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Details |
| Project Title | Cell Lines for High Throughput Screening of Estrogenic Compounds | |
|---|---|---|
| Track Code | P150257US01 | |
| Website | http://www.warf.org/technologies/summary/P150257US01.cmsx | |
| Short Description | Two estrogen receptor isoforms regulate normal mammary cells in response to estrogen: ERα and ERβ. ERα is currently a therapeutic target in breast cancer, and breast cancers expressing ERα are commonly treated with ERα antagonists including tamoxifen and raloxifene. It is estimated that 50 to 60 percent of triple negative breast cancers express ERβ and it may also prove to be an effective therapeutic target. A UW–Madison researcher has developed cells lines, Hs578T-ERαLuc and Hs578T-ERβLuc, with stable estrogen receptor elements fused to luciferase genes as well as separate inducible estrogen receptor (ER) constructs. Inducible ER expression will allow the use of high throughput screening for identifying ER-selective ligands inside cells. | |
| Abstract | The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing cell lines for screening and characterization of the estrogen receptor specificity of compounds. | |
| Tags | biotechnology, Cell Line, estrogen receptor, breast cancer | |
| Posted Date | Jul 26, 2017 9:22 PM | |
Advantages |
- Biomaterial readily available for licensing
- Valuable tools for identifying compounds that show selectivity for ERα and ERβ given their sensitivity, selectivity and stability
Potential Applications |
- These cell lines provide a high throughput format to screen for compounds that selectively activate either ERα or ERβ.
Additional Information |
Contact Information |
TTO Home Page: http://www.warf.org
Name : Jennifer Gottwald
Title : Director of Licensing
Department : Licensing
Email : jennifer@warf.org
Phone : 608-960-9854
Address : 614 Walnut Street, 13th floor, Madison, WI 53726
Principal Investigator |
Name : Frank Secreto
Department : Mayo Foundation for Medical Education and Research
Name : John Hawse
Department : Mayo Foundation for Medical Education and Research
Name : Wei Xu
Department : Oncology
Intellectual Property |