkeley)
Organization: University of California, Berkeley (UC Berkeley)
Methods to Alter ER Stress Signaling
Organization: University of Michigan
Background The endoplasmic reticulum (ER) is a cellular organelle specialized for protein folding and assembly of membrane proteins and of proteins destined for trafficking to lysosomes and the extracellular space. Unfolded protein response (UPR) exists in cells to detect unfolded protein in the ER lumen, and transduce a signal(s) across the ER membrane to activate transcription of selective genes in the nucleus. While the molecular mechanisms signaling the yeast UPR are well characterized, the mechanisms signaling the UPR in mammalian cells ...
Methods and Compositions for High-Resolution Micropatterning for Cell Culture
Organization: University of California, San Francisco (UCSF)
One barrier to research productivity in assaying cells in culture is the disorganized distribution and random arrangement of cells that can make precise single cell analyses difficult to perform. The challenge is to locate and distinguish individual cells and for some cell types, this includes a specific and consistent orientation, shape and position of the cell. Furthermore, current micropatterning techniques do not produce reliable patterns and often these patterns can be maintained in culture for only a few days. This platform ...
Antigen for Pax2 Monoclonal Antibody Generation
Organization: Indiana Univ-Purdue University Indianapolis
UM File # 3764BackgroundPax-2 belongs to a family of homebox genes that contain a paired domain, which binds to the DNA to initiate transcription of specific genes. As the first known kidney-specific gene to be expressed in the pronephros of the mouse embryo, Pax-2 is indispensable for ureteric bud development. Recent, scientists have found that activation of Pax-2 can contribute to a variety of renal diseases. Thus, Pax-2 can be a potential therapeutic target for renal diseases.Technology DescriptionThe C-terminal of Pax-2 is the ...
Optical Sensors for the Detection of Nitric Oxide
Organization: Indiana Univ-Purdue University Indianapolis
UM File # 1755BackgroundNitric oxide plays an essential role a variety of biological processes including vasodilation and as neurotransmitters in the central and peripheral nervous systems. Given the growing importance of the molecule, there have been a number of attempts to develop means to measure cellular levels of nitric oxide. Approaches include fiber optic nitric oxide chemiluminescent sensor and sol-gel-based sensors. To date, these sensors have been limited by their slow response, large size, and inability for dynamic ...
Thermo-active SIV Reverse Transcriptase
Organization: Indiana Univ-Purdue University Indianapolis
The laboratories of Dr. Baek Kim have previously reported that reverse transcriptase (RT) activity becomes less error prone running reactions at 55 degrees C as opposed to 37 degrees C. In order to apply a high thermal reaction condition, RTs that are heat stable or RTs that have higher activity at high temperatures are required. Dr. Kim has discovered and characterized a heat stable reverse transcriptase enzyme that can work efficiently at high reaction temperatures. Dr. Kim's simian derived heat stable reverse transcriptase has exhibited ...
Organization: Indiana Univ-Purdue University Indianapolis
One of the greatest needs in the field of cancer treatment is a method or reagent that selectively enhances the killing of cancer cells. The most frequently used treatment methods for cancer patients, exposure to radiation and/or chemotherapy, kill healthy cells as effectively, or even more effectively, than they kill cancer cells. Therefore dose-limiting toxicity is a serious issue with these treatments. This technology demonstrates that specific caspase inhibitors can selectively target and kill cancer cells without exerting toxicity on ...
Organization: Stanford University
Mass Spectrometry-based Particle and Cell Separation
Organization: Stanford University
Degradable Detergents for Mass Spectrometry
Organization: Stanford University
Self-luminescing BRET-FRET NIR nanoparticles for in vivo imaging
Organization: Stanford University
Reagents for Epigenetic Research
Organization: Stanford University
Chromatin and Epigenetic Research
Organization: Stanford University
Mass Spectrometry-based Particle and Cell Separation
Organization: Stanford University
Degradable Detergents for Mass Spectrometry
Organization: Stanford University
Self-luminescing BRET-FRET NIR nanoparticles for in vivo imaging
Organization: Stanford University
Reagents for Epigenetic Research
Organization: Stanford University
Chromatin and Epigenetic Research
RNA Binding Fluorochrome: Fluoro Nissl Green
Organization: University of California, Los Angeles (UCLA)
An efficient chemical synthesis has been developed for a new low molecular weight compound, Fluoro Nissl Green, which selectively binds RNA in vitro and in vivo in the presence of DNA. The compound is highly fluorescent with an emission at 510 nm and it has been purified and well characterized. Unlike other known RNA-binding compounds, it does not significantly bind to DNA. Unlike antibodies or oligonucleotide sequences targeted for detection of nucleic acids, it is inexpensive to prepare, stable tohydrolysis and is not limited by sequence ...
