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| Project Title | Analogs of Diptoindonesin G for Breast Cancer Drug Development | |
|---|---|---|
| Track Code | P170010US02 | |
| Website | http://www.warf.org/technologies/summary/P170010US02.cmsx | |
| Short Description | The natural product diptoindonesin G (Dip G) was first isolated in 2009 from the tree bark of Hopea mengarawan. It has shown antiproliferation effects in murine leukemia as well as immunosuppressant activity. Recently, it was reported to promote degradation of estrogen receptor alpha (ERα) while stabilizing ERβ, a tumor suppressor in breast cancer. Importantly, Dip G, by taking a different mechanism from the existing Selective Estrogen Receptor Degrader (SERDs), significantly decreases ERα mutant protein levels found in recurrent, metastatic breast cancer.\r\n\r\nUW–Madison researchers have synthesized analogs of Dip G that have shown a greater ability than the parent molecule to decrease ERα expression and stabilize ERβ in cultured breast cancer cells. The compounds are active for ameliorating, attenuating and halting the growth/metastasis of breast cancers. | |
| Abstract | The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a novel set of compounds that have been shown to inhibit tumor growth in animal studies. | |
| Tags | None | |
| Posted Date | Jun 27, 2017 9:23 PM | |
Advantages |
- Promising toxicity and efficacy data
- Provides a drug development opportunity in surging market space
- Innovative licensing and/or development terms may be available.
Potential Applications |
- Novel compounds for development into breast cancer pharmaceuticals
- Novel compounds for development in treating endocrine resistant breast cancer harboring ERα mutations
Additional Information |
Contact Information |
TTO Home Page: http://www.warf.org
Name : Rafael Diaz
Title : Licensing Manager
Department : Licensing
Email : rdiaz@warf.org
Phone : 608-960-9847
Address : 614 Walnut Street, 13th floor, Madison, WI 53726
Principal Investigator |
Name : Jill Kolesar
Department : Pharmaceutical Sciences
Name : Jitian Liu
Department : Pharmaceutical Sciences
Name : Wei Xu
Department : Oncology
Name : Weiping Tang
Department : Pharmaceutical Sciences
Intellectual Property |
Patent Number : 10,508,092
Patent Title : SYNTHESIS OF NOVEL ANALOGS OF DIPTOINDONESIN G, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Patent Application Date : Aug 29, 2017
Patent Publication Date : Mar 8, 2018
Patent Issue Date : Dec 17, 2019
Patent Link : http://www.warf.org/documents/ipstatus/P170010US02.PDF