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| Project Title | Bioreversible Boronates Improve Drug Delivery | |
|---|---|---|
| Track Code | P150009US02 | |
| Website | http://www.warf.org/technologies/summary/P150009US02.cmsx | |
| Short Description | The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents and the negatively charged cell surface. Other efforts have focused on natural ligands to target and bind agents to specific receptors on the cell surface. Such methods have been used to deliver pharmaceuticals, proteins, peptides, nucleic acids and other particles into cells. While this has yielded some success, there remains a need for additional delivery strategies. In particular, the ability to bioreversibly modify molecules (i.e., enhance cellular uptake without effecting stability, function or immunogenicity) is highly desirable.\r\n\r\nA UW–Madison researcher has developed methods and reagents for enhancing cellular uptake in vivo or in vitro by attaching to any desired molecule one or more phenylboronic acid groups. The method is bioreversible; the boronate compound is cleaved from the molecule by intracellular enzymes, leaving its ‘cargo’ unaltered. Advantageously, boronic acids readily form esters within the dense forest of polysaccharides, known as the glycocalyx, found on the surface of many cells. Targeting therapeutic agents to the glycocalyx has been shown to enhance cellular delivery. In addition, boronate groups are compatible with human physiology, appearing in chemotherapeutic agents and other remedies. | |
| Abstract | The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing improved methods of boronating cargo molecules to enhance their uptake in cells. | |
| Tags | biotechnology, pharmaceutical, Drug delivery | |
| Posted Date | Jun 8, 2017 9:25 PM | |
Advantages |
- Bioreversible
- Demonstrated to enhance cellular uptake
- Delivery can take place in vivo or in vitro.
Potential Applications |
Additional Information |
Andersen K.A., Smith T.P. and Raines R.T. 2016. Boronic Acid for the Traceless Delivery of Proteins into Cells. ACS Chem. Biol. 11, 319-323.
Andersen K.A., Smith T.P. and Raines R.T. 2016. Boronic Acid for the Traceless Delivery of Proteins into Cells. ACS Chem. Biol. 11, 319-323.
WARF reference number P150031US02 describes the researcher’s bioreversible method of fluorenylating proteins and drugs to enhance their uptake in cells.
Contact Information |
TTO Home Page: http://www.warf.org
Name : Jennifer Gottwald
Title : Director of Licensing
Department : Licensing
Email : jennifer@warf.org
Phone : 608-960-9854
Address : 614 Walnut Street, 13th floor, Madison, WI 53726
Principal Investigator |
Intellectual Property |
Patent Number : 9,732,101
Patent Title : BIOREVERSIBLE BORONATES FOR DELIVERY OF MOLECULES INTO CELLS
Patent Application Date : Jul 27, 2015
Patent Publication Date : Jan 28, 2016
Patent Issue Date : Aug 15, 2017
Patent Link : http://www.warf.org/documents/ipstatus/P150009US02.PDF