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Details |
| Project Title | Natural Antibiotic to Treat Clostridium Infection and More | |
|---|---|---|
| Track Code | P140428US02 | |
| Website | http://www.warf.org/technologies/summary/P140428US02.cmsx | |
| Short Description | Bacterial resistance to antibiotics is an escalating problem, especially in hospital settings. The Centers for Disease Control recently identified Clostridium difficile as posing an “urgent” health threat, highlighting the need for new and effective therapeutics. C. difficile is the most common cause of nosocomial infectious diarrhea. The bacteria sicken half a million people each year and 20 percent of patients get sick again following treatment.\r\n\r\nUW–Madison researchers have identified a potential new antibiotic to treat infections caused by C. difficile, Staphylococcus and other drug-resistant strains. The compound is a natural product called ecteinamycin. It was discovered and isolated from a sea squirt bacterium (Actinomadura). Preliminary data suggests ecteinamycin is potent, selective and able to protect cells against bacterial toxins. | |
| Abstract | The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing ecteinamycin, a compound that may be more potent than drugs currently used to treat serious bacterial infections. | |
| Tags | pharmaceutical, antibiotic, natural product | |
| Posted Date | Jun 8, 2017 9:25 PM | |
Advantages |
- Potential new weapon against dangerous and drug-resistant bacteria
- May be superior to available antibiotics
Potential Applications |
- Novel antibiotic to fight Gram-positive/negative bacteria, including C. difficile, methicillin-resistant S. aureus and vancomycin-resistant Enterococcus
Additional Information |
WARF reference number P130274US02 describes compounds isolated from the sea squirt bacterium that may be effective against fungal infections.
Contact Information |
TTO Home Page: http://www.warf.org
Name : Rafael Diaz
Title : Licensing Manager
Department : Licensing
Email : rdiaz@warf.org
Phone : 608-960-9847
Address : 614 Walnut Street, 13th floor, Madison, WI 53726
Principal Investigator |
Name : Douglas Braun
Department : Pharmaceutical Sciences
Name : Jeff Piotrowski
Department : Great Lakes Bioenergy Research Center
Name : Nasia Safdar
Department : Medicine
Name : Thomas Wyche
Department : Pharmaceutical Sciences
Name : Timothy Bugni
Department : Pharmaceutical Sciences
Intellectual Property |
Patent Number : 10,660,874
Patent Title : ECTEINAMYCIN, COMPOSITIONS AND USES THEREOF
Patent Application Date : Oct 28, 2015
Patent Publication Date : Dec 7, 2017
Patent Issue Date : May 26, 2020
Patent Link : http://www.warf.org/documents/ipstatus/P140428US02.PDF