Tunable Contrast Agents for Biomarker-Specific Ultrasound Imaging
Organization: University of California, San Diego (UC San Diego)
Disclosed are “smart” contrast agents that enhance ultrasound signal in a specific chemical environment through modulation of harmonic signals. The invention’s agents are comprised of microbubbles with tunable contrast activity based on the stiffness of their encapsulating shell. In the invention, the stiffness is controlled by a network of crosslinkable DNA on the microbubble’s shell. One DNA sequence is appended to the microbubble shell covalently, which allows free oscillatory movement of the lipid membrane ...
Apolipoprotein Imaging Contrast Agent
Organization: University of California, Davis (UC Davis)
Researchers at the University of California, Davis, have developed a contrast agent allowing for the quantitative assessment of real time magnetic resonance images of high density lipoprotein (HDL) and apolipoprotein A1 (Apo-A1), which yields an index to diagnose, prognose and evaluate a host of diseases (e.g., cardiovasculature impairment, diabetes, obesity, kidney dysfunction). Linking a Gd-methanethiosulfonate to a single cysteine variant of Apo-A1 produces a targeted magnetic resonance imaging (MRI) agent for HDL and Apo-A1 ...
Organization: Stanford University
Simple aqueous fluorination of PET imaging agents
Organization: Stanford University
Organization: Stanford University
A GI-Specific Contrast Agent for Magnetic Resonance Imaging
Organization: University of Arizona
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Tunable Contrast Agents for Biomarker-Specific Ultrasound Imaging
Organization: Indiana Univ-Purdue University Indianapolis
Disclosed are “smart” contrast agents that enhance ultrasound signal in a specific chemical environment through modulation of harmonic signals. The invention’s agents are comprised of microbubbles with tunable contrast activity based on the stiffness of their encapsulating shell. In the invention, the stiffness is controlled by a network of crosslinkable DNA on the microbubble’s shell. One DNA sequence is appended to the microbubble shell covalently, which allows free oscillatory movement of the lipid membrane ...
Smart Materials Capable of Programmed Shape Change
Organization: Indiana Univ-Purdue University Indianapolis
UC San Diego researchers have developed soft nanoparticle materials that exhibit reversible, stimuli-responsive changes in morphology. In its primary embodiment, the invention leverages the utility of DNA as an informational molecule to design nanoparticles that undergo reversible morphological changes in a DNA-encoded fashion. Utilizing the sequence selective recognition properties of DNA, and its performance as a substrate for selective enzymatic cleavage, the amphiphilicity of a range of surfactants is programmed and tuned. This approach ...
Organization: Indiana Univ-Purdue University Indianapolis
Renal Clearing Iron Oxide Nanoparticles for Tumor Integrin Targeting
Organization: Indiana Univ-Purdue University Indianapolis
Organization: Stanford University
Simple aqueous fluorination of PET imaging agents
Organization: Stanford University
Organization: Stanford University
Biocompatible Nanostructures For Ultrasensitive Biomolecular Sensors And Cellular Imaging
Organization: University of California, Berkeley (UC Berkeley)
Smart Materials Capable of Programmed Shape Change
Organization: University of California, San Diego (UC San Diego)
UC San Diego researchers have developed soft nanoparticle materials that exhibit reversible, stimuli-responsive changes in morphology. In its primary embodiment, the invention leverages the utility of DNA as an informational molecule to design nanoparticles that undergo reversible morphological changes in a DNA-encoded fashion. Utilizing the sequence selective recognition properties of DNA, and its performance as a substrate for selective enzymatic cleavage, the amphiphilicity of a range of surfactants is programmed and tuned. This approach ...
Contrast Agents That Improve GI Tract Opacification During Abdominal and Pelvic CT Scans
Organization: Wisconsin Alumni Research Foundation (WARF)
Computed tomography (CT) uses special X-ray equipment to obtain image data from different angles of the body and generate a cross-sectional image of body tissues and organs. Because CT is a non-invasive procedure that provides detailed, cross-sectional images of all types of tissue, it is a preferred method for diagnosing diseases of the bowel and colon. Water or a positive, liquid contrast agent is often administered to help the radiologist better visualize the stomach, small bowel, and colon; however, these agents may not adequately ...
Synthesis of Magnetic Resonance Imaging Contrast Agents Using Ring-Opening Metathesis Polymerization
Organization: Wisconsin Alumni Research Foundation (WARF)
Magnetic resonance imaging (MRI) is a powerful diagnostic method in which three-dimensional images of body tissues are obtained. Contrast agents are administered prior to imaging to enhance specific features of an image, improving the sensitivity and utility of MRI. Hydroxypyridonate (HOPO)-based gadolinium ion chelates are more effective at enhancing contrast in MRI images than other contrast agents. UW-Madison researchers have developed sensitive and versatile polymer-based contrast agents for MRI. The contrast agents were synthesized ...
Fullerene-Based Contrast Agent for X-Ray Imaging
Organization: Rice University
Flexible and Cost Effective Contrast Agent Enhanced Preclinical MRI
Organization: WORLDiscoveries - University of Western Ontario
An Ultrasound-Activated MRI Contrast Agent and Drug Delivery System
Organization: Children's Hospital Los Angeles
