Tag Name: mouse models

Technology

• Mice overexpressing Dgat1 in muscle tissue (MCK-Dgat1 mice)

  Organization: Columbia Tech Ventures

• Cerebellar motor learning mice (HCN1 flox mice- Knock-in)

  Organization: Columbia Tech Ventures

• Mice bearing a defective cerebellum (B6;129-Hcn1tm2Kndl/ J mice- targeted mutation, knockout)

  Organization: Columbia Tech Ventures

• Cells useful in evaluating cardiac transplantation and regeneration techniques (AC16 cells)

  Organization: Columbia Tech Ventures

• Bone development and organismal metabolism mice (ATF4 Knock out mice)

  Organization: Columbia Tech Ventures

• Lymphoid and mammary development model mice (TRE2-Axin-GFP mice)

  Organization: Columbia Tech Ventures

• Cell lineage tracking mice (Rosa26-CFP mice)

  Organization: Columbia Tech Ventures

• Ureteric lineage tracking mice (Hox7-EGFP mice)

  Organization: Columbia Tech Ventures

• Diffuse Large B- Cell Lymphoma (DLBCL)-BCL6 mouse

  Organization: Columbia Tech Ventures

• Lipotoxic cardiomyopathy model mice (LPL-GPI mice)

  Organization: Columbia Tech Ventures

• Mice expressing LPL in endothelial cells (Tie2 LPL mice)

  Organization: Columbia Tech Ventures

• Cardiac lipotoxicity model mice (MHC PPARgamma mice)

  Organization: Columbia Tech Ventures

• Mice overexpressing Dgat1 in cardiac muscle tissue (MHC-Dgat1 mice)

  Organization: Columbia Tech Ventures

• Forebrain neuron-specific inducible gene expression mice (CamKIIa-tTA mice)

  Organization: Columbia Tech Ventures

• Bone-specific leptin-dependent sympathetic regulation deficient mice (Beta 2 Adrenergic Receptor conditional KO mice)

  Organization: Columbia Tech Ventures

• Insulin signaling deficient mice (Insulin receptor Knock-out mice)

  Organization: Columbia Tech Ventures

• Arterial calcification model mice (Mgp KO mice)

  Organization: Columbia Tech Ventures

• Tumor suppressor deficient mice (PTEN mutant mice)

  Organization: Columbia Tech Ventures

• Interferon signaling mice (STAT2 Knock-out mice)

  Organization: Columbia Tech Ventures

• STAT3-flox mice

  Organization: Columbia Tech Ventures

• Prostate adenocarcinoma model cells (CASP1-1)

  Organization: Columbia Tech Ventures

• Yeast with rapid growth rate, excellent transformation ability and outstanding genetic characteristics (W303-related yeast (W1588-4C))

  Organization: Columbia Tech Ventures

• Cardiogenesis model cells (Neonatal Rat Reversible Immortalized Primary Cardiomyocytes)

  Organization: Columbia Tech Ventures

• High-throughput fluorescent screening cells (HB9-GFP (HBG3) ESC)

  Organization: Columbia Tech Ventures

• BIO-003 - CANCER - Serum Biomarker System for Basic and Pre-Clinical Research in Genetically Engineered Mouse Models of Prostate Cancer

  Organization: WORLDiscoveries - University of Western Ontario

  This invention concerns identification of the first serum tumour marker for monitoring the initiation and progression of prostate cancer (CaP) in animal models. Current prostate cancer (CaP) research in both basic and pre-clinical trial studies employ genetically engineered (GE) mouse models, since CaP does not occur naturally in rodents. Widespread adoption of these models has thus far been limited by the stochastic and often invisible nature of murine GE-CaPs, the requirement for the treatment of large cohorts of mice for autopsy ...

• Genetically Engineered Mice Lacking a Tumor Suppressor Gene in the CNS

  Organization: University of California, Los Angeles (UCLA)

  To overcome the early embryonic lethal phenotype in PTEN(-/-) mice and to study the roles of PTEN in embryonic development, adult tissue function, and tumorigenesis, researchers at UCLA have generated a knockout mouse model with the PTEN gene functionally deleted in neural stem cells. The mouse model can be used in the following applications: 1) preclinical screening for compounds with activities that target the PTEN-controlled signaling pathways in treating cancer and other neurological abnormalities; 2) stemcell research for ...

• Ptgs2 (Cyclooxygenase-2) Conditional Knockout Mouse

  Organization: University of California, Los Angeles (UCLA)

  Prostaglandin-endoperoxide synthase 2 (Ptgs2, also known as Cyclooxygenase-2 or Cox-2) is an enzyme involved in the biosynthesis of prostanoids. Aberrant Ptgs2 expression plays major causal and modulatory roles in various cancers, neurodegenerative diseases, and chronic and acute inflammation conditions. Researchers at UCLA have developed a transgenic mouse model that results in conditional deletion of the Ptgs2 gene using Cre/loxP technology. This innovation allows the investigation of Ptgs2 function in specific tissues or at various ...