Tag Name: imaging

Capability

• Imaging

  Organization: Case Western Reserve University

  Case Center for Imaging Research (CCIR) is a joint venture between Case Western Reserve University School of Medicine and University Hospitals of Cleveland. A major part of the CCIR includes state-of-the-art clinical and preclinical research imaging facilities including 4 new multi-nuclear, high-field MRI systems, 4 nuclear imaging systems, and 2 optical imaging systems. The ~9000 sq. foot facility also includes wet labs, conference areas, and additional faculty office space.

• Medical Imaging

  Organization: Mayo Clin

  The Mayo Clinic has a long-standing reputation as a leader in the research and development of imaging modalities including MRI, CT, PET, SPECT and ultrasound. Magnetic Resonance Elastography (MRE) was first conceived at the Mayo Clinic in recent years and holds promise for diagnosing a vast array of medical conditions. Other imaging advancements developed at Mayo include Molecular Breast Imaging (MBI), CT dose reduction, and ultrasound vibrometry. Mayo has a state-of-the-art 40,000 square foot facility, one of the largest in the country, for ...

• Bioengineering and Bioinformatics

  Organization: Methodist Hospital Research Institute

  The department is composed of a multi-disciplinary team of investigators, fellow and staff with expertise in bioinformatics, cheminformatics, computational biology, systems biology, translational neurobiology, bioimaging, drug screening, image computing, medical informatics, and imaging physics. The BBP Core includes three interdisciplinary centers. The Ting Tsung and Wei Fong Chao Center for Bioinformatics Research and Imaging for Neurosciences (BRAIN), which is dedicated to advancing research in neurodegeneration; the Center for ...

• Integrated Systems in Sensing, Imaging, and Communication

  Organization: Michigan Technological University

  Michigan Tech’s electrical and computer engineering researchers are promoting the integration of physical models, device technologies, and signal processing theory for the development of information systems with applications in sensing, imaging, and communications. Recent projects include the on-going development of nanoscale technologies, advanced RFID tags for the U.S. Army, and passive radar technology. Over the past five years, research efforts have been supported by an excess of $10 million in awarded funds from industries and grants.

• Oregon National Primate Research Center

  Organization: Oregon Health & Science University

  As one of the eight NIH-supported National Primate Research Centers in the United States, the Oregon National Primate Research Center (ONPRC) provides Nonhuman Primate (NHP) resources for the very best scientific programs. ONPRC research is carried out in the three scientific divisions, which include Neuroscience, Reproductive Sciences, and Pathobiology & Immunology. In addition, the center offers molecular biology, immunology, surgical and imaging capabilities on site. Having received over 54 million in awards in fiscal year 2010, the ONPRC ...

• Oncology

  Organization: University of Pittsburgh

  The University of Pittsburgh Cancer Institute (UPCI) is a National Cancer Institute (NCI)-designated Comprehensive Cancer Center. UPCI and the University of Pittsburgh Medical Center (UPMC) Cancer Centers are internationally recognized for their leadership in cancer prevention, detection, diagnosis, treatment and research. UPMC Cancer Centers treat more than 36,000 new patients each year through a hub-and-satellite network of 37 community-based locations. This network also has enabled UPCI to conduct more than 150 clinical trials to date. ...

• Imaging

  Organization: University of Pittsburgh

  Multidisciplinary collaborations supported by significant federal grants and world-class labs and equipment help position the University of Pittsburgh as a world leader in medical imaging research and technology development. From one of the nation’s most advanced magnetic resonance research centers and a PET facility supported by a $17 million grant from the Bill & Melinda Gates Foundation, to multidisciplinary translational research in ultrasound molecular imaging, proactive clinical leadership from one of the largest medical centers in the ...

• Nano-optics

  Organization: University of Pittsburgh

  Nano-optics technology can shrink a table-top-size instrument into finger nail size and yet overcome the limits of conventional optics. This platform technology is expected to revolutionize various areas such as information technology, health care, and energy, enabling portable/wearable/disposable instruments for spectroscopy and imaging, as well as high-efficiency photovoltaic devices. The nano-optics program at Pitt is one of the focused interdisciplinary research efforts conducted at the Petersen Institute of NanoScience and Engineering ...

• Biomedical Engineering

  Organization: University of Virginia

  The University of Virginia biomedical engineering program is regularly recognized among the top 15 programs in the country (U.S. News & World Report) and has received a number of awards for its research, educational and translational activities, including the Wallace H. Coulter Foundation Translational Partners Award and the National Science Foundation’s “Partnerships for Innovation” award. For more information: www.bme.virginia.edu.

• Targeted Cancer Therapeutics and Imaging

  Organization: University of Virginia

  Ranked among the nation’s top cancer centers (U.S. News & World Report), the University of Virginia Cancer Center is a National Cancer Institute Designated Cancer Center with more than 75 million dollars in funded research. The center includes nearly 200 investigators from 13 departments within the University’s School of Medicine and College of Arts & Sciences. The cancer research program is organized around research programs in cancer cell signaling, endocrinology/women’s oncology, immunology and immunotherapy, structural and chemical ...

• Cardiovascular Research

  Organization: University of Virginia

  More than 100 faculty members with educational backgrounds and research experience from all around the world contribute to the cardiovascular research community at the University of Virginia, where clinicians and researchers across several medical and engineering disciplines are developing cardiovascular therapies, devices, imaging techniques and other tools to advance the field and improve patient care. The University’s Robert M. Berne Cardiovascular Research Center at the University of Virginia supports interdisciplinary research in basic, ...

• Confocal and Conventional Microscopy Core

  Organization: University of Rochester

  The URMC Confocal and Conventional Microscopy Core strives to provide UR researchers the ability to obtain high quality imaging data using state-of-the-art microscopy instruments. The Core also aims to be one of the information hubs for UR resources centering around histological processing, imaging, and image processing and to serve as a conduit for communication between imaging researchers on campus.
  
  The Confocal and Conventional Microscopy Core provides Medical Center researchers access to high-end confocal microscopy as well as more ...

• Rochester Center for Brain Imaging (RCBI)

  Organization: University of Rochester

  The Rochester Center for Brain Imaging (RCBI) is a research facility offering a state-of-the-art 3T magnet for the purpose of conducting investigations using magnetic resonance imaging (MRI) to researchers from the University of Rochester, neighboring institutions, and the science and technology industries.
  
  The primary purpose of the Center is to gather functional MRI data from the normal adult brain while volunteers perform a variety of tasks. The Center is also able to provide structural images of any part of the human body, and ...

• Rochester Center for Brain Imaging (RCBI)

  Organization: University of Rochester

  The Rochester Center for Brain Imaging (RCBI) is a research facility offering a state-of-the-art 3T magnet for the purpose of conducting investigations using magnetic resonance imaging (MRI) to researchers from the University of Rochester, neighboring institutions, and the science and technology industries.
  
  The primary purpose of the Center is to gather functional MRI data from the normal adult brain while volunteers perform a variety of tasks. The Center is also able to provide structural images of any part of the human body, and ...

Technology

• MASDA (Multi-Element-Amorphous-Silicon-Detector-Array) Real-Time Imager & Dosimeter for Mega-Voltage Photons

  Organization: University of Michigan

• High-Speed Parallel Magnetic Resonance Imaging

  Organization: UWM Research Foundation Inc

  Magnetic resonance imaging (MRI) is a relatively slow imaging technique. Although imaging speeds have increased dramatically over the last two decades, many clinical and research applications, ranging from contrast-enhanced dynamic imaging of cancer to cardiac imaging, require still faster imaging methods. Parallel imaging is an emerging technology to speed up the imaging process using phased array coils. However, parallel imaging usually needs exact knowledge of the coil sensitivities, which cannot be obtained accurately. This invention ...

• Remote Sign Language Interpretation System

  Organization: McGill University

  The Remote Video Interpretation system allows a physician (or other service provider) and deaf patient to face each other and allows a deaf patient to lie on a stretcher while being examined by a physician. The patient's sign language and physician's speech are interpreted at a regional sign language interpretation centre in real time. A video screen and camera are mounted at each end of the stretcher. One camera relays live video of the patient and the other relays live video and audio of the physician to the remote interpreter. The ...

• Reagents For Detection And Imaging Of HIV-1

  Organization: University of California, Los Angeles (UCLA)

  This invention consists of a new family of molecular probes for the detection and imaging of human immunodeficiency virus-type 1 (HIV-1) in infected individuals, animal models, or cultured cells. These new compounds also allow for detection and quantitation of HIV in biological fluids or cell culture media. Moreover, depending on the compound utilized, a number of techniques (e.g. MRI, PET, single photon emission computed tomography (SPECT), and fluorescence at either optical or near-infrared (NIR) wavelengths) can be employed in HIV detection.

• Chemosensors Based on Quantum Dots and Oxazine Compounds

  Organization: University of Miami

  Conventionally, organic dyes are used to image biological samples on the basis of fluorescence microscopy. This technique relies on the injection of a fluorescent organic dye in the sample under analysis, followed by the excitation with light of appropriate wavelength. The incident radiation is absorbed and re-emitted by the fluorescent molecules. Organic dyes, however, have shortcomings such as low absorption coefficients, poor photobleaching resistance, short luminescence lifetimes and lack of flexibility in adjusting the emission ...

• Mechanism to Signal Receptor-Ligand Interactions with Luminescent Quantum Dots

  Organization: University of Miami

  Organic dyes are traditionally used to image biological samples on the basis of fluorescence microscopy. This technique relies on the injection of a fluorescent organic dye in the sample under analysis, followed by the excitation with light of appropriate wavelength. The incident radiation is absorbed and re-emitted by the fluorescent molecules. Organic dyes, however, have shortcomings such as low absorption coefficients, poor photobleaching resistance, short luminescence lifetimes and lack of flexibility in adjusting the emission wavelength. ...

• System and Method for Imaging Tear Film on Ocular Surface

  Organization: University of Miami

  Imaging of a tear film interface between an eye and a contact lens is important in studying contact lens fitting behavior. When OCT imaging is employed to analyze the tear film, one of the two tear film surfaces is typically not recognizable. What is needed is the ability to see both tear film surfaces when studying the tear film interface with OCT instrumentation. The addition of a scattering media is added to a tear film to increase its contrast against the background. The scattering media improves differentiation of optical properties of a ...

• Bifocal OCT System for Imaging Accommodation of the Eye

  Organization: University of Miami

  Accommodation is the process by which the eye increases optical power to maintain a focus on an object near the eyes. The range of accommodation usually declines with age causing farsightedness. Currently, there are no methods that resolve the whole anterior segment, a requirement for studying accommodation. Optical Coherence Tomography may be used to study eye accommodation and develop a treatment for restoring its function if it could provide ultra-long imaging depth, which exceeds existing capabilities of OCT apparatus. To increase imaging ...

• High Numerical Aperature Mobile Telemicroscopy

  Organization: University of California, Berkeley (UC Berkeley)

• Novel Four Dimensional MR Spectroscopic Imaging Techniques For Human Tissues

  Organization: University of California, Los Angeles (UCLA)

  UCLA researchers have developed a novel four-dimensional (4D) MR spectroscopic imaging sequence combining two spectral with two spatial dimensions on a whole body MRI scanner in order to evaluate metabolites and saturated/unsaturated lipid groups non-invasively in human tissues. This technique will allow for better dispersion of several metabolite peaks and improved spectral assignment. These MRSI sequences are expected to improve the overall specificity in cancer diagnosis.

• Novel Macromolecular Contrast Agents For Medical Imaging

  Organization: University of California, San Francisco (UCSF)

  UCSF investigators have developed several new class of MMCMs, including agents that closely mimic the natural shape of biomacromolecules (such as the substantially-tested albumin molecule) and that utilize polyethyleneglycol (PEG) derived dendrimers as the molecular backbone.  These innovative MMCMs have a number of advantages over current clinical standards as well as previously designed MMCMs, including better biocompatibility, biodegradability, complete body clearance and non-immunogenicity.

• Novel Method for Non-Invasive Radiological Image Generation Without Blood Sampling or Metabolite Processing

  Organization: University of California, San Francisco (UCSF)

  Investigators at the UCSF Radiology and Biomedical Imaging Department have developed a novel non-invasive method (Patlak-P) to generate parametric maps for clinical visualization that is based on the currently used Patlak Ki (Patlak) method. Importantly, Patlak-P does not require determination of arterial input function or metabolite correction. This method and the associated algorithm can be implemented with any system used for dynamic radionuclide imaging.   The investigators have validated this method with oropharyngeal carcinoma ...

• A Novel and Powerful Method for Signal Processing in Medical Imaging (MEG, MRI, etc.), and Other Scientific and Engineering Applications

  Organization: University of California, San Diego (UC San Diego)

  UCSD researchers have developed an effective and clinically practical multi-core beamformer (MCBF) method and its enhanced version (eMCBF) to address the various shortcomings of conventional signal reconstruction approaches including earlier dual-beamformer method, the coherent source suppression model (CSSM), and the nulling beamformer (NB). MCBF uses a new lead-field based inverse-modeling technique to simultaneously reconstruct highly-correlated and uncorrelated sources from noisy sensor array data by incorporating the lead-field vectors ...

• PORTABLE IMAGING DEVICE FOR TUBERCULOSIS DETECTION

  Organization: University of California, San Francisco (UCSF)

• Classification of Otitis Media Images

  Organization: University of Pittsburgh

• Biological Materials: 4T1-Luc and 66c14-Luc Cell Lines

  Organization: Tufts University

• A New Handheld Optical Molecular Imaging Platform for Wound Care and Other Applications

  Organization: University Health Network

  Researchers at the University Health Network have recently developed an innovative and handheld optical molecular imaging device that enables point-of-care analysis of acute and chronic wound infections using biophotonic technologies. Product Development: The hand-held imaging system leverages the unique capabilities of fluorescent imaging to provide clinicians with information about the bacteria present in awound. It is a completely non-invasive technology that acquires images in a manner similarto standard point-and-shoot digital cameras. ...

• Integrated Microfluidic Platform For Parallel Screening Of A Chemical Library

  Organization: University of California, Los Angeles (UCLA)

  A research group at UCLA has designed and fabricated a microfluidic chemical reaction circuit (CRC) that can perform multiple in situ click chemistry reactions in parallel. In situ click chemistry produces high-affinity inhibitors of target enzymes through the assembly of building block reagents irreversibly inside a target's binding pockets. Using the technique in conjunction with microchannels, investigators used the technology for the high-throughput screening of an in situ click chemistry library composed of 1,024 independent ...

• Image Quality Based Optimization of CAD Schemes

  Organization: University of Pittsburgh

• CT - X-Ray Imaging with an MRI System

  Organization: Stanford University

• Dual Gate Oxide Transistors for Downscaling CMOS Image Sensors

  Organization: Stanford University

• MRI - High Order Shimming Using Regularization Methods

  Organization: Stanford University

• Magnetic Resonance Spectroscopic Imaging Method to Monitor Progession and Treatment of Neurodegenerative Conditions

  Organization: Stanford University

• MRI - Magnetic Resonance Imaging Using Spiral FISP with Moment Compensation

  Organization: Stanford University

• MRI - Catalyzing the Transient Response

  Organization: Stanford University

• High Dynamic Range Image Formation and Motion De-blurring in CMOS Image Sensor

  Organization: Stanford University

• Enhancing CMOS Image Sensor Dynamic Range and SNR

  Organization: Stanford University

• MRI - Use of Oscillating Equilibrium SSFP for MR Angiography

  Organization: Stanford University

• MRI - New Methods Used in Diminishing Variance Algorithm

  Organization: Stanford University

• MRI - Variable-Density One-Shot Fourier Velocity Encoding MR Imaging

  Organization: Stanford University

• Medical CAD: Method for Reducing False Positives in Medical Imaging

  Organization: Stanford University

• CT - Volumetric CT

  Organization: Stanford University

• MRI - Dedicated Shim Coils for the Correction of Local MR Field Inhomogeneity

  Organization: Stanford University

• Integrated Color Pixel (ICP)

  Organization: Stanford University

• Reduction of Bulkwave Generation in CMUTS

  Organization: Stanford University

• Capacitive micromachined ultrasonic transducer (CMUT) with varying thickness membranes

  Organization: Stanford University

• CT - Maintaining the alignment of electric and magnetic fields in an x-ray tube operated in a magnetic field

  Organization: Stanford University

• Electrical Through-Wafer Interconnects

  Organization: Stanford University

• Medical CAD/Colonography: Identifying Similar Anatomical Features from Separate Imaging Datasets (Registration of Centerline Paths in Medical Imaging Data)

  Organization: Stanford University

• Medical CAD / Colonagraphy: Automated Differentiation Between Pre-Cancerous Colonic Polyps and Normal Tissue

  Organization: Stanford University

• Medical CAD: An Efficient Colonic Polyp Detection Solution Employing a 3D Free-Form Shape Recognition Approach

  Organization: Stanford University

• CT - A Method for larger Field of View in CT

  Organization: Stanford University

• MRI - Method for Image Reconstruction in Data Sharing Fourier Imaging

  Organization: Stanford University

• MRI - Rapid Measurement of Blood Flow

  Organization: Stanford University

• CT - Improved Sampling in Volumetric CT

  Organization: Stanford University

• Fabrication of CMUTs with Wafer-bond Technology

  Organization: Stanford University

• MRI - Method for MRI Velocity Measurements and 4D Flow software

  Organization: Stanford University

• Tubular Nitinol Mechanisms for an Ultrasound Imaging System of Intravascular Intervention

  Organization: Stanford University

• MRI - "IDEAL" MRI: Multipoint Chemical Shift Decomposition for MRI

  Organization: Stanford University

• A New Regime for Operating Capacitive Micromachined Ultrasonic Transducers

  Organization: Stanford University

• Medical CAD: Automated 3D Characterization of Lesions and Other Biological Structures (derived from a combination different methods including 3D transient thermal profiling)

  Organization: Stanford University

• Medical CAD / Vascular: Quantifying the Infrarenal Aorta and Iliac Arteries

  Organization: Stanford University

• Medical CAD / Vascular: Automated Measurement of Diameters and Volumes of Abdominal Aortic Aneurysms

  Organization: Stanford University

• Medical CAD / Vascular: Intelligent Vascular Separation and Visualisation Algorithm (Curved Slab Maxium Intensity Projections or CS-MIP)

  Organization: Stanford University

• Medical CAD / Vascular: Automated Quantification of Arterial Calcification in CT Studies

  Organization: Stanford University

• Two Beam Fluorescence Microscope

  Organization: Stanford University

• Adaptive Pixel for High Speed, Dynamic Range Imaging

  Organization: Stanford University

• Optimization of Image Sensor Pixels

  Organization: Stanford University

• Addressing CMUT Arrays

  Organization: Stanford University

• High Speed Videography

  Organization: Stanford University

• Medical CAD: Selective Fold Removal in CT Colonography using Physically-Based Simulation

  Organization: Stanford University

• "IDEAL" MRI: Homodyne Reconstruction with Dixon Fat-Water Separation

  Organization: Stanford University

• Matrix Lens System

  Organization: Stanford University

• Medical CAD: Automatic Lung Cancer Diagnostic Software (Monitoring Lung Nodule Growth over a Period of Time)

  Organization: Stanford University

• MRI - MRI: Generalized Image Reconstruction

  Organization: Stanford University

• Propagating Modes in Subwavelength Cylindrical Holes in an Optically Thick Metallic Film

  Organization: Stanford University

• Nonlinear Optical Endoscopy and Microscopy

  Organization: Stanford University

• Capillary for Optical Imaging

  Organization: Stanford University

• MRI - MRI: A Major Speed Increase for Banding Artifact Elimination in SSFP-MRI Utilizing the Super Field of View (sFOV) Technique

  Organization: Stanford University

• Scatter Correction Algorithm for X-ray and Volumetric CT

  Organization: Stanford University

• Serial Planar Immunofluorescence (SPI) Microscopy

  Organization: Stanford University

• MRI - Steady-State Free-Precession MRI with Significantly Increased Signal Bandwidth

  Organization: Stanford University

• Method to measure image density of digitized photographs for X-ray analysis

  Organization: Stanford University

• Anatomy-Based Radiograph Labeling and Retrieval

  Organization: Stanford University

• Accelerated tomographic image reconstruction algorithms on Graphics Processing Units (GPU)

  Organization: Stanford University

• MRI - An Apparatus To Perform Motion Corrected Magnetic Resonance Imaging

  Organization: Stanford University

• MRI - "IDEAL" MRI: Self-Calibration Methods for Parallel Imaging and Multi-Point Water-Fat Separation Methods

  Organization: Stanford University

• Tomographic Reconstruction for X-Ray Cone-Beam Scan Data

  Organization: Stanford University

• MRI - "IDEAL" MRI: Calibration Maps for Parallel Imaging Free of Chemical Shift Artifact

  Organization: Stanford University

• MRI - "IDEAL" MRI: Weighted Least-squares Water-Fat Separation

  Organization: Stanford University

• MRI - "IDEAL" MRI: Regularized Water-Fat Separation

  Organization: Stanford University

• MRI - "IDEAL" MRI: Sliding Window Reconstruction and Phase/Field Map Updating for Chemical Shift Imaging

  Organization: Stanford University

• "IDEAL" MRI: Methods for Combining Separate Water and Fat Images and Quantifying Fat

  Organization: Stanford University

• MRI - "IDEAL" MRI: Simultaneous T2* Measurement and Correction in Chemical Shift Imaging

  Organization: Stanford University

• Moving Table MRI with Frequency-Encoding in the Z-Direction

  Organization: Stanford University

• MRI - Fast Metabolic Imaging of Systems with Sparse Spectra

  Organization: Stanford University

• Medical CAD: Global Optimization Using Learning Enhanced Simulated Annealing (LESA); for lung CAD

  Organization: Stanford University

• Acoustic Cross Talk Reduction Method

  Organization: Stanford University

• 3-D Adaptive Filtering of Projection Data for Noise Reduction in Low-dose C-arm

  Organization: Stanford University

• Trench Isolated CMUT Arrays

  Organization: Stanford University

• MRI - Multi-resolution robust field map estimation for water and fat separation

  Organization: Stanford University

• MRI - Inverted Double Half RF Pulse for Ultrashort T2 Imaging

  Organization: Stanford University

• Rotational Stereo Roadmapping for navigating interventional radiology instrument

  Organization: Stanford University

• Multifunctional metal-graphite nanocrystals

  Organization: Stanford University

• A Method for Parallel Imaging with Calibration to a Separate Coil

  Organization: Stanford University

• A Method for Magnetic Resonance Image Reconstruction using Correlation Values

  Organization: Stanford University

• A Method for Magnetic Resonance Image Reconstruction with Parallel Imaging and Motion Correction

  Organization: Stanford University

• Array Tomography

  Organization: Stanford University

• MRI - 3D Cones Gradient Waveform Generation Software

  Organization: Stanford University

• CT - Raw Data Normalization in Inverse Geometry CT

  Organization: Stanford University

• MRI - Water and Fat Separation with Bipolar Multi-Echo Sequences

  Organization: Stanford University

• MRI - An auto-calibrating parallel imaging reconstruction method from arbitrary k-space sampling

  Organization: Stanford University

• MRI - A Fast Method for Designing Time-Optimal Gradient Waveforms for Arbitrary k-Space Trajectories

  Organization: Stanford University

• MRI - Slice-selective Tunable AdiaBatic Low peak Power Excitation (STABLE) pulse

  Organization: Stanford University

• Highly Fluorescent Magnetic Nanoprobes

  Organization: Stanford University

• Laser-driven deflection structure for charged particle beams

  Organization: Stanford University

• MRI - Motion Corrected Diffusion Tensor MRI

  Organization: Stanford University

• Method and Apparatus for Identification of Fluorescence

  Organization: Stanford University

• Fabrication of CMUTs

  Organization: Stanford University

• Robust Motion Correction Algorithm for Functional Magnetic Resonance Imaging

  Organization: Stanford University

• MRI - Multiple Repetition Time Steady-State Free Precession Imaging

  Organization: Stanford University

• A novel scheme of cone-beam CT imaging in radiation therapy

  Organization: Stanford University

• iPad: An Annotation Tool for Radiology Images

  Organization: Stanford University

• A noninvasive in vivo assay of inflammation and infection using hyperpolarized 13C magnetic resonance imaging.

  Organization: Stanford University

• Monolithic Integrated CMUTs Fabricated by Low-Temperature Wafer Bonding

  Organization: Stanford University

• Synchronous Method for Registering Anatomic Mapping Data to Models of the Anatomy

  Organization: Stanford University

• Directly Fabricated Nanoparticles for Raman Scattering

  Organization: Stanford University

• Micromachined Ultrasonic Transducer Having Compliant Post Structure

  Organization: Stanford University

• MRI - Method for Optical Pose Detection

  Organization: Stanford University

• Shift-Varying Line Projection using Graphics Hardware

  Organization: Stanford University

• Devices and Methods for X-ray Molecular Imaging Enabled by Biocompatable Nanophospher Imaging Agents

  Organization: Stanford University

• MRI - Contrast and Resolution Enhancement for Magnetization-Prepared MRI with Signal Compensation

  Organization: Stanford University

• Brain Tissue Quantification and Segmentation Using MRI

  Organization: Stanford University

• Medical Screening and Diagnostics Based on Air-Coupled Photoacoustics

  Organization: Stanford University

• Improved CT Imaging Through Simultaneous Acquisition of Scatter and Image Projection Data

  Organization: Stanford University

• Multimodal DAC Microendoscope Platforms

  Organization: Stanford University

• Algorithm to Reduce Artifacts in 4D Computed Tomography

  Organization: Stanford University

• Learning of Image Processing Pipeline for Digital Imaging Devices

  Organization: Stanford University

• FLOWANALYTIX: An Integrated Visualization and Quantitative Analysis Platform for Volumetric Phase-Contrast MRI

  Organization: Stanford University

• Behavioral Biomarker and Training Method for Diagnosis and Treatment of Anxiety & Depression

  Organization: Stanford University

• Planar Near Field Optical & Force Microscope

  Organization: Stanford University

• CMOS Area Image Sensor with Pixel Level A/D Conversion

  Organization: Stanford University

• MRI - Spiral Projection-Reconstruction Hybrid K-Space Trajectory

  Organization: Stanford University

• MRI: Method for Correcting Field Inhomogeneity Distortion in MRI

  Organization: Stanford University

• Method for improved temporal resolution in MR fluoroscopy

  Organization: Stanford University

• Novel fluorescent probe Cy7-APC

  Organization: Stanford University

• High-speed Inter-modality Image Registration via Iterative Feature Matching

  Organization: Stanford University

• Medical CAD: Method for Separating Objects from Background in Digital Images

  Organization: Stanford University

• Serial Analog-to-Digital Converter Using Successive Comparisons

  Organization: Stanford University

• Microfabrication of Sealed Membranes and their Applications

  Organization: Stanford University

• MRI - A Method for MR system eddy-current measurement

  Organization: Stanford University

• Improved Microfabrication of Acoustic Transducers

  Organization: Stanford University

• MRI - Phase Compensating RF Pulses for Magnetic Resonance Imaging and Spectroscopy

  Organization: Stanford University

• Converting a Low Dynamic Range Analog Signal to Large Dynamic Range Digital Floating Point Representation

  Organization: Stanford University

• MRI - Spatiotemporal Finite Element Method for Motion Analysis with Velocity Data

  Organization: Stanford University

• MRI - Removal of Interventional MR Device Distortion

  Organization: Stanford University

• Simultaneous Multi-Channel bit Serial Multiplication and Quantization

  Organization: Stanford University

• MRI - Non-Invasive Measurement of Frozen Tissue Temperature using MRI

  Organization: Stanford University

• MRI - Temporally Resolved, Three-dimensional MR Volume Acquisitions

  Organization: Stanford University

• Heavy Atom Labeling for High Resolution Structure Determination by Electron Microscopy

  Organization: Stanford University

• Minimum cost solenoid magnet and method of making same

  Organization: Stanford University

• MRI - Homogeneous Electromagnet for Prepolarized MRI

  Organization: Stanford University

• MRI - A Bipolar Magnet Configuration

  Organization: Stanford University

• MRI - More Efficient Data Encoding in Dynamic Magnetic Resonance Imaging

  Organization: Stanford University

• Medical CAD: Osteoporosis Screening Breakthrough using QCT (Quantitative CT) on Conventional Clinical Scanners

  Organization: Stanford University

• MRI - Phase-sensitive Method of Radio-Frequency Field Mapping for Magnetic Resonance Imaging

  Organization: Stanford University

• MRI - A Reduced Field-of View Method to Increase Temporal Resolution or Reduce Scan Time in CINE Magnetic Resonance Imaging

  Organization: Stanford University

• MRI - Linear Combination Steady-State Free Precision MRI

  Organization: Stanford University

• Through Wafer via Connections

  Organization: Stanford University

• Cross Talk Reduction in cMUTs

  Organization: Stanford University

• CMOS Image Sensor with Self Reset Pixel Architecture

  Organization: Stanford University

• MRI - Magnetic Resonance Imaging Using Off-Centered Spiral Trajectories

  Organization: Stanford University

• MRI: Transmission Line Techiques for MRI Catheter Coil Miniaturization and Tuning

  Organization: Stanford University

• Integrated Array of Image Sensors

  Organization: Stanford University

• CMOS Video Sensor System with Improved SNR Under Low Illumination

  Organization: Stanford University

• Method for Adaptive Spectral Sensing

  Organization: Stanford University

• MRI - Real-time Gridding Reconstruction Server

  Organization: Stanford University

• MRI - Real-time Interactive Pulse Sequence

  Organization: Stanford University

• Compact transform spectrometer based on sampling a standing wave

  Organization: Stanford University

• Learning of Image Processing Pipeline for Digital Imaging Devices

  Organization: Stanford University

• FLOWANALYTIX: An Integrated Visualization and Quantitative Analysis Platform for Volumetric Phase-Contrast MRI

  Organization: Stanford University

• Benzofurazan Disulfide Derivatives as Fluorogenic Agents

  Organization: South Dakota State University

  This technology provides benzofurazan compounds, including benzofurazans that are fluorogenic agents, benzofurazans that are fluorescent agents, and benzofurazan thiol conjugates. The benzofurazans can be, for example, benzofurazan thioethers. The benzofurazans can be benzofurazan sulfide compounds that are "thiol-specific" fluorogenic agents. This invention describes the design, synthesis and determination of specificity, sensitivity and stability of novel thiol-specific Benzofurazan fluorogenic and fluorescent agents.

• Lanthanide Complexes for Biomedical Imaging

  Organization: South Dakota State University

  In chemical and bioassay applications the lanthanide complexes can be employed as luminescent probes. SDSU has produced a lanthanide ion complex coordinated by one or more organic liquids and methods for using the lanthanide complexes in lanthanide-based binding assays. The lanthanide complexes are characterized by excitation wavelengths in the visible region of the electromagnetic spectrum, emission wavelengths in the near infrared (NIR) and/or visible regions of the electromagnetic spectrum, high fluorescence quantum yields and long ...

• Wireless Heart Beat and Respiration Detector

  Organization: University of Florida

• MR Imaging of Bone and Musculoskeletal Tissues Via Multi-Component Analysis

  Organization: University of California, San Diego (UC San Diego)

  UC inventors have developed proprietary algorithms, methods, and software that could give clinicians a non-invasive, quantitative tool for the direct measurement of the health of bones and joints. Specifically, ultrashort TE (UTE) imaging has been used to directly assess the structural and biochemical composition of bone and joint tissues. This approach, which is not limited to specific types of bone or to articular cartilage, allows a real-time, direct assessment of the process and extent of and/or joint degeneration from early manifestation ...

• Intermolecular Multiple-Quantum Coherence MR Imaging in Humans

  Organization: Indiana Univ-Purdue University Indianapolis

  The present invention is an MRI imaging method based on MQC (multiple quantum coherence), and in particular on DQC (double quantum coherence) for soft tissue imaging in humans. The present invention permits DQC MR images in human brains. This was achieved by using a source of signals that had previously been considered as non-existent or too difficult to be detected. Acquisition of the human brain images based on DQC in water was successful for the first time on a 1.5T clinical scanner. The DQC signal provides new contrast for the detection ...

• A Method and Apparatus for Alignment of a Sequence of High Dimensional Data

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 3043BackgroundImage registration transforms different sets of data into a single coordinate system and is thus critical for comparison and integration of data obtained from different measurements. This technique is useful in the medical imaging field as well as in other monitoring, observation and tracking applications. Image registration is complex especially when the images to be correlated exhibit intensity differences and spatial variations. One of the main issues arises when intensity differences are due to the sensor itself ...

• Compact X-ray Source

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 2758BackgroundIn order to satisfy the needs of basic research as well as industry, there is currently great interest in coherent, ultrashort-pulse-duration and high-power light sources. In basic research, large (kilometer) x-ray synchrotrons have met some of these needs, but they are extremely expensive, costing hundreds of millions of dollars. Thus, there is a need for an affordable and compact source, having a small enough footprint to fit in a university or industrial research laboratory or factory setting. Additionally, light ...

• Acoustically Induced Blood Stasis and in vivo Optical Spectroscopy Thereof

  Organization: Indiana Univ-Purdue University Indianapolis

  The present invention combines the effects of ultrasound induced blood stasis and optical spectroscopy to create a new, non-invasive tissue imaging and diagnostic tool. It has applications in non invasive tissue diagnosis, localized drug delivery, non-invasive manipulation of vascular blood flow and oxygenation for generally enhanced therapeutic and diagnostic effects. Presently there are few tissue diagnosis methods approved for clinical use. For some tissue diagnosis purposes, imaging molecules is sufficient (e.g. MRI, CT, PET etc.). ...

• Three-Dimensional Orthogonal Phased Array (3DOPA) Receiver Coil for MR Imaging

  Organization: Indiana Univ-Purdue University Indianapolis

  This invention relates to hardware coil design for MRI scanner systems. Specifically, this is a phased array coil with orthogonal coil elements designed to improve SNR and enhance parallel imaging capabilities. This phased array MRI coil design has immediate applications in high resolution primate brain imaging for modeling studies of brain disease, development and function. For future applicatons, the design may be adapted to human head coils in vertical field systems and human breast coils in horizontal field systems providing ...

• Method for Statistical Reconstruction of X-Ray Computed Tomography Images from Multiple Scans with Energy Diversity

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 2228BackgroundTomographic images of the spatial distribution of attenuation coefficients in the human body are valuable for medical diagnosis. Most hospitals have CT scanners for producing such images. Attenuation images are also useful in a variety of scientific studies, in industry for non-destructive evaluation, and for security purposes like baggage inspection. X-ray CT scanners are also being integrated into SPECT and PET scanners to provide accurate attenuation correction for emission image reconstruction and for precise ...

• Acoustic Tweezers

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 2289BackgroundOptical tweezers have been successfully used to manipulate both subcellular structures and individual biological macromolecules. While optical tweezers are widely used in research, they are restricted to isolated preparations because they require an optically refractive bead.Technology DescriptionResearchers at the University of Michigan have developed a method and system to create and acoustically manipulate structures such as cells and subcellular structures at a nanoscopic scale without the requirement of an ...

• An Imaging System Using Combined Mechanical and Electronic Collimation

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 2334BackgroundImage of the radiation density of a source of photons located in an object in real-time may be used in various medical imaging techniques. In this regard, various collimation methods for nuclear medicine applications have been explored, including mechanical collimators involving certain degrees of multiplexing. Unfortunately, this improvement is usually achieved at the expense of the amount of information conveyed by each detected photon. As a result, the signal-to-noise ratio in the collected data deteriorates ...

• Targeted Nanoparticles for Laser Induced Breakdown

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 2393BackgroundMuch effort has been devoted to research on laser-induced breakdown (LIB) since the advent of powerful lasers, because of the importance of LIB in diverse fields including laser surgery and micromachining. So far, much less attention has been paid to altering the breakdown threshold of the materials themselves and achieving a controllable breakdown by modifying the material. LIB in well-designed materials has a wide range of potential applications.Technology DescriptionUniversity of Michigan researchers have ...

• Noise-adapting Edge-preserving Regularization for X-ray Reconstruction

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 2907BackgroundImage reconstruction involves recovering an unknown function f(r) from the acquired scan data, where r denotes spatial position in 2D or 3D coordinates. Typically, a discretized version of f(r) is reconstructed. Often f(r) is represented using a finite-series expansion as follows: f .function. ( r ) = j = 1 M .times. x j .times. b j .function. ( r ) , ( 2 ) where b.sub.j(r) denotes spatial basis functions and each x.sub.j denotes an unknown coefficient. Therefore, determining f(r) simplifies to determining the ...

• Technique for Guidance and Monitoring of Photodynamic Therapy with Photoacoustic Technology

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 3593BackgroundPhotodynamic therapy (PDT) represents a relatively new approach to the treatment of various cancers and nonmalignant, hyper-proliferative diseases. Approved by the FDA, PDT is presently being used for esophageal cancer and early stage lung cancer. It is also being utilized as an investigational therapy for obstructive lung cancer, Barrett's esophagus, head and neck, and prostate cancer. PDT is particularly suited to use in head and neck cancers and prostate cancer because of its ability to minimize damage to nerves and ...

• Photoacoustic Indicators

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 3693BackgroundMeasurement of fluorophore lifetimes provides a sensitive probe of the microenvironment of the fluorophore, with various applications in biology and medicine. Its sensitivity is not affected by the concentration of the fluorophore or by the excitation light intensity. This is particularly significant in biological and clinical applications where dye concentration cannot be precisely controlled and light fluence is highly non-uniform. Optical imaging techniques have been developed to map the distribution of ...

• Conducting Phase-Sensitive Acoustoelectric Hydrophone

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 3677BackgroundConventional methods for mapping cardiac currents fields lack either spatial resolution (e.g., ECG) or are time consuming (e.g, intra-cardiac catheter electrode mapping).Technology DescriptionResearchers at the University of Michigan have developed a new method and apparatus that measures an ultrasound transducer's beam pattern and calibrated focal pressure based on the interaction between pressure and current. This invention improves on existing technology to calibrate an ultrasound transducer and measure/image its 2D ...

• Motion Artifact Reduction in Iterative Reconstruction for X-ray Imaging

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 3967BackgroundIterative reconstruction methods have shown benefits for improving image quality in a variety of tomographic imaging modalities including X-ray CT. However, most iterative methods are based on models that assume the object is static (motionless) during the scan. Object motion during the scan leads to measured data that is inconsistent with the models and that can cause artifacts in reconstructed images. In the clinical environment, it is common to encounter patient cases with motion that is difficult to suppress or ...

• Hybrid Optimization for X-ray Iterative Reconstruction

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 3966BackgroundA computed tomography (CT) imaging system typically includes an x-ray source that projects fan- or cone-shaped x-ray beams through an object being imaged, such as a patient, to an array of radiation detectors. To reduce the total scan time required for multiple slices, a "helical" scan, which allow for large volumes of the object to be scanned at a quicker rate using one or more photon sources, are used. This technique generates a single helix from a fan beam helical scan, which, when mapped out by the fan beam, ...

• Real-Time, Multi-Channel, Multi-Site Analysis of Cardiac Electrograms in the Time and Frequency Domains

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 3958BackgroundCardiac electrograms are used to evaluate electrical activity of the heart, which may also be used clinically for cardiac mapping to study arrhythmias and basic electrophysiology of the heart. Current practice is primarily based on subjective visual assessment of complex electrograms which lack specificity and may have direct effects on efficacy, safety and efficiency of the procedure.Technology DescriptionUniversity of Michigan researchers developed software and hardware for the acquisition and analysis of cardiac ...

• A Distribution of Type I Collagen Morphologies in Bone

  Organization: Indiana Univ-Purdue University Indianapolis

  UM File # 4410BackgroundAlthough many diseases affect bone through changes in mineral and the organic matrix, osteoporosis is the most common bone disease and is a major medical and economic burden facing our society. Each year, an estimated 1.5 million Americans suffer an osteoporotic fracture resulting in direct-care expenditures of 18 billion dollars a year and often leading to a downward spiral in quality of life or even death. Current diagnostic methods for osteoporosis focus exclusively on bone quantity and mineral content, ...

• Diagnostic and Therapeutic Particles with Decreased Cavitation Threshold: Payload Released by Focused Ultrasound

  Organization: Indiana Univ-Purdue University Indianapolis

  Inventors at UC San Diego have recently developed compositions of matter, methods of use, and methods of manufacturing vehicles that can be triggered like a microbubble but with the stability of a traditional liposome. This allows them to take advantage of the years of liposome technology with the added benefit of ultrasound triggering. By packaging an acoustically sensitive nanoparticle with specific lipids, the therapeutic payload is stabilized until application of focused ultrasound, which releases the payload only in tissues of ...

• Recombinant Luciferase Gene, Luciferase Fusion Proteins, and Methods of Use

  Organization: Indiana Univ-Purdue University Indianapolis

  Researchers at UC San Diego have been awarded three U.S. patents for the production of recombinant Coleoptera luciferase (U.S. patent number 5,583,024), their hybrid proteins (U.S. patent number 5,674,713), mutated proteins (U.S. patent number 5,700,673), and their uses as reporter molecules. The patent claims cover compostitions and methods to produce recombinant Coleoptera luciferase and hybrid proteins from either RNA or DNA templates. The recombinant luciferase can be expressed in procaryotic or eucaryotic cells, lysates of those cells, ...

• Acoustic Daylight Imaging

  Organization: Indiana Univ-Purdue University Indianapolis

  A new acoustic technique for providing real-time visual images of the interior of the ocean has been invented by a researcher at Scripps Institution for Oceanography. The imaging process relies on ambient noise, or "acoustic daylight," as the source of illumination with the underlying idea being analogous to photography in the atmosphere with daylight illuminating the subject. An object in the noise field scatters the incident sound and the scattered field is focused with an acoustic lens to form an image on an array of transducers. After ...

• A MRI Arterial Spin Labeling Software for Quantification of Regional and Complete Pulmonary Blood Flow

  Organization: Indiana Univ-Purdue University Indianapolis

  UC San Diego researchers have developed a reliable MRI ASL pulse-sequence software to measure the PBF, with the entire imaging sequence being completed in one single breath-hold. It is based on the algorithm described in the published paper by Bolar et. al. (referenced below). Regional PBF can be quantified using an ASL-FAIRER (flow-sensitive alternating inversion recovery with an extra RF pulse) technique coupled with the single-subtraction approach of using one tag-control pair acquisition at an inversion time (TI) matched to the ...

• Fluorescent Amyloid Binding Agents for Diagnosis of Alzheimer’s Disease

  Organization: Indiana Univ-Purdue University Indianapolis

  A common structural feature of known amyloid-binding agents is an electronically-polarized, extended aromatic system that is inherent to a family of fluorescent probes known as molecular rotors. Features of molecular rotors, which inherently decrease the non-radiative decay rate and increase fluorescence emission upon binding to aggregated beta-amyloids, were incorporated into a general design of novel, amyloid-binding agents.

• Application of Structured Illumination for in vivo Human Retinal Imaging

  Organization: Indiana Univ-Purdue University Indianapolis

  In structured illumination microscopy, an object is illuminated by sinusoidally patterned light, rather than conventional uniform illumination, and digital image processing is done to obtain axial sectioning (3D imaging) and super-resolution (imaging at frequencies beyond the normal diffraction cutoff of the optical system). The technique can be used in microscopes for imaging both fluorescent and non-fluorescent objects, such as tissues, cells and micro-structures such as semiconductor chips, in both in vitro and in vivo applications. A key ...

• High Affinity Binding Proteins to Integrins

  Organization: Indiana Univ-Purdue University Indianapolis

  This technology is related to the development of high affinity binding proteins to specific integrin proteins highly associated with cancer metastasis. Applications of these targeting molecules include tumor imaging, targeted tumor therapy, and targeted gene delivery. These molecules are more stable, easier to make, and more amenable to protein engineering techniques than short peptides and antibodies.

• MRI Imaging Based on Quantitative Ultrashort Echo Time Imaging of Short T2 Tissues

  Organization: Indiana Univ-Purdue University Indianapolis

  This method uses quantitative imaging techniques to measure magnetic resonance relaxation time. Specifically, the invention combines 2D and 3D, ultrashort, echo time (TE) sequences with appropriate pulses and can be further combined with efficient long T2 suppression pulses to increase the short T2 contrast and reduce long T2 contamination in T2, T2*, T1ρ, and T1 quantification.

• MR Imaging of Bone and Musculoskeletal Tissues Via Multi-Component Analysis

  Organization: Indiana Univ-Purdue University Indianapolis

  UC inventors have developed proprietary algorithms, methods, and software that could give clinicians a non-invasive, quantitative tool for the direct measurement of the health of bones and joints. Specifically, ultrashort TE (UTE) imaging has been used to directly assess the structural and biochemical composition of bone and joint tissues. This approach, which is not limited to specific types of bone or to articular cartilage, allows a real-time, direct assessment of the process and extent of and/or joint degeneration from early manifestation ...

• Non-Invasive, Sensitive Diagnostic for Viral Myocarditis

  Organization: Indiana Univ-Purdue University Indianapolis

  Researchers from UC San Diego have identified altered forms of a protein complex present in cardiac muscle (the dystrophin-glyoprotein complex), which is associated with dilated cardiomyopathy caused by enteroviruses. Specifically, the presence of a unique, enteroviral protease 2A-cleavage product provides a highly specific and sensitive biomarker for enteroviral-mediated cleavage of dystrophin.

• High Resolution, Diagnostic Imaging of Fat Composition and Regional Location

  Organization: Indiana Univ-Purdue University Indianapolis

  Commonly employed MRI techniques for separating water and fat exploit differences in the precession frequency of protons in fat and water. UC researchers have simplified and improved analysis and data processing by identifying three most-relevant parameters that can be used to qualitatively and quantitatively image fat. By reducing the complexity of an MRI-generated fat spectrum, one is able to significantly improve the diagnostic utility of a scan with minimal effect on the scan time.

• A Novel Method to Increase the Perfusion Signal to Noise Ratio (SNR) in Velocity Selective Arterial Spin Labeling for MRI

  Organization: Indiana Univ-Purdue University Indianapolis

  UC San Diego researchers have developed a VSASL method to address the first property. In conventional VSASL, the tagging of arterial blood is applied once before imaging and the tagged blood undergoes uniform T1 decay prior to image acquisition. If two or more VSS modules are used, some of the recovered tagged blood will be saturated again at a later time. Multiple VSS modules produces tagging that more closely approximates the ideal situation of being continuous. The tagged blood is therefore closer to saturation at the time of ...

• Efficient Method of Mapping Sources of Abnormal Routes of Vascular Circulation Regardless of Their Location Using MRI

  Organization: Indiana Univ-Purdue University Indianapolis

  UC San Diego researchers have developed an efficient method for estimating both the location and resonance offset of all feeding arteries of VEASL from randomly encoded data, allowing for identification of source vessels without prior knowledge of their locations. The method uses unipolar rather than bipolar vessel encoding gradient lobes providing the same encoding functionality, which results in nearly complete insensitivity to resonance offsets at the tagging plane.

• Real-Time Position Monitoring and Adaptive Head Motion Control Method for Frameless Stereotactic Radiosurgery/Radiotherapy

  Organization: Indiana Univ-Purdue University Indianapolis

  The system measures real-time 6D optical position feedback for gating the treatment beam and guiding a motor controlled head motion compensation stage. It consists of a central control computer, an optical patient motion tracking system, and a motion compensation stage. The infrared tracking system is used to monitor four optical reflective markers with an accuracy of -0.25 mm. Measurements are calculated on six degrees of freedom (xyz + rotations). A styrofoam head cast is custom-built for patient support and attached to a linear ...

• CT, PET, MRI, EPRI Image Reconstruction Algorithm for Medical and Security Imaging

  Organization: Indiana Univ-Purdue University Indianapolis

  CT, PET, MRI, EPRI, and other imaging techniques rely on iterative or analytic image reconstruction algorithms to convert raw scan data into a 2D or 3D image. To reduce scanning and computational time, thereby enabling real-time targeted imaging, Prof. Xiaochuan Pan and his laboratory have developed an analytic chord-based BPF algorithm that requires only a minimum dataset to exactly reconstruct a region of interest. The algorithms are compatible with a variety of source trajectory scan geometries and can minimize motion contamination in an ...

• Image Processing Methods for Computing the Volume of Tumors and Nodules from 3D Medical Images

  Organization: Indiana Univ-Purdue University Indianapolis

  The algorithmic methods in the present invention have application in the sizing of tumor candidates, especially for gauging the growth over time of suspect nodules for diagnosis of malignancy of disease. This method provides more accurate automatic determination of tumor size and suspicious nodules. Recent advances in stereotactic radiation therapy has enabled treatment of small lesions with high (>90%) success rates. Several lung tumor screening studies have shown more than 13% of subjects present with suspicious nodules, but that upon ...

• Non-Invasive in-vivo Imaging of Mechanoreceptors in Human Skin Using Confocal Microscopy

  Organization: Indiana Univ-Purdue University Indianapolis

  This invention relates to a technique for non-invasive in vivo imaging of the sensory nerve endings in the skin or Meissner's corpuscles using confocal microscopy. Assessment of sensory nerve endings in the skin (Meissner's corpuscles) by means of invasive punch skin biopsy from the palmar surface of the hand or fingers or the sole of the feet has been done for a century as a research technique to understand sensory function and has been considered a potentially useful approach to study and diagnose sensory loss and sensory neuropathies in ...

• Compounds for use in cocaine abuse with reduced opoid side effects

  Organization: Indiana Univ-Purdue University Indianapolis

  The invention is based on the discovery that nonselective ? agonists that possess receptor-mediated effects in addition to their ? agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can highly selective ? agonists. The invention includes a number of new compounds having both nonselective ? opioid receptor agonist activity and additional activity at opioid receptors. These compounds are useful for the treatment of cocaine abuse, and can also be radiolabeled for use as ...

• Improving Vision and the Resolution of Retinal Images by Measuring and Correcting the Wave Aberration of the Eye

  Organization: Indiana Univ-Purdue University Indianapolis

  Wavefront measurement of all the aberrations in the human eye can make possible correction of vision which goes beyond conventional spectacles and contact lenses. This correction of higher order aberrations can be applied in custom laser refractive surgery, intraocular lenses and improved custom c contact lenses. In addition, the measurement and correction of aberrations improves the quality of retinal imaging, used to diagnose diseases in the back of the eye, in such instruments as scanning laser opthtalmoscopes and optical coherence ...

• Retinal Imaging of Low Light Signals

  Organization: Indiana Univ-Purdue University Indianapolis

  This technology enables high resolution in vivo images of the retina by a technique of simultaneous image capture and dual registration, which corrects for the natural movement of the living eye to enable many imaging frames to be combined to increase the signal to noise ratio from very weak signals, such as those from fluorescence or phase imaging, by monitoring the eye motion with conventional reflectance imaging. Retinal imaging is done to diagnose retinal disease, such as diabetic macular edema, retinitis pigmentosa, age-related macular ...

• Image Authentification and Data-Hiding

  Organization: Indiana Univ-Purdue University Indianapolis

  The technology is a technique for hiding data inside an image in a lossless, "reversible" manner such that the original signal can be recovered unchanged after the hidden information is extracted. The technique is valuable when it is critical both to authenticate an image (to identify it and assure that it has not been tampered with) and to convert that authenticated image to its original form with each pixel unchanged. The software technology, which we have called AuthentImage , embeds imperceptible tags (watermarks) into an image without ...

• Extended Depth of Field Imaging for Bar Code Readers

  Organization: Indiana Univ-Purdue University Indianapolis

  The technology combines a novel multi-focal aspherical lens with computer image processing to provide an imaging system with up to a ten-fold increase in the depth of field over conventional imaging. The technique can provide bar code readers with a dramatic depth of field improvement, a reduction in mechanical complexity and increase in exposure utilization. The invention uses a lens with a focal length that varies continuously with radius. For each distance, there is an annular portion of the lens, which will provide a sharp image. The ...

• Fiber Laser Super-Continuum Light Source

  Organization: Indiana Univ-Purdue University Indianapolis

  A novel tapered doped optical fiber structure, when coupled to an external laser, can produce broadband ultra-short

• Space-Variant Waveplates for Polarization Conversion

  Organization: Indiana Univ-Purdue University Indianapolis

  This technology is a waveplate which converts homogeneously polarized light into spatially inhomogeneously polarized light, such as a radially polarized beam converted from a linearly polarized source. Such inhomogeneously polarized light can abe used in dark field microscopy and in confocal microscopy to detect phase or gradient changes in materials, to enhance image contrast and edge resolution. The cylindrical vector beams can provide an alternative view in microscopy for resolving fine details and edges, as an alternative to linear ...

• Double-Focus Imaging System

  Organization: Indiana Univ-Purdue University Indianapolis

  This technology creates discrete, axially displaced focal regions in an optical system to provide a sharp focus at two separated planes. This could enable the simultaneous inspection of two faces of high quality glass plates, such as those used in liquid crystal displays. Another such use would be in the inspection of semiconductor masks and reticles, which often must be examined at two planes, for example at both the top and bottom of a trench. It could be used in a confocal imaging system to provide simultaneous acquisition of two separate ...

• Space-Charge-Free PN Junction

  Organization: Indiana Univ-Purdue University Indianapolis

  This concept can be used in semiconductor devices which suffer from thermal process which cause noise or leakage currents, such as infrared detectors, photodiodes, bipolar transistors and solar cells. The pn junction is a fundamental building block of semiconductor devices, such as diodes, transistors, optical sensors, diode lasers and LEDs. All earlier pn junctions have contained a space charge region (sometimes called the depletion layer) between the p-type and n-type layers of the device. Thermal processes in space charge regions case ...

• Image Authentification and Data Embedding

  Organization: Indiana Univ-Purdue University Indianapolis

  The software technology, which we have called AuthentImage , embeds imperceptible tags (watermarks) into an image without causing any loss of the image information. The tags embedded within the image provide a verification mechanism to assure that the image has not been altered. The information in the embedded tags can be extracted and is used to identify the image, establish its source, and verify its integrity (assure that it has not been tampered with). The ability to assure that authenticity of an image is useful in medical imaging, ...

• Ultra-Small Highly Fluorescent Near-IR Quantum Dots

  Organization: Indiana Univ-Purdue University Indianapolis

  This technology provides a process for synthesis of PbSe quantum dot clusters, which are highly fluorescent in the near infra red, of extremely small diameter (< 2 nm), and easily fabricated. In-vivo biological imaging in the near infrared, where there is reduced absorption of the light by biological fluids, down to the single molecule level, including deep tissue cancer imaging and intra-cellular diagnostics on a single protein or single copy level. These particular quantum dots have been found to have highly useful characteristics: ...

• Rapid, Automatic Measurement of the Eye&#039;s Wave Aberration

  Organization: Indiana Univ-Purdue University Indianapolis

  A process for computing the aberrations of the eye in real time from wavefront measurements using a wavefront sensor such as a Hartmann-Shack detector. Real-time determination of the aberrations of the living human eye is necessary for high resolution imaging of the retina for diagnostic evaluation. This is necessary because the eye is constantly moving. The aberrations of the eye can be determined at rates as high as 60 times a second. The algorithms can be run on a simple computer processor. Aberrations for different pupil sizes are ...

• Digital MEMs Amplitude and Phase Control of an Optical Wavefront

  Organization: Indiana Univ-Purdue University Indianapolis

  This concept enables the generation of an arbitrary optical wavefront for "active optics" and "adaptive optics" digitally. "Active optics" is used to change a wavefront on demand and hold it steady, for such applications optical metrology for lens inspection. "Adaptive optics" applies when correcting a rapidly changing distorted optical wavefront into a plane wave, or conversely converting a plane wave into an arbitrarily varying output wavefront. Adaptive optics is used today to correct for atmospheric turbulence in astronomical telescopes ...

• Modified Avidin -Biotin Technique

  Organization: Indiana Univ-Purdue University Indianapolis

  In indirect enzyme-linked immunohistochemical procedures, the secondary antibody serves the pivotal role of linking the primary antibody bound to the antigen of interest in a tissue section with a tertiary complex containing an enzyme reporter molecule. One of the most common methods for this is the avidin-biotin-complex (ABC) method. This method is simple, has high signal amplification, and low background noise. These features of the ABC method have prompted its widespread use as an immunohistochemical detection system. There is, ...

• Wavelets and the Fractal Structure of the ECG

  Organization: Indiana Univ-Purdue University Indianapolis

  The detection of ventricular tachycardia, a possibly fatal cardiac arrhythmia, is a critical medical issue. However, using current technologies, doctors can not accurately identify patients at risk for this deadly disease. In response to this critical problem, University of Pennsylvania researchers have developed a novel solution: wavelet analysis, a mathematical tool that decomposes non-linear signals. Researchers have been able to detect ventricular tachycardia using wavelet analysis on ECG signals, electrical activity measurement of ...

• Block Co-Polymer Worm Micelles for Drug Delivery and Imaging

  Organization: Indiana Univ-Purdue University Indianapolis

  For gene therapy, cancer treatment and other therapeutic applications, there is a need for drug/agent delivering carries that have a long circulation time (few days) in the body and are permeable to cell membranes. Current choices are viruses and/or lipos

• Externally Moveable Intracavity Probe for MRI Imaging and Spectroscopy

  Organization: Indiana Univ-Purdue University Indianapolis

  Insertable intracavity probe for use in enhanced magnetic resonance imaging of a body cavety, specifically the colon. The probe consists of an elongate shaft with a handle at its proximal end and an inflatable balloon structure at its distal end containing a loop-type pickup coil for connection to an interfacing network. When inserted in a body cavity, the balloon structure is positioned adjacent to an area of interest, and the inflation and deflation of the balloon allows for optimal positioning of coil near the area of interest.

• Intraoperative Beta-Probe

  Organization: Indiana Univ-Purdue University Indianapolis

  Although devices such as scintillators can be used to detect radiation, for example, beta-radiation-emitting tracers in tumors, they have met with limited success due to their sensitivity to background gamma radiation. Since most beta-emitting isotopes also have gamma emissions, a detector that is sensitive to gamma rays is likely to be affected by background gamma radiation and lead to ambiguity in the location of the tumor. Existing beta-sensitive probes are limited in the face of metastasis from a small tumor, and typically require ...

• Magnetic Resonance - Electrical Impedance Tomography

  Organization: Indiana Univ-Purdue University Indianapolis

  Measurements of the electrical properties of human tissues can provide anatomical images of the body and information about the pathological state of tissue. Electrical impedance tomography (EIT) and magnetic resonance current density imaging (MRCDI) are two techniques currently used to measure the electrical properties of human tissue. EIT produces images of the spatial distribution of impedance of a body by applying current to one set of electrodes and then measuring the voltage differences between adjacent sets of electrodes. However, ...

• Contrast-Enhanced US Methods for Measuring Low Blood Flow

  Organization: Indiana Univ-Purdue University Indianapolis

  Angiogenesis, or new vessel formation, occurs through tightly regulated processes under normal physiological situations. Under pathological conditions, such as inflammation and neoplastic formations, these tight controls are breached with ensuing uncontrolled angiogenesis from existing vasculature. With such conditions there is a need to measure blood flow through new and existing blood vessels. Although current methods of Doppler ultrasound measure blood flow through relatively larger vessels, they do not permit measurement of flow ...

• Scale-Based Image Filtering Methods Preserving Boundary Sharpness and Fine Structure

  Organization: Indiana Univ-Purdue University Indianapolis

  Current MRI protocols yield low signal to noise ratio (SNR) and low contrast-to noise ratio (CNR,) resulting in poor image acquisition. A number of initiatives have been established to address this problem. For example, post acquisition filtering is a major off-line image processing technique used to improve SNR and CNR. Unfortunately, post acquisition filtering often diffuses or blurs important structures. [An alternative is to use 2D or 3D imaging techniques which acquire images at a higher resolution. However, such methods increase the ...

• Event Information Display System

  Organization: Indiana Univ-Purdue University Indianapolis

  University of Pennsylvania faculty have devised a special event information display system, named the Marching Order, which takes input to classify an actor and displays and presents associated content. At a college graduation ceremony, for example, non-actors (administrators) and actors (graduates) would input information into the systemís database consisting of graduate and presentation (non-actor) information, using the administrative function of the application. The presentation aspect of the system would be utilized with an input ...

• A Nanometer-Sized Carrier for Diagnostic Imaging, Gene Therapy and Drug Delivery

  Organization: Indiana Univ-Purdue University Indianapolis

  Synthesis, functionalization and surface treatment of nanoparticles is an arfea of utmost importance in the field of medical nanotechnology. Controlling the surface chemical composition and mastering its modification at the nm-scale are the central issues for high-added value applications involving nanoparticles. Surface-modified silica nanoparticulates and nanofibers have received much interest due to its monodispersity and high degree of shape uniformity. Spherical nanoparticulates are of special interest since they are ideal for acting as ...

• Improving Pulse Synthesis for MRI and other Magnetization Profiling

  Organization: Indiana Univ-Purdue University Indianapolis

  See parent docket P3041.

• Improving Pulse Synthesis for MRI and other Magnetization Profiling

  Organization: Indiana Univ-Purdue University Indianapolis

  Penn researchers have developed a method for RF-pulse sequence design for selective excitation of ensembles of two state quantum systems that allows for careful control of both the magnitude and the phase of the excitation profile. In principle this approach produces RF-pulse sequences of infinite duration, but, empirically they can be truncated without significantly altering the system response. Their approach is based upon an interpretation of the pulse synthesis problem as an inverse scattering problem for the 2 â—Š 2-AKNS system. This ...

• Fluctuation Imaging

  Organization: Indiana Univ-Purdue University Indianapolis

  Researchers at the University of Pennsylvania have invented a technique which uses visible light to quantify and image the flow of blood. The technique employs a source of low-power coherent light, and detects the speckle pattern of the diffusely scatter

• Fluorophore Concentration and Lifetime Images with Diffuse Light

  Organization: Indiana Univ-Purdue University Indianapolis

  Diffusing near IR light has received intense interest as a new medical imaging technique to non-invasively image heterogeneities, i.e. tumors, in biological tissue. Recent developments include the addition of fluorescence based contrast agents with diffu

• An Ophthalmic Augmented Reality Environment

  Organization: Indiana Univ-Purdue University Indianapolis

  Successful laser treatment of ophthalmic disease depends on identifying precisely treatable lesions. To that end, University of Pennsylvania researchers have developed an augmented reality (AR) environment that increases the identifiability of these lesi

• Initial Description of New Compounds and Their Precursors for Positron Emission Tomography of Hypoxia In Vivo

  Organization: Indiana Univ-Purdue University Indianapolis

  Many human and animal diseases are characterized by the pathological formation of tissue hypoxia and ischemia, and treatment of such conditions can only be optimized by determining the extent and degree of hypoxia in the affected tissues of individual pat

• Standardizing MR Image Intensity Scales

  Organization: Indiana Univ-Purdue University Indianapolis

  Magnetic resonance imaging (MRI) is being increasingly used as a diagnostic tool in radiology. A drawback of MRI images is the lack of a standard and quantifiable intensity scale. The image intensity is dependent on both the scanner and patient. Contra

• A Method for PET Detection of Hypoxia

  Organization: Indiana Univ-Purdue University Indianapolis

  Many human and animal diseases are characterized by the pathological formation of tissue hypoxia and ischemia. The preferred treatment of these conditions is often dependent upon the extent of hypoxia in the affected tissues of individual patients. The

• Spin-Lock Imaging

  Organization: Indiana Univ-Purdue University Indianapolis

  Current existing T1r (spin-lock) methods are only able to acquiring single slice images. Additionally, this method is not able to handle 3D or multi-slice imaging and is highly sensitive to radio-frequency homogeneity. University of Pennsylvania research

• Subvoxel Processing: Method for Reducing Partial Volume Blurring in Tomographic Images

  Organization: Indiana Univ-Purdue University Indianapolis

  Currently, partial volume blurring is a problem when the image voxel size is larger than the imaged structural element, a particular issue for in vivo imaging. In an effort to develop a better method of dimensional measurement in such situations, Universi

• Virtual Bone Biopsy (VBB) System

  Organization: Indiana Univ-Purdue University Indianapolis

  University of Pennsylvania researchers have devised a virtual bone biopsy (VBB) data acquisition and analysis system that acquires MR microimages of distal radius or tibial trabecular bone to help evaluate bone diseases, such as osteoporosis and renal ost

• Spiral RF Coil for High Field MRI

  Organization: Indiana Univ-Purdue University Indianapolis

  The signal produced by magnetic resonance imaging devices increases with the strength of the magnetic field. At magnetic fields above 1.5 Tesla, the spatial variation of both the amplitude and phase of the field and the resulting signal will distort the images that are produced. As a result, the improved image quality of high-field devices will not be realized in many parts of the head or body. Researchers at the University of Pennsylvania have modified the design of a low-frequency coil for use at high frequencies. The modified design ...

• Diffuse Photon Density Waves for Object Location with and without Fluorescent Contrast Agents

  Organization: Indiana Univ-Purdue University Indianapolis

  Traditional medical imaging techniques used in CT, MRI, or PET scanning reconstruct an image based on the propagation of unscattered radiation. Researchers at the University of Pennsylvania have invented an imaging system which reconstructs images from mu

• Novel fluorescent probe Cy7-APC

  Organization: Indiana Univ-Purdue University Indianapolis

• Heavy Atom Labeling for High Resolution Structure Determination by Electron Microscopy

  Organization: Indiana Univ-Purdue University Indianapolis

• Catalyzing the Transient Response

  Organization: Indiana Univ-Purdue University Indianapolis

• Dedicated Shim Coils for the Correction of Local MR Field Inhomogeneity

  Organization: Indiana Univ-Purdue University Indianapolis

• Maintaining the alignment of electric and magnetic fields in an x-ray tube operated in a magnetic field

  Organization: Indiana Univ-Purdue University Indianapolis

• MRI: Self-Aligning X-Ray Tube For Use Within an MRI Magnetic Field

  Organization: Indiana Univ-Purdue University Indianapolis

• Method for MRI Velocity Measurements

  Organization: Indiana Univ-Purdue University Indianapolis

• IDEAL&quot; MRI: Multipoint Chemical Shift Decomposition for MRI&quot;

  Organization: Indiana Univ-Purdue University Indianapolis

• Method for Image Reconstruction in Data Sharing Fourier Imaging

  Organization: Indiana Univ-Purdue University Indianapolis

• Two Beam Fluorescence Microscope

  Organization: Indiana Univ-Purdue University Indianapolis

• Scintillation Crystal Detection Arrays for Radiation Imaging Devices

  Organization: Indiana Univ-Purdue University Indianapolis

• Serial Planar Immunofluorescence (SPI) Microscopy

  Organization: Indiana Univ-Purdue University Indianapolis

• Self-complementing firefly luciferase enzyme fragments for studying cellular events in cells and in living animals

  Organization: Indiana Univ-Purdue University Indianapolis

• VEGFR Targeted Imaging and Therapy

  Organization: Indiana Univ-Purdue University Indianapolis

• Assessing genome-wide gene expression by non-invasive imaging

  Organization: Indiana Univ-Purdue University Indianapolis

• Array Tomography

  Organization: Indiana Univ-Purdue University Indianapolis

• Method and Apparatus for Identification of Fluorescence

  Organization: Indiana Univ-Purdue University Indianapolis

• Selective Caspase Binding Agents for Imaging Apoptosis

  Organization: Indiana Univ-Purdue University Indianapolis

• Functional Imaging Method Using FENSI: Flow Enhanced Signal Intensity

  Organization: University of Illinois, Urbana-Champaign

  FENSI differs from other methods in the way that it tags the flowing blood for visualization. It derives signal from blood flowing through a highly localized thin slice at a certain range of velocities within the tissue of interest in the brain. This results in a highly localized representation of flow that is velocity selective and quantified in unties of uL/min/cm2. This could potentially allow scientists to visualize changes in blood flow at the arteriole level--the level of flow control in the brain.

• Single Photon Emission Microscope System for Preclinical Imaging Applications

  Organization: University of Illinois, Urbana-Champaign

• An Ultrasonic Imaging Speckle Suppression and Contrast Enhancement Technique by Means of Frequency Compounding and Coded Excitation

  Organization: University of Illinois, Urbana-Champaign

• Shear Wave Imaging

  Organization: University of Illinois, Urbana-Champaign

• A Novel Mechanism For Semiconductor Gamma-ray Detector Applications

  Organization: University of California, Los Angeles (UCLA)

  This novel design invention is based on a composite layered structure that offers the benefits of high Z gamma-ray absorption combined with excellent charge collection in a much smaller package, which leads to significant improvements on the overall detector performance. The design also enables room temperature operation under reduced voltage, and promises improved energy resolution.

• Biomimetically Inspired Artificial Compound Eyes

  Organization: University of California, Berkeley (UC Berkeley)

• CT - X-Ray Imaging with an MRI System

  Organization: Stanford University

• Dual Gate Oxide Transistors for Downscaling CMOS Image Sensors

  Organization: Stanford University

• MRI - High Order Shimming Using Regularization Methods

  Organization: Stanford University

• Magnetic Resonance Spectroscopic Imaging Method to Monitor Progession and Treatment of Neurodegenerative Conditions

  Organization: Stanford University

• MRI - Magnetic Resonance Imaging Using Spiral FISP with Moment Compensation

  Organization: Stanford University

• MRI - Catalyzing the Transient Response

  Organization: Stanford University

• High Dynamic Range Image Formation and Motion De-blurring in CMOS Image Sensor

  Organization: Stanford University

• Enhancing CMOS Image Sensor Dynamic Range and SNR

  Organization: Stanford University

• MRI - Use of Oscillating Equilibrium SSFP for MR Angiography

  Organization: Stanford University

• MRI - New Methods Used in Diminishing Variance Algorithm

  Organization: Stanford University

• MRI - Variable-Density One-Shot Fourier Velocity Encoding MR Imaging

  Organization: Stanford University

• Medical CAD: Method for Reducing False Positives in Medical Imaging

  Organization: Stanford University

• CT - Volumetric CT

  Organization: Stanford University

• MRI - Dedicated Shim Coils for the Correction of Local MR Field Inhomogeneity

  Organization: Stanford University

• Integrated Color Pixel (ICP)

  Organization: Stanford University

• Reduction of Bulkwave Generation in CMUTS

  Organization: Stanford University

• Capacitive micromachined ultrasonic transducer (CMUT) with varying thickness membranes

  Organization: Stanford University

• CT - Maintaining the alignment of electric and magnetic fields in an x-ray tube operated in a magnetic field

  Organization: Stanford University

• Electrical Through-Wafer Interconnects

  Organization: Stanford University

• Medical CAD/Colonography: Identifying Similar Anatomical Features from Separate Imaging Datasets (Registration of Centerline Paths in Medical Imaging Data)

  Organization: Stanford University

• Medical CAD / Colonagraphy: Automated Differentiation Between Pre-Cancerous Colonic Polyps and Normal Tissue

  Organization: Stanford University

• Medical CAD: An Efficient Colonic Polyp Detection Solution Employing a 3D Free-Form Shape Recognition Approach

  Organization: Stanford University

• CT - A Method for larger Field of View in CT

  Organization: Stanford University

• MRI - Method for Image Reconstruction in Data Sharing Fourier Imaging

  Organization: Stanford University

• MRI - Rapid Measurement of Blood Flow

  Organization: Stanford University

• CT - Improved Sampling in Volumetric CT

  Organization: Stanford University

• Fabrication of CMUTs with Wafer-bond Technology

  Organization: Stanford University

• MRI - Method for MRI Velocity Measurements and 4D Flow software

  Organization: Stanford University

• Tubular Nitinol Mechanisms for an Ultrasound Imaging System of Intravascular Intervention

  Organization: Stanford University

• MRI - "IDEAL" MRI: Multipoint Chemical Shift Decomposition for MRI

  Organization: Stanford University

• A New Regime for Operating Capacitive Micromachined Ultrasonic Transducers

  Organization: Stanford University

• Medical CAD: Automated 3D Characterization of Lesions and Other Biological Structures (derived from a combination different methods including 3D transient thermal profiling)

  Organization: Stanford University

• Medical CAD / Vascular: Quantifying the Infrarenal Aorta and Iliac Arteries

  Organization: Stanford University

• Medical CAD / Vascular: Automated Measurement of Diameters and Volumes of Abdominal Aortic Aneurysms

  Organization: Stanford University

• Medical CAD / Vascular: Intelligent Vascular Separation and Visualisation Algorithm (Curved Slab Maxium Intensity Projections or CS-MIP)

  Organization: Stanford University

• Medical CAD / Vascular: Automated Quantification of Arterial Calcification in CT Studies

  Organization: Stanford University

• Two Beam Fluorescence Microscope

  Organization: Stanford University

• Adaptive Pixel for High Speed, Dynamic Range Imaging

  Organization: Stanford University

• Optimization of Image Sensor Pixels

  Organization: Stanford University

• Addressing CMUT Arrays

  Organization: Stanford University

• High Speed Videography

  Organization: Stanford University

• Medical CAD: Selective Fold Removal in CT Colonography using Physically-Based Simulation

  Organization: Stanford University

• "IDEAL" MRI: Homodyne Reconstruction with Dixon Fat-Water Separation

  Organization: Stanford University

• Matrix Lens System

  Organization: Stanford University

• Medical CAD: Automatic Lung Cancer Diagnostic Software (Monitoring Lung Nodule Growth over a Period of Time)

  Organization: Stanford University

• MRI - MRI: Generalized Image Reconstruction

  Organization: Stanford University

• Propagating Modes in Subwavelength Cylindrical Holes in an Optically Thick Metallic Film

  Organization: Stanford University

• Nonlinear Optical Endoscopy and Microscopy

  Organization: Stanford University

• Capillary for Optical Imaging

  Organization: Stanford University

• MRI - MRI: A Major Speed Increase for Banding Artifact Elimination in SSFP-MRI Utilizing the Super Field of View (sFOV) Technique

  Organization: Stanford University

• Scatter Correction Algorithm for X-ray and Volumetric CT

  Organization: Stanford University

• Simple technique to retrieve phase and magnitude of weak ultrashort laser pulses using a stronger unknown pulse

  Organization: Stanford University

• Serial Planar Immunofluorescence (SPI) Microscopy

  Organization: Stanford University

• MRI - Steady-State Free-Precession MRI with Significantly Increased Signal Bandwidth

  Organization: Stanford University

• Method to measure image density of digitized photographs for X-ray analysis

  Organization: Stanford University

• Anatomy-Based Radiograph Labeling and Retrieval

  Organization: Stanford University

• Accelerated tomographic image reconstruction algorithms on Graphics Processing Units (GPU)

  Organization: Stanford University

• MRI - An Apparatus To Perform Motion Corrected Magnetic Resonance Imaging

  Organization: Stanford University

• MRI - "IDEAL" MRI: Self-Calibration Methods for Parallel Imaging and Multi-Point Water-Fat Separation Methods

  Organization: Stanford University

• Tomographic Reconstruction for X-Ray Cone-Beam Scan Data

  Organization: Stanford University

• MRI - "IDEAL" MRI: Calibration Maps for Parallel Imaging Free of Chemical Shift Artifact

  Organization: Stanford University

• MRI - "IDEAL" MRI: Weighted Least-squares Water-Fat Separation

  Organization: Stanford University

• MRI - "IDEAL" MRI: Regularized Water-Fat Separation

  Organization: Stanford University

• MRI - "IDEAL" MRI: Sliding Window Reconstruction and Phase/Field Map Updating for Chemical Shift Imaging

  Organization: Stanford University

• "IDEAL" MRI: Methods for Combining Separate Water and Fat Images and Quantifying Fat

  Organization: Stanford University

• MRI - "IDEAL" MRI: Simultaneous T2* Measurement and Correction in Chemical Shift Imaging

  Organization: Stanford University

• Moving Table MRI with Frequency-Encoding in the Z-Direction

  Organization: Stanford University

• MRI - Fast Metabolic Imaging of Systems with Sparse Spectra

  Organization: Stanford University

• Medical CAD: Global Optimization Using Learning Enhanced Simulated Annealing (LESA); for lung CAD

  Organization: Stanford University

• Acoustic Cross Talk Reduction Method

  Organization: Stanford University

• 3-D Adaptive Filtering of Projection Data for Noise Reduction in Low-dose C-arm

  Organization: Stanford University

• Trench Isolated CMUT Arrays

  Organization: Stanford University

• MRI - Multi-resolution robust field map estimation for water and fat separation

  Organization: Stanford University

• MRI - Inverted Double Half RF Pulse for Ultrashort T2 Imaging

  Organization: Stanford University

• Rotational Stereo Roadmapping for navigating interventional radiology instrument

  Organization: Stanford University

• Multifunctional metal-graphite nanocrystals

  Organization: Stanford University

• A Method for Parallel Imaging with Calibration to a Separate Coil

  Organization: Stanford University

• A Method for Magnetic Resonance Image Reconstruction using Correlation Values

  Organization: Stanford University

• A Method for Magnetic Resonance Image Reconstruction with Parallel Imaging and Motion Correction

  Organization: Stanford University

• Array Tomography

  Organization: Stanford University

• MRI - 3D Cones Gradient Waveform Generation Software

  Organization: Stanford University

• CT - Raw Data Normalization in Inverse Geometry CT

  Organization: Stanford University

• MRI - Water and Fat Separation with Bipolar Multi-Echo Sequences

  Organization: Stanford University

• MRI - An auto-calibrating parallel imaging reconstruction method from arbitrary k-space sampling

  Organization: Stanford University

• MRI - A Fast Method for Designing Time-Optimal Gradient Waveforms for Arbitrary k-Space Trajectories

  Organization: Stanford University

• MRI - Slice-selective Tunable AdiaBatic Low peak Power Excitation (STABLE) pulse

  Organization: Stanford University

• Highly Fluorescent Magnetic Nanoprobes

  Organization: Stanford University

• Laser-driven deflection structure for charged particle beams

  Organization: Stanford University

• MRI - Motion Corrected Diffusion Tensor MRI

  Organization: Stanford University

• Method and Apparatus for Identification of Fluorescence

  Organization: Stanford University

• Fabrication of CMUTs

  Organization: Stanford University

• Robust Motion Correction Algorithm for Functional Magnetic Resonance Imaging

  Organization: Stanford University

• MRI - Multiple Repetition Time Steady-State Free Precession Imaging

  Organization: Stanford University

• A novel scheme of cone-beam CT imaging in radiation therapy

  Organization: Stanford University

• iPad: An Annotation Tool for Radiology Images

  Organization: Stanford University

• A noninvasive in vivo assay of inflammation and infection using hyperpolarized 13C magnetic resonance imaging.

  Organization: Stanford University

• Monolithic Integrated CMUTs Fabricated by Low-Temperature Wafer Bonding

  Organization: Stanford University

• Synchronous Method for Registering Anatomic Mapping Data to Models of the Anatomy

  Organization: Stanford University

• Directly Fabricated Nanoparticles for Raman Scattering

  Organization: Stanford University

• Micromachined Ultrasonic Transducer Having Compliant Post Structure

  Organization: Stanford University

• MRI - Method for Optical Pose Detection

  Organization: Stanford University

• Shift-Varying Line Projection using Graphics Hardware

  Organization: Stanford University

• Devices and Methods for X-ray Molecular Imaging Enabled by Biocompatible Nanophospher Imaging Agents

  Organization: Stanford University

• MRI - Contrast and Resolution Enhancement for Magnetization-Prepared MRI with Signal Compensation

  Organization: Stanford University

• Brain Tissue Quantification and Segmentation Using MRI

  Organization: Stanford University

• Medical Screening and Diagnostics Based on Air-Coupled Photoacoustics

  Organization: Stanford University

• Improved CT Imaging Through Simultaneous Acquisition of Scatter and Image Projection Data

  Organization: Stanford University

• Multimodal DAC Microendoscope Platforms

  Organization: Stanford University

• Algorithm to Reduce Artifacts in 4D Computed Tomography

  Organization: Stanford University

• Behavioral Biomarker and Training Method for Diagnosis and Treatment of Anxiety & Depression

  Organization: Stanford University

• Planar Near Field Optical & Force Microscope

  Organization: Stanford University

• CMOS Area Image Sensor with Pixel Level A/D Conversion

  Organization: Stanford University

• MRI - Spiral Projection-Reconstruction Hybrid K-Space Trajectory

  Organization: Stanford University

• MRI: Method for Correcting Field Inhomogeneity Distortion in MRI

  Organization: Stanford University

• Method for improved temporal resolution in MR fluoroscopy

  Organization: Stanford University

• Novel fluorescent probe Cy7-APC

  Organization: Stanford University

• High-speed Inter-modality Image Registration via Iterative Feature Matching

  Organization: Stanford University

• Medical CAD: Method for Separating Objects from Background in Digital Images

  Organization: Stanford University

• Serial Analog-to-Digital Converter Using Successive Comparisons

  Organization: Stanford University

• Microfabrication of Sealed Membranes and their Applications

  Organization: Stanford University

• MRI - A Method for MR system eddy-current measurement

  Organization: Stanford University

• Improved Microfabrication of Acoustic Transducers

  Organization: Stanford University

• MRI - Phase Compensating RF Pulses for Magnetic Resonance Imaging and Spectroscopy

  Organization: Stanford University

• Converting a Low Dynamic Range Analog Signal to Large Dynamic Range Digital Floating Point Representation

  Organization: Stanford University

• MRI - Spatiotemporal Finite Element Method for Motion Analysis with Velocity Data

  Organization: Stanford University

• MRI - Removal of Interventional MR Device Distortion

  Organization: Stanford University

• Simultaneous Multi-Channel bit Serial Multiplication and Quantization

  Organization: Stanford University

• MRI - Non-Invasive Measurement of Frozen Tissue Temperature using MRI

  Organization: Stanford University

• MRI - Temporally Resolved, Three-dimensional MR Volume Acquisitions

  Organization: Stanford University

• Sagnac Acoustic Fiber Sensor Array

  Organization: Stanford University

• Common-Path Interferometric Sensor Array

  Organization: Stanford University

• Heavy Atom Labeling for High Resolution Structure Determination by Electron Microscopy

  Organization: Stanford University

• Minimum cost solenoid magnet and method of making same

  Organization: Stanford University

• MRI - Homogeneous Electromagnet for Prepolarized MRI

  Organization: Stanford University

• MRI - A Bipolar Magnet Configuration

  Organization: Stanford University

• MRI - More Efficient Data Encoding in Dynamic Magnetic Resonance Imaging

  Organization: Stanford University

• Medical CAD: Osteoporosis Screening Breakthrough using QCT (Quantitative CT) on Conventional Clinical Scanners

  Organization: Stanford University

• MRI - Phase-sensitive Method of Radio-Frequency Field Mapping for Magnetic Resonance Imaging

  Organization: Stanford University

• MRI - A Reduced Field-of View Method to Increase Temporal Resolution or Reduce Scan Time in CINE Magnetic Resonance Imaging

  Organization: Stanford University

• MRI - Linear Combination Steady-State Free Precision MRI

  Organization: Stanford University

• Through Wafer via Connections

  Organization: Stanford University

• Cross Talk Reduction in cMUTs

  Organization: Stanford University

• CMOS Image Sensor with Self Reset Pixel Architecture

  Organization: Stanford University

• MRI - Magnetic Resonance Imaging Using Off-Centered Spiral Trajectories

  Organization: Stanford University

• MRI: Transmission Line Techiques for MRI Catheter Coil Miniaturization and Tuning

  Organization: Stanford University

• Integrated Array of Image Sensors

  Organization: Stanford University

• CMOS Video Sensor System with Improved SNR Under Low Illumination

  Organization: Stanford University

• Method for Adaptive Spectral Sensing

  Organization: Stanford University

• MRI - Real-time Gridding Reconstruction Server

  Organization: Stanford University

• MRI - Real-time Interactive Pulse Sequence

  Organization: Stanford University

• Compact transform spectrometer based on sampling a standing wave

  Organization: Stanford University

• Novel Compounds for the Antemortem Diagnosis of Alzheimer's Disease

  Organization: University of Pittsburgh

• Hybrid Film to Monitor Interface During Simultaneous Side by Side Review of Both

  Organization: University of Pittsburgh

• A Computer Vision Based Device for Detecting Patient Motion During Radiotherapy Treatment

  Organization: University of Pittsburgh

• Holographic Opitcal Elements to see through opaque material

  Organization: University of Pittsburgh

• Skull Stripping Program Based On Watershed Transform with Adaptive Threshold and Restraining the Non-cortex Basin from Merging Neighbor Basins

  Organization: University of Pittsburgh

• Acquisition-weighted stack of spirals for fast ultrashort-TE MR imaging

  Organization: University of Pittsburgh

• A RF transmit/receive coil system for C-13 and H-1 magnetic resonance spectroscopy and imaging of human breast at high field (7T and 3T)

  Organization: University of Pittsburgh

• Bi-Plane X-Ray Imaging System

  Organization: University of Pittsburgh

• Imaging of oxidated disulfides in proteins in histological samples

  Organization: University of Pittsburgh

• A Recovery Method of Signal Loss Due to Susceptibility in Echo Planar Imaging of Magnetic Resonance Imaging

  Organization: University of Pittsburgh

• Novel Method to establish Backward Compatibility between Time Domain Optical Coherence Tomography (TDOCT) and Spectral Domain Optical Coherence Tomography (SDOCT)

  Organization: University of Pittsburgh

• Stem Cell Tracking Using Ultrasound

  Organization: University of Pittsburgh

• Detection of Breast Cancer using MRSI

  Organization: University of Pittsburgh

• A Photobaric Detector

  Organization: Oklahoma State University

• 2008-063 PEG Nanocarriers, Nanogels and Synthesis Methods

  Organization: Rutgers University

• 2010-081 PEGTides-Novel PEG-based Dendrons for Efficient Drug Delivery and Imaging Tools

  Organization: Rutgers University

• 2008-081 Degradable Hydrogels

  Organization: Rutgers University

• Gastrointestinal Tract Unraveling with Curved Cross-Sections

  Organization: University of Iowa Res Foundation

• Clinical Radiology Software for MR Urography

  Organization: Children's Hospital Los Angeles

• Identification of Cells with a Compact Microscope Imaging System with Intelligent Controls

  Organization: NASA Glenn Research Center

• Measuring Protease Activity Using Quantum Dot Probes

  Organization: Rice University

• Method for non-invasive, non-destructive, accurate testing of mechanical properties via ultrasound

  Organization: Columbia Tech Ventures

• Simultaneous Indentification of Fingerprints and Mapping of Blood Vessels in a Finger

  Organization: University of Massachusetts Lowell

• Super-resolution Optical Genome Sensing and Sequencing

  Organization: Rice University

• Standing Wave Axial Nanometry (SWAN) for Superresolution Microscopy

  Organization: Iowa State University

• Two rapid, reversible optical clearing methods for clearing brain tissue while preserving tissue properties

  Organization: Columbia Tech Ventures

• Diffuse Lighting System for Machine Vision Applications

  Organization: Columbia Tech Ventures

• A Design for a Diffuse Optical Tomography Probe for Brest Cancer Imaging

  Organization: Columbia Tech Ventures

• Wireless Handheld Optical Probe for Brest Cancer Imaging

  Organization: Columbia Tech Ventures

• Novel Simplified Optics Retinal Camera

  Organization: Columbia Tech Ventures

• Diagnosis of neuropsychiatric disorders using magnetic resonance imaging

  Organization: Columbia Tech Ventures

• Optical Tomographic Imaging System for Joint Disease

  Organization: Columbia Tech Ventures

• Methods of preparing targeted microbubble shells

  Organization: Columbia Tech Ventures

• Protein shelled microbubbles for intravenous oxygen delivery

  Organization: Columbia Tech Ventures

• Methods, Systems and Devices for Manufacturing and Long-Term Storage of high concentration suspension of Microbubbles

  Organization: Columbia Tech Ventures

• Probing RNAs

  Organization: Columbia Tech Ventures

• Method for 3-D detailed tissue imaging from 2-D fluorescence emission data

  Organization: Columbia Tech Ventures

• Three Dimensional Imaging of Living Tissues with Hyperspectral Excitation-Resolved Fluorescence Tomography

  Organization: Columbia Tech Ventures

• Hyperspectral In-Vivo Two-Photon Microscopy of Intrinsic Fluorophores

  Organization: Columbia Tech Ventures

• Heart Geometrical Measurements

  Organization: Columbia Tech Ventures

• Ginkgolide Compounds, Compositions, Extracts and Uses Thereof

  Organization: Columbia Tech Ventures

• Ordered data compression system and methods

  Organization: Columbia Tech Ventures

• Imaging method and system

  Organization: Columbia Tech Ventures

• Anatomically correct prosthesis and method and apparatus for manufacturing prosthesis

  Organization: Columbia Tech Ventures

• Protein shelled microbubbles for intravenous oxygen delivery

  Organization: Columbia Tech Ventures

• Photoacoustic Array System

  Organization: University of Alberta

  Byadjusting the speed of sound parameter common in most commercial ultrasound systems, researchers at the University of Alberta have made it possible toobtain a good quality ofphotoacoustic imaging with built-in ultrasound beamforming hardware. This speeds up significantlythe development time for photoacoustic imaging implementation, and gives access to features like parallel beamforming. Ultimately, the application of this novel technique gives the developed photoacoustic imaging system all the advantages provided by the custom ultrasound ...

• Photoacoustic Deep Tissue Imaging

  Organization: University of Alberta

  Researchers at the University of Alberta have developed a novel imaging technique that uses the human form of the tyrosinase gene as a reporter gene for photoacoustic imaging. Using this technology, cells transfected with plasmids encoding encoding tyrosinase could be imaged in tissues (at depths up to 4 centimeters) using photoacoustic imaging, potentially allowing for the non-invasive visualization of tumor cells expressing tyrosinase in living subjects. With this technology, tumor growth rates and tumor cell migration may be imaged at ...

• Fullerene-Based Contrast Agent for X-Ray Imaging

  Organization: Rice University

• Length-Selective Extraction of Single-Walled Carbon Nanotubes

  Organization: Rice University

• System and Method for Automatic Placement of Spatial Suppression Regions in Magnetic Resonance Imaging and Magnetic Resonance Spectroscopic Imaging

  Organization: STC UNM

  A novel method for imaging an organ comprising the steps of: Aligning the organ with a standardized organ using automated methodsSpatially normalizing the standardized organ (spatial co-ordinates and angles of suppression) to the individual subject’s organ using conventional spatial normalization techniquesProviding optimized suppression slice positions in reference to a standardized organ (e.g. atlas) Translating optimized suppression slices of standardized organ into optimized slices of the individual’s organ; andImaging the organ ...

• Ratiometric Method for Non-linear Coherent Imaging

  Organization: STC UNM

  This invention provides a novel method to generate image contrast by taking the ratio of signals produced at different sum/difference frequency combinations. This method is powerful for generating image contrast because the ratio, and thus the image itself, are affected by the detailed structure of the molecular/atomic energy levels. For this reason, the disadvantages of CARS and SPF methods are avoided.

• In-Vivo Fiberoptic Probe for Intra-operative Fluorescence Quantification in Tissue

  Organization: University Health Network

  UHN’s biophotonics group has developed a fiberoptic probe that quantitatively measures the fluorescence in tissue for in-vivo surgical applications which compensate for the effects of tissue optical property variations. One of the major difficulties in using fluorescence for medical diagnostics and therapeutics is quantifying the fluorescence in tissue.Fluorescence signals are strongly affected by variations in the tissue optical properties whereas the objective of the clinician is often to quantify the fluorescence based on fluorophore ...

• Synthetic Echo-Time Viewing Technique and Software for MR Imaging

  Organization: University Health Network

  Researchers at UHN have developed a post-processingtechnique for magnetic resonance imaging which allows auser to selectively vary the imaging “synthetic” echo-time(TE) dynamically through a range of echo-time values inan analogous way as “windowing and leveling” features inviewers. This is performed with only a single T2 map ofthe anatomy at a singe given TE. In routine spin-echo or fast spin echo MR imaging, tissuecontrast is governed by the TE. By an appropriate choiceof TE, the contrast between native tissue and pathologymay be optimized. ...

• Sub-Surface Fluorescence Topography (SSFT) for Depth-resolved Fluorescence of Buried Pathologies

  Organization: University Health Network

  UHN’s biophotonics group has developed a wide-field fluorescence technique and instrument which is able to provide a map of fluorescence buried underneath the surface of tissue in a depth-resolved fashion. The technique is called Sub-Surface Fluorescence Topography (or SSFT) with the primary application being detection of fluorescently-labeled cancer tumors or other pathologies of interest which reside beneath the surface.The instrument extracts information of the sub-surface fluorescence and is able to reconstruct topographical maps of the ...

• Fluorescence Quantification for Image Guided Surgery

  Organization: University Health Network

  Investigators at the University Health Network have recently developed a novel low-cost method and device that can measure the signals originating from a fluorescent biomarker in a patient and display them in a quantitative real-time, high resolution format. Healthy tissue preservation is of the utmost importance when performing re-sectioning procedures–especially in the brain and eye. Presently, the practice of using fluorescent biomarkers in combination with 'image-guided surgery' is based only on qualitative validations. As a result, ...

• 3D CT Images Reconstructed from 4D CT Data

  Organization: University Health Network

  Investigators at the University Health Network have recently developed a novel method to obtain high quality, clinically useful 3D static computed tomography (CT) volumes from relatively low quality 4D data, thus allowing clinicians to obtain the benefits of both 3D and 4D imaging from a single scan. Currently, radiologists need to perform two independent intravenous contrast agent enhanced CT scans to obtain diagnostic quality functional and anatomic information for diagnoses such as stroke, tumor or organ perfusion, vasospasm, and ...

• A Forward-viewing Intravascular Imaging and Guided Therapeutic Intervention

  Organization: University Health Network

  This technology provides a forward-looking imaging platform that enables cardiovascular and other restricted space catheter-based interventions and image-guided therapy. Market NeedAlthough side-viewing OCT/ultrasound catheter, endoscopic and angiography techniques are already established in clinics and surgical suites, there is currently no imaging platform that is small, sensitive and robust enough to be used in forward-viewing intravascular applications. As a result, there is an entire class of indications, including vessel occlusions that ...

• TANDEM IMAGING SYSTEM: Real-time Imaging During Radiation Therapy Treatment

  Organization: University Health Network

  Image guided radiotherapy (IGRT) was recently adopted due to changes in organ-filling or breathing movement during radiotherapy. The technology allows for imaging information from the “planned CT” scan performed earlier in the treatment process to be overlapped with a CT image that is taken immediately before treatment delivery. Unfortunately, the current system cannot track tumor movement due to breathing during the treatment - thus variability in the dose delivered still exists. A group of UHN radiation treatment specialist has developed a ...

• High Precision Radiostereometric Analysis (RSA) System for Monitoring Micro-Movement in Orthopedic Implants

  Organization: WORLDiscoveries - University of Western Ontario

  We have developed a new universal RSA calibration system that eliminates the need for joint-specific calibration boxes and analysis. It has been optimized to be 40% and 70% more accurate than other existing technologies (Biplanar and Uniplanar respectively) and is readily adaptable to RSA suites already in use. Finally, the analysis software, which has been optimized to the system, is modular, and fully complements existing x-ray detection systems and data formats. The new RSA system has been validated, satisfies the need for universality, ...

• Flexible BioElectronic Photodetector and Imaging Arrays

  Organization: WORLDiscoveries - University of Western Ontario

  Description of the Invention The invention relates to the design and fabrication of photodetector arrays and non-traditional imaging systems that exploit bacteriorhodopsin (bR) thin films and flexible printed electronic circuits. To create this novel technology, purple membrane (PM) patches obtained from wild-type bR are deposited onto a polyethylene terephthalate (PET) substrate coated with a patterned indium-tin-oxide (ITO) layer using the Electrophoretic Sedimentation (EPS) technique. A conductive ITO layer is deposited onto the ...

• IMG-007 - ULTRASOUND - 3D Ultrasound- Guided Method for Prostate Brachytherapy

  Organization: WORLDiscoveries - University of Western Ontario

  Prostate brachytherapy is a type of radiation therapy where radiation “seeds” are strategically placed within the prostate gland or as close as possible to the tumor. Clinical data have shown prostate brachytherapy to be as effective as traditional surgery with fewer long-term side effects (e.g., incontinence, impotence). Original methods of prostate brachytherapy involved surgical exposure of the prostate gland followed by the freehand insertion of seeding needles. Aside from problems associated with the invasiveness of ...

• 3-D Scanner

  Organization: WORLDiscoveries - University of Western Ontario

  We have developed a hand-held scanner and technique to measure and acquire 3-D surface shape, in order to generate a 3-D model of an object or environment. The scanner is a freely moving hand-held sensor that performs the measurement without contacting the object. It does not require tracking by any secondary tracking or positioning device, and does not require surface markers to be placed on the object being measured. The hand-held range sensor consists of a laser projector and a CCD camera to capture the pattern of lines formed on the ...

• Ghrelin Analogues as Molecular Imaging Probes

  Organization: WORLDiscoveries - University of Western Ontario

  Ghrelin is the natural ligand for the GHSR. Ghrelin binds to the GHSR with high affinity and specificity, resulting in a ghrelin-GHSR complex that is internalized. This binding and internalization of the ghrelin-GHSR complex is exploited through the design of a class of ghrelin-based imaging agents targeting GHSR. Through competitive binding assays it has been demonstrated that these imaging probes have strong affinity to the desired receptor target, GHSR. These probes are suitable for the non-invasive imaging of tumours expressing GHSR ...

• Electrostatic Microactuator For Phase Micromirror Arrays

  Organization: University of California, Berkeley (UC Berkeley)

• Axial Light-force Sensor

  Organization: University of California, Berkeley (UC Berkeley)

• Biocompatible Nanostructures For Ultrasensitive Biomolecular Sensors And Cellular Imaging

  Organization: University of California, Berkeley (UC Berkeley)

• Targeted Delivery to the Heart Endothelium

  Organization: University of California, Davis (UC Davis)

  Ligand-targeted liposomes are increasingly being recognized as an effective strategy to deliver drugs to specific organs; however, few studies have quantified endothelial binding of targeted liposomes. Researchers at the University of California, Davis have discovered that embedding high concentrations of short, linear, arginine-terminated peptides into nanoparticles allows for concentrated binding of the particles selectively to heart endothelium and the vascular endothelium in the heart.

• Improved MEMS Phase-shifting Interferometer

  Organization: University of California, Berkeley (UC Berkeley)

• Magnetometer With Improved Spatial Resolution

  Organization: University of California, Berkeley (UC Berkeley)

• Image-based Object Recognition System

  Organization: University of California, Berkeley (UC Berkeley)

• High-throughput Cell Measurements

  Organization: University of California, Berkeley (UC Berkeley)

• Integrated Microfluidic Cell Analysis System

  Organization: University of California, Berkeley (UC Berkeley)

• Remote Optical Nano Switch For Localized Control Of Gene Interference

  Organization: University of California, Berkeley (UC Berkeley)

• Truncated Streptavidin And Fusion Proteins Thereof / Metal Binding Chimeric Protein With Biological Recognition Specificity

  Organization: University of California, Berkeley (UC Berkeley)

• A Novel RGD-Containing Cyclic Peptide for use in Cancer Imaging and as a Targeted-Therapy Ligand

  Organization: University of California, Davis (UC Davis)

  The compound has the ability to bind to target αvβ3 integrin on tumor cells and neovasculatures and can be used in tumor diagnostic imaging and therapy. This compound outperforms existing commonly used RGD ligands in both targeting efficacy and lower non-specific binding to normal organ tissues. The compound can be easily functionalized to conjugate imaging payload without decreasing binding strength. The compound bound αvβ3 integrin as evidenced by stained glioblastoma U-87 MG cells and melanoma A375M cells. The ...

• Novel Orally Active 1,4-di-substituted-3-hydroxy-2(1h)- Pyridinonate Chelating Agents

  Organization: University of California, Berkeley (UC Berkeley)

• MEMS Microscanners For Optical Scanning Applications

  Organization: University of California, Berkeley (UC Berkeley)

• Method For In Vivo Monitoring Of Sulfotransferase Activity and Compounds to Label Brain Beta-Amyloid Plaques in Alzheimer's Disease

  Organization: University of California, Los Angeles (UCLA)

  UCLA researchers have developed a novel method for the detection and monitoring of SULT activity in vivo. Through the use of SULT substrates in conjunction with positron emission tomography (PET), it is now possible to monitor SULT activity in vivo. In addition, investigators have developed DDNP, a compound, when labeled with positron emitters, can detect in vivo the presence of beta-amyloid plaques in the human brain due to its ability to easily cross the BBB.

• A Novel High Resolution Scintillation Detector

  Organization: University of California, Los Angeles (UCLA)

  This invention overcomes the above limitations of high cost, limited spatial and energy resolutions, and limited signal-to-noise ratio of conventional PMT-based PET detector designs with the use of semiconductor photodetectors (SPD) to detect the scintillation light. SPDs, such as silicon avalanche photodiodes, for example,together with previously developed readout electronics, are a significantly lower cost alternative to PMTs. In addition, because the SPD is highly compact, the development of a high spatial resolution, high efficiency ...

• Transgenic Mice with Prostate-specific Reporter Gene Expression

  Organization: University of California, Los Angeles (UCLA)

  Scientists at UCLA have developed a transgenic mouse that allows for the direct imaging of the mouse prostate without invasive surgery. By placing a reporter gene under the control of an androgen-specific promoter the transgenic mouse over-expresses the reporter gene specifically in the prostate of the mouse. Thus reporter levels serve as an in situ indicator of androgen-mediated activation of the AR. Detection of the reporter is achieved through the use of commercially available devices. These mice can also be crossed with the c-Myc mouse ...

• Volumetric Analysis Of Multi-dimensional Images

  Organization: University of California, Los Angeles (UCLA)

  Researchers at UCLA have identified a modified illusory surface algorithm that uses the curvature and a few points on the surface of an irregular 3D object to accurately calculate its volume. By segmenting images given to the computer using user-selected points, the algorithm quickly and accurately obtains geometrical information about the structure with minimal user interaction. After the algorithm has calculated its estimate of the volume, a new image can be generated with the calculated data for comparison to the original image, verifying ...

• Engineered Antibody-Quantum Dot Conjugates (immunoqdots) For Cancer Marker Detection

  Organization: University of California, Los Angeles (UCLA)

  Researchers at UCLA have modified quantum dots with tumor-specific engineered antibody fragments for in vitro and in vivo imaging of antigen surface markers on tumor cells.

• SPIN-LOCK MAGNETIC RESONANCE ANGIOGRAPHIC AND PERFUSION IMAGING METHOD

  Organization: University of California, San Francisco (UCSF)

• Improved Needle Tip Visibility for Ultrasound-Guided Anesthesia Delivery

  Organization: University of California, San Francisco (UCSF)

• A Novel Trigger Molecule for the Detection and Treatment of Cancer

  Organization: University of California, San Francisco (UCSF)

• Simplified One Pot Synthesis Of [18F]SFB For Radiolabeling

  Organization: University of California, Los Angeles (UCLA)

  UCLA researchers have developed a novel procedure to synthesize [18 F]SFB that reduces its inherent complexity, improves radiochemical yields, and reduces the overall reaction time. In contrast to other methods reported in literature, this new process is performed using only one reactor and one solid-phase extraction (SPE) cartridge for final purification. Most importantly, this simplified synthesis is ready to be automated. The development of an automated [18 F]SFB synthesizer is critical because it will enable many biologists ...

• A New Format For Representing And Encoding Images

  Organization: University of California, Los Angeles (UCLA)

  Researchers at UCLA have circumvented this serial procedure and developed a method for encoding images that require a much smaller file size. Their technique is based on the development of a primal sketch which is extracted from an image based on the portion of the image with distinguishable elements. A library is generated from these elements which can then be applied to the entire image for compression. In addition, because the method is evaluative and retains key features of the original image, it benefits subsequent image processing ...

• Magnetic Resonance Microcoil Useful In Research, Diagnosis And Disease Treatment

  Organization: University of California, Los Angeles (UCLA)

  Researchers at UCLA have developed a magnetic resonance microcoil with a high signal-to-noise-ratio per-unit-volume that enables microscopic imaging and spectroscopy. A microcoil is a small solenoid that can be used to target small tissue samples for enhanced magnetic resonance signal reception. The sensitivity of microcoils increases as the solenoid diameter is reduced, thereby making the microcoil especially amenable to small bioimaging probes. The device can be used in research, diagnosis, and treatment planning for diseases such as ...

• Inclined Single Plane Imaging Microscope Box (iSPIM Box)

  Organization: University of California, Irvine (UC Irvine)

  iSPIM Box is intended for imaging biological samples with a fast volumetric acquisition and offers numerous advantages over existing technologies, such as the confocal microscope principle which has been combined with spinning disk technology and very fast laser scanning microscopes to yield 3D microscopy images, but results in problems with photo-bleaching and energy load. Light-sheet microscopy techniques decrease the photo-bleaching and energy load problems inherent in confocal microscopes, but introduce new disadvantages. Specifically, ...

• Human Protein Scaffold With Controlled Serum Pharmacokinetics

  Organization: University of California, Los Angeles (UCLA)

  Researchers at UCLA have identified a specific domain of a prevalent human protein, and novel conserved mutations within that domain, that has the ability to modify and/or extend the serum half life of an attached molecule such as a tumor targeting molecule (peptide, aptamer, or small chemicals), imaging agent, or a therapeutic functional group.

• Recombinant Luciferase Gene, Luciferase Fusion Proteins, and Methods of Use

  Organization: University of California, San Diego (UC San Diego)

  Researchers at UC San Diego have been awarded three U.S. patents for the production of recombinant Coleoptera luciferase (U.S. patent number 5,583,024), their hybrid proteins (U.S. patent number 5,674,713), mutated proteins (U.S. patent number 5,700,673), and their uses as reporter molecules. The patent claims cover compostitions and methods to produce recombinant Coleoptera luciferase and hybrid proteins from either RNA or DNA templates. The recombinant luciferase can be expressed in procaryotic or eucaryotic cells, lysates of those cells, ...

• A New Method To Reduce Radiation Dose In Multidetector CT While Maintaining Image Quality

  Organization: University of California, Los Angeles (UCLA)

  UCLA scientists have developed a method to specifically reduce radiation dose to selected organs during a conventional helical CT scan performed on a patient. This innovation exploits the significant dose variations when CT scanning is performed to reduce dose to targeted radiosensitive organs solely by varying the tube start angle in CT scans.

• A Method And Software To Generate X-Ray Source Models For Multidetector CT Scanners

  Organization: University of California, Los Angeles (UCLA)

  UCLA scientists have developed a method and written software for generating x-ray source models for performing MC radiation dosimetry simulations of multidetector CT (MDCT) scanners. The x-ray source models developed by this method are based solely on measured values, and eliminate the need for access to proprietary data.

• Acoustic Daylight Imaging

  Organization: University of California, San Diego (UC San Diego)

  A new acoustic technique for providing real-time visual images of the interior of the ocean has been invented by a researcher at Scripps Institution for Oceanography. The imaging process relies on ambient noise, or "acoustic daylight," as the source of illumination with the underlying idea being analogous to photography in the atmosphere with daylight illuminating the subject. An object in the noise field scatters the incident sound and the scattered field is focused with an acoustic lens to form an image on an array of transducers. After ...

• Ultrahigh Resolution Multicolor Colocalization Of Single Fluoresecent Probes

  Organization: University of California, Los Angeles (UCLA)

  UCLA investigators have developed a novel imaging and ultrahigh-resolution colocalization technique that can pinpoint the location of multiple distinguishable probes with nanometer accuracy and perfect registry. Based on sample-scanning confocal microscopy, it uses a single excitation laser and a closed-loop piezo-scanner that allows for nanometer accuracy steps. Also, this invention utilizes point-like fluorescent probes that can all be excited by the same laser wavelength but differ in their emission properties (i.e., semiconductor ...

• Bioactivation And Surface Properties Modulation Of Inorganic Nanoparticles

  Organization: University of California, Los Angeles (UCLA)

  The invention allows inorganic particles to be used in biological systems. By attaching specialized peptides to the surface of the particle, this invention allows these inorganic particles to take on biologically important functions. It provides water solubility and bioactivity to inorganic, metallic, and semiconducting nanoparticles as well as organic particles. The peptides also have a functional end that allows for adjusting the nanoparticles' targeting capabilities by way of interchangeable sequences. Thus, in line with the example above, ...

• A MRI Arterial Spin Labeling Software for Quantification of Regional and Complete Pulmonary Blood Flow

  Organization: University of California, San Diego (UC San Diego)

  UC San Diego researchers have developed a reliable MRI ASL pulse-sequence software to measure the PBF, with the entire imaging sequence being completed in one single breath-hold. It is based on the algorithm described in the published paper by Bolar et. al. (referenced below). Regional PBF can be quantified using an ASL-FAIRER (flow-sensitive alternating inversion recovery with an extra RF pulse) technique coupled with the single-subtraction approach of using one tag-control pair acquisition at an inversion time (TI) matched to the ...

• A Novel Positron Emission Tomography Probe for Imaging Liver Disease and Metabolic Imbalance

  Organization: University of California, Los Angeles (UCLA)

  Professor Owen Witte and colleagues at the UCLA Department of Molecular and Medical Pharmacology have developed a new PET probe designed to image ribose metabolism in vivo. Initial studies in mice demonstrate that it specifically localizes to the liver. Moreover, researchers observe that its uptake in the organ depends on a healthy metabolic state, demonstrating its potential utility as an indicator of metabolic dysfunction.

• Fluorescent Amyloid Binding Agents for Diagnosis of Alzheimer's Disease

  Organization: University of California, San Diego (UC San Diego)

  A common structural feature of known amyloid-binding agents is an electronically-polarized, extended aromatic system that is inherent to a family of fluorescent probes known as molecular rotors. Features of molecular rotors, which inherently decrease the non-radiative decay rate and increase fluorescence emission upon binding to aggregated beta-amyloids, were incorporated into a general design of novel, amyloid-binding agents.

• A Novel Approach for Lower Energy Dynamic Cardiac Imaging with MRI

  Organization: University of California, Los Angeles (UCLA)

  Dr. Daniel Ennis and colleagues in UCLA’s Department of Radiological Sciences have developed a novel MRI protocol that allows 2D and 3D cardiac CINE imaging with high-field MRI.  The unique scheme maintains image contrast using 3T MRI while reducing the rate of tissue energy absorption by up to a factor of 3.5, thereby overcoming the safety concerns of tissue heating.  Computer simulations and tests in humans have demonstrated that the new scheme can be used to produce high resolution images.       

• A Supramolecular Approach For Preparation Of Size-Controllable Nanoparticles

  Organization: University of California, Los Angeles (UCLA)

  UCLA scientists have developed a supramolecular approach for the preparation of size-controllable nanoparticles from three specific molecular (nano) building blocks. This approach offers synthetic convenience, flexibility and modularity of the size and surface chemistry of the nanoparticle. Nanoparticles with controllable sizes between 30 and 350nm have been obtained. These nanoparticles can be used for the assembly of a wide range of nanostructured materials such as carbon nanotubes, graphite nanoplates, quantum dots, and ...

• MRI Imaging Based on Quantitative Ultrashort Echo Time Imaging of Short T2 Tissues

  Organization: University of California, San Diego (UC San Diego)

  This method uses quantitative imaging techniques to measure magnetic resonance relaxation time. Specifically, the invention combines 2D and 3D, ultrashort, echo time (TE) sequences with appropriate pulses and can be further combined with efficient long T2 suppression pulses to increase the short T2 contrast and reduce long T2 contamination in T2, T2*, T1ρ, and T1 quantification.

• Antibody-based Agents for Imaging in vivo CD8 Expression

  Organization: University of California, Los Angeles (UCLA)

  Researchers in the laboratory of Dr. Anna Wu in the department of Molecular & Medical Pharmacology have developed an antibody-based agent for imaging in vivo CD8 expression in mouse models of disease.  The present invention utilizes the sequencing of the variable domains of anti-mouse-CD8 from hybridomas for the subsequent engineering into antibody fragments, such as, but not limited to, scFv's, diabodies, minibodies and scFv-Fc's.  The antibody is subsequently conjugated to a radioisotope or fluorophore to enable visualization of ...

• NMR Probe for the Detection of Microstructures

  Organization: University of California, Los Angeles (UCLA)

  UCLA researchers developed a NMR probe with sensitivity superior to current designs. It contains a novel noise reduction mechanism, making it the most sensitive probe of its kind. These properties allow the detection of metabolites at the single cell level. Additionally, the probe has a planar configuration, making it ideally suited for microfluidic chips used for diagnosis and prognosis. It is also made with an ultra small detection region, 0.08 mm length by 0.05 mm width by 0.05 mm high, for samples of small volume and low concentration ...

• Improved Cardiac Late Gadolinium Enhancement MRI For Patients With Cardiac Devices

  Organization: University of California, Los Angeles (UCLA)

  Dr. Peng Hu in the Department of Radiological Sciences at UCLA’s David Geffen School ofMedicine has developed an approach to eliminate the image quality distortions associated withpacemakers and ICDs in LGE MRI. The technique has been tested in healthy volunteers and anumber of patients having an implanted ICD.

• Computer-Aided Detection Of Implantable Man-Made Devices In Medical Images

  Organization: University of California, Los Angeles (UCLA)

  Researchers at UCLA have developed a computer-aided detection system (CAD) to detect and assess an IMD for medical imaging. The system is implemented as a computer software package. Following detection and classification of an IMD, the system can automatically generate a detailed report about the images. In detail, a report will include information for automatically determining: (a) location, (b) number, (c) category, manufacturer, and characteristics; (d) comparison to manufacturer's specifications; (e) movement between serial images; ...

• Non-Invasive, Sensitive Diagnostic for Viral Myocarditis

  Organization: University of California, San Diego (UC San Diego)

  Researchers from UC San Diego have identified altered forms of a protein complex present in cardiac muscle (the dystrophin-glyoprotein complex), which is associated with dilated cardiomyopathy caused by enteroviruses. Specifically, the presence of a unique, enteroviral protease 2A-cleavage product provides a highly specific and sensitive biomarker for enteroviral-mediated cleavage of dystrophin.

• High Resolution, Diagnostic Imaging of Fat Composition and Regional Location

  Organization: University of California, San Diego (UC San Diego)

  Commonly employed MRI techniques for separating water and fat exploit differences in the precession frequency of protons in fat and water. UC researchers have simplified and improved analysis and data processing by identifying three most-relevant parameters that can be used to qualitatively and quantitatively image fat. By reducing the complexity of an MRI-generated fat spectrum, one is able to significantly improve the diagnostic utility of a scan with minimal effect on the scan time.

• An Enhanced Powerful Method for Signal Processing in Medical Imaging (MEG, MRI, etc.) and Other Scientific and Engineering Applications (SD2011-252)

  Organization: University of California, San Diego (UC San Diego)

  UC San Diego researchers have developed an enhanced multi-core beam former (eMCBF). The eMCBF detects the orientation (direction) of the signals and allows correlation and reconstruction of multiple interfering sources at the same time. Furthermore, the eMCBF can accurately obtain the individual source time-courses, whereas previous MCBF can only obtain the common mode among multiple source time-courses. Such improvement allows faithful reconstruction of the source temporal dynamics for individual neuronal sources.

• Diagnostic and Therapeutic Particles with Decreased Cavitation Threshold: Payload Released by Focused Ultrasound

  Organization: University of California, San Diego (UC San Diego)

  Inventors at UC San Diego have recently developed compositions of matter, methods of use, and methods of manufacturing vehicles that can be triggered like a microbubble but with the stability of a traditional liposome. This allows them to take advantage of the years of liposome technology with the added benefit of ultrasound triggering. By packaging an acoustically sensitive nanoparticle with specific lipids, the therapeutic payload is stabilized until application of focused ultrasound, which releases the payload only in tissues of ...

• A Novel Method to Increase the Perfusion Signal to Noise Ratio (SNR) in Velocity Selective Arterial Spin Labeling for MRI

  Organization: University of California, San Diego (UC San Diego)

  UC San Diego researchers have developed a VSASL method to address the first property. In conventional VSASL, the tagging of arterial blood is applied once before imaging and the tagged blood undergoes uniform T1 decay prior to image acquisition. If two or more VSS modules are used, some of the recovered tagged blood will be saturated again at a later time. Multiple VSS modules produces tagging that more closely approximates the ideal situation of being continuous. The tagged blood is therefore closer to saturation at the time of ...

• Efficient Method of Mapping Sources of Abnormal Routes of Vascular Circulation Regardless of Their Location Using MRI

  Organization: University of California, San Diego (UC San Diego)

  UC San Diego researchers have developed an efficient method for estimating both the location and resonance offset of all feeding arteries of VEASL from randomly encoded data, allowing for identification of source vessels without prior knowledge of their locations. The method uses unipolar rather than bipolar vessel encoding gradient lobes providing the same encoding functionality, which results in nearly complete insensitivity to resonance offsets at the tagging plane.

• A Restriction Spectrum Imaging Method and Device for Probing Tissue Microstructure

  Organization: University of California, San Diego (UC San Diego)

  UC San Diego researchers have developed an advanced diffusion MRI method, which can be used to probe tissue orientation structures over a range (or "spectrum") of hindered and restricted diffusion length scales with minimal assumptions on the underlying microarchitecture. The invention uses a linear mixture model to relate biological tissue parameters to diffusion MRI signals, which may be collected with various combinations of diffusion gradient strengths, diffusion times, diffusion weighting factors ("b-values"), and diffusion ...

• Three-Dimensional Imaging of Biological Samples

  Organization: Wisconsin Alumni Research Foundation (WARF)

  The ability to analyze the microstructure of biological material in three dimensions is a valuable tool in gaining a clearer understanding of the basic mechanisms of life. When coupled with fluorescence techniques, for example, individual proteins and their interactions can be better visualized. One method to construct three-dimensional images begins by using a custom diamond knife to cut away consecutive thin layers from a block of biological material. These are stained and imaged using a high-sensitivity line-scan camera that repeatedly ...

• PIN Diodes for Fast Photodetection, and High-Speed, High-Resolution Imaging and Sensing

  Organization: Wisconsin Alumni Research Foundation (WARF)

  PIN diodes are semiconductor devices that include an undoped intrinsic semiconductor region between the p-type and n-type regions. These diodes are commonly integrated as photodetectors on silicon CMOS chips for imaging sensing in digital cameras. Silicon CMOS technology offers several advantages, including ease of processing and large-scale integration; however, the speed of silicon-based PIN diodes tends to be slow. Germanium and silicon-germanium (SiGe) alloys offer promising alternative materials for high-quality, CMOS-compatible ...

• Low-Power, Multi-Scale Neural Spike Detector for Analyzing Brain Signals

  Organization: University of Florida

• Novel Algorithm Design to Reduce Radiation Therapy Time and Dosage

  Organization: University of Florida

• Higher Resolution Ultrasonic Imaging Sensor

  Organization: University of Florida

• Multifunctional Nanoparticles as Contrast Agents for Multiple Diagnostic Imaging Techniques and Therapeutic Photo Ablation

  Organization: University of Florida

• Medical Imaging Technology Providing Quantitative Information and Enhanced Resolution

  Organization: University of Florida

• Positron Emission Tomography using [11-11C] N5,N10-methylene-5,6,7,8-tetrahydrofolate

  Organization: University of Iowa Res Foundation

• An Ultrasound-Activated MRI Contrast Agent and Drug Delivery System

  Organization: Children's Hospital Los Angeles

• Ultra Videoconferencing

  Organization: McGill University

  One of the most advanced validated videoconferencing systems available today: flexible, extremely low-latency IP transport system for audio, video, and most recently, vibrosensory data. The application has been used in a range of demanding applications including live concert streaming (1999), remote audio mixing (2000), collaborative performance (2001), distance masters classes over SDI (2002), and remote video interpreting of sign language using three simultaneous DV streams (2003) and won the SuperComputing 2005 conference award for "Most ...

• Computer-Aided Diagnosis Software for Neurological Diseases

  Organization: McGill University

  McGill researchers have developed a completely automated software tool for the classification and early detection of neurological diseases. The invention consists in software for the analysis of large, non-specific areas from anatomical magnetic resonance images of patients to classify according to disease state. Based on no a priori assumptions, the underlying method escapes the pitfalls of the segmentation paradigm common to other detection approaches. This technique has potential applications in the area of localization of seizure focus ...

• MASDA (Multi-Element-Amorphous-Silicon-Detector-Array) Real-Time Imager & Dosimeter for Mega-Voltage Photons

  Organization: University of Michigan

• A Method for Polarization and Delivery of Polarized 129Xe Gas for Magnetic Resonance Imaging

  Organization: University of Michigan

  Background Medical imaging methods including MRI (Magnetic Resonance Imaging) and CAT (Computed Axial Tomography) are used to study the internal structure and operation of organs. MRI, in particular, is a predominant means of noninvasively studying internal systems employing large magnetic fields to align/polarize atoms within a sample. Radio frequency fields are used to change the alignment, which can be detected and used to construct images. This method is very robust but in systems with a low-density of atoms, such as the lungs, the signal ...

• Optical Fiberless Sensors

  Organization: University of Michigan