Details

Project TitleGrowth Factor Regulation in Blood Products for Improved Wound Healing
Track CodeP160179US01
Websitehttp://www.warf.org/technologies/summary/P160179US01.cmsx
Short DescriptionGrowth factor regulation is a key function of the extracellular matrix and critical for proper blood vessel growth and maturation during wound healing. In particular, blood vessel sprouting is essential for effective healing and dependent on the well-regulated activity of vascular endothelial growth factor (VEGF). Research has shown that blood vessel sprouting can only occur within a limited VEGF concentration range in vivo.

The need to maintain VEGF activity within a particular concentration range during angiogenesis has motivated the search for therapeutic interventions when natural regulation is dysfunctional, such as during diabetic wound healing and tumor growth. Unregulated VEGF activity can result in hemangioma formation and is linked to poor musculoskeletal wound healing, ocular disease and other health concerns.\r\n\r\nUW–Madison researchers have developed hydrogel microspheres for sequestering problematic growth factors, specifically VEGF, in patient-derived blood products. The degradable microspheres are functionalized with peptide ligands that selectively bind and remove unwanted VEGF from platelet rich plasma and other blood products before they are used in clinical procedures.
AbstractThe Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing hydrogel microspheres that selectively remove VEGF from blood products prior to clinical use.
 
Tagsmedical, vegf, wound healing
 
Posted DateJul 20, 2017 9:24 PM

Advantages

  • Lower cost and more convenient that existing antibody-based approaches
  • Enables intraoperative processing of blood products prior to clinical use

Potential Applications

  • Medical device for the purification of autologous blood products and/or clinical delivery of products that have been selectively altered
  • Common uses of platelet-derived growth factors include wound healing and recovery from sports-related injuries.

Additional Information

Contact Information

TTO Home Page: http://www.warf.org



Name : Rafael Diaz

Title : Licensing Manager

Department : Licensing

Email : rdiaz@warf.org

Phone : 608-960-9847

Address : 614 Walnut Street, 13th floor, Madison, WI 53726

Principal Investigator

Name : Connie Chamberlain

Department : Orthopedics and Rehabilitation Medicine



Name : David Belair

Department : Biomedical Engineering



Name : Michael Toepke

Department : Biomedical Engineering



Name : Ngoc Nhi T. Le

Department : Materials Science Program



Name : Nicholas Impellitteri

Department : Biomedical Engineering



Name : William Murphy

Department : Biomedical Engineering

Intellectual Property

Patent Number : 10,183,079

Patent Title : HYDROGEL MICROSPHERES CONTAINING PEPTIDE LIGANDS FOR GROWTH FACTOR REGULATION IN BLOOD PRODUCTS

Patent Application Date : Mar 18, 2016

Patent Publication Date : Sep 21, 2017

Patent Issue Date : Jan 22, 2019

Patent Link : http://www.warf.org/documents/ipstatus/P160179US01.PDF