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| Project Title | Nanowire-Coated Planar Microdevices For Transmucosal Drug Delivery | |
|---|---|---|
| Track Code | 28794 | |
| Website | https://techtransfer.universityofcalifornia.edu/NCD/28794.html?utm_source=AUTMGTP&utm_medium=webpage&utm_term=ncdid_28794&utm_campaign=TechWebsites | |
| Short Description | The device enhances oral drug delivery because of the following: (1) it binds to the lining of the gastrointestinal tract, thereby providing proximal drug release and prolonged drug exposure, addressing issues of solubility; (2) the planar shape of these devices coupled with their adhesive properties will allow for unidirectional drug release toward epithelial tissue, addressing issues of drug permeation; (3) the drug loaded onto the devices will be released in a sustained manner, decreasing exposure to harsh conditions of the gastrointestinal tract, thereby reducing drug degradation. | |
| Abstract | This invention describes a first-of-a-kind methodology using micro- and nanofabrication techniques to create polymeric microscale devices that are asymmetrically coated with nanowires. The nanowire coating provides an inherent high-throughput, low-waste drug loading mechanism, enhanced cytoadhesion, and may potentially interact with epithelial tissue to enhance drug permeation. | |
| Tags | Nanotechnology, Nanomaterials, Oral drug delivery, microdevice, Delivery Systems, NanoBio | |
| Posted Date | Jul 22, 2017 7:52 AM | |
Advantages |
Oral drug administration is the preferred route due to its low cost, ease of use, and high patient compliance. However, many therapeutics have low oral uptake, thereby requiring other routes of administration (e.g. intravenous injections), which can be less ideal. The major barriers to oral drug delivery are drug solubility, drug permeability, and drug degradation. This invention is meant to address all three barriers. The nanowire-coated microdevices are expected to enhance oral uptake of a wide range of drugs that currently have low oral bioavailabilities.
Potential Applications |
Additional Information |
Stage of Development
Pre-clinical
Looking for Partners
To develop & commercialize the technology as an oral drug delivery system.
Data Availability
Under CDA / NDA
Related Materials
Additional Technologies by these Inventors
- Sealed Nanostraw Microdevices For Oral Drug Delivery
- PRO- RESOLVING MEDIATORS AND DEVICES FOR THERAPEUTIC MODULATION OF BLOOD VESSEL HEALING
Tech ID/UC Case
28794/2015-082-0
Related Cases
2015-082-0
Contact Information |
Principal Investigator |
Name : Tejal Desai
Department :
Name : Hariharasudhan Chirra Dinakar
Department :
Name : Cade Fox
Department :
Intellectual Property |