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Details |
| Project Title | Rhinovirus-C Peptide for Development of Vaccines and Antivirals | |
|---|---|---|
| Track Code | P160341US02 | |
| Website | http://www.warf.org/technologies/summary/P160341US02.cmsx | |
| Short Description | Human rhinoviruses (species A, B and C) are responsible for the majority of upper respiratory tract infections (like the common cold) and many infections of the lower respiratory tract as well. Rhinovirus C species (RV-C) was discovered in 2006 and is of special interest because it can cause more severe illnesses in children and is closely associated with asthma exacerbations. However, no vaccines or effective antiviral treatments for RV-C currently are available.\r\n\r\nUW–Madison researchers have identified novel immunogenic peptides from RV-C that are useful targets for therapeutic antibodies. Recent advances in microscopy enabled the researchers to determine (with atomic resolution) the structure of an RV-C strain, both in its full, infectious form and as native empty particles. The structures highlighted immunogenic surfaces that could be used to design antivirals or vaccines against RV-C. | |
| Abstract | The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing an immunogenic peptide from rhinovirus-C, as well as related vaccines and therapeutic compounds. | |
| Tags | biotechnology, Drug Discovery, rhinovirus C | |
| Posted Date | Jul 19, 2017 9:24 PM | |
Advantages |
Potential Applications |
- Prevention and treatment of RV-C infection, including infection associated with childhood asthma and adult respiratory problems
Additional Information |
P140382US02 describes an efficient, cost-effective method of propagating RV-C.
http://www.warf.org/technologies/summary/P140382US02.cmsx
Liu Y., Hill M.G., Klose T., Chen Z., Watters K., Bochkov Y.A., Jiang W., Palmenberg A.C. and Rossmann M.G. 2016. Atomic Structure of a Rhinovirus C, a Virus Species Linked to Severe Childhood Asthma. Proc. Natl. Acad. Sci. USA. 113, 8997-9002.
Liu Y., Hill M.G., Klose T., Chen Z., Watters K., Bochkov Y.A., Jiang W., Palmenberg A.C. and Rossmann M.G. 2016. Atomic Structure of a Rhinovirus C, a Virus Species Linked to Severe Childhood Asthma. Proc. Natl. Acad. Sci. USA. 113, 8997-9002.
P160050US02 features a mutated RV-C strain that achieves maximum replication, virus yields and cytopathic effect in HeLa-E8 cells.
Contact Information |
TTO Home Page: http://www.warf.org
Name : Jennifer Gottwald
Title : Director of Licensing
Department : Licensing
Email : jennifer@warf.org
Phone : 608-960-9854
Address : 614 Walnut Street, 13th floor, Madison, WI 53726
Principal Investigator |
Name : Ann Palmenberg
Department : Institute for Molecular Virology
Name : Kelly Watters
Department : Institute for Molecular Virology
Name : Marchel Hill
Department : Institute for Molecular Virology
Name : Michael Rossman
Department : Purdue University
Name : Yue Liu
Department : Purdue University
Intellectual Property |
Patent Number : 10,428,116
Patent Title : RHINOVIRUS C IMMUNOGENIC PEPTIDES
Patent Application Date : Apr 19, 2017
Patent Publication Date : Oct 26, 2017
Patent Issue Date : Oct 1, 2019
Patent Link : http://www.warf.org/documents/ipstatus/P160341US02.PDF