Details |
Project Title | Growth Factor Regulation in Blood Products for Improved Wound Healing | |
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Track Code | P160179US01 | |
Website | http://www.warf.org/technologies/summary/P160179US01.cmsx | |
Short Description | Growth factor regulation is a key function of the extracellular matrix and critical for proper blood vessel growth and maturation during wound healing. In particular, blood vessel sprouting is essential for effective healing and dependent on the well-regulated activity of vascular endothelial growth factor (VEGF). Research has shown that blood vessel sprouting can only occur within a limited VEGF concentration range in vivo. The need to maintain VEGF activity within a particular concentration range during angiogenesis has motivated the search for therapeutic interventions when natural regulation is dysfunctional, such as during diabetic wound healing and tumor growth. Unregulated VEGF activity can result in hemangioma formation and is linked to poor musculoskeletal wound healing, ocular disease and other health concerns.\r\n\r\nUW–Madison researchers have developed hydrogel microspheres for sequestering problematic growth factors, specifically VEGF, in patient-derived blood products. The degradable microspheres are functionalized with peptide ligands that selectively bind and remove unwanted VEGF from platelet rich plasma and other blood products before they are used in clinical procedures. | |
Abstract | The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing hydrogel microspheres that selectively remove VEGF from blood products prior to clinical use. | |
Tags | medical, vegf, wound healing | |
Posted Date | Jul 20, 2017 9:24 PM |
Advantages |
- Lower cost and more convenient that existing antibody-based approaches
- Enables intraoperative processing of blood products prior to clinical use
Potential Applications |
- Medical device for the purification of autologous blood products and/or clinical delivery of products that have been selectively altered
- Common uses of platelet-derived growth factors include wound healing and recovery from sports-related injuries.
Additional Information |
Contact Information |
TTO Home Page: http://www.warf.org
Name : Rafael Diaz
Title : Licensing Manager
Department : Licensing
Email : rdiaz@warf.org
Phone : 608-960-9847
Address : 614 Walnut Street, 13th floor, Madison, WI 53726
Principal Investigator |
Name : Connie Chamberlain
Department : Orthopedics and Rehabilitation Medicine
Name : David Belair
Department : Biomedical Engineering
Name : Michael Toepke
Department : Biomedical Engineering
Name : Ngoc Nhi T. Le
Department : Materials Science Program
Name : Nicholas Impellitteri
Department : Biomedical Engineering
Name : William Murphy
Department : Biomedical Engineering
Intellectual Property |
Patent Number : 10,183,079
Patent Title : HYDROGEL MICROSPHERES CONTAINING PEPTIDE LIGANDS FOR GROWTH FACTOR REGULATION IN BLOOD PRODUCTS
Patent Application Date : Mar 18, 2016
Patent Publication Date : Sep 21, 2017
Patent Issue Date : Jan 22, 2019
Patent Link : http://www.warf.org/documents/ipstatus/P160179US01.PDF