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Ultra-Stable Printing using Aqueous Complex Coacervates
PRODUCT OPPORTUNITIES
- Green printing
- Encapsulation, delivery, remediation, and sensing in food and personal care industries
… more
PRODUCT OPPORTUNITIES
- Green printing
- Encapsulation, delivery, remediation, and sensing in food and personal care industries, for drug and gene delivery, and as underwater adhesives
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
- Purely aqueous processing without the need for any organic solvents
- Printed coacervate materials are robust when exposed to solvents and elevated temperature (stable up to 450℃)
TECHNOLOGY DESCRIPTION
This invention provides a cost effective and environmentally friendly printing method with an “ink” that is based on a class of polymer-rich liquids, termed complex coacervates. The fully aqueous nature of coacervate-based materials avoids the need for purification or post-processing to remove toxic organic solvents and enables technology for much desired green printing. The low surface tension of coacervates with water has also facilitated their use as encapsulants in the food and personal care industries, for drug and gene delivery, ad as under water adhesives.
ABOUT THE INVENTOR
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- Prof. Jessica Schiffman is a professor in the Department of Chemical Engineering at the University of Massachusetts Amherst. Her research interests lie in The Schiffman laboratory is an interdisciplinary and imaginative research team that uses “greener” materials science and engineering to address grand challenges in human health.
- Prof. Sarah Perry is an Associate Professor in the Chemical Engineering department at University of Massachusetts Amherst. Her research interests include utilizing self-assembly, molecular design, and microfluidic technologies to generate biologically relevant microenvironment for the study and application of biomacromolecules.
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 17-052
PATENT STATUS:
- Patent Issued US10767060B2
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR:
Jessica Schiffman, Ph.D., and Sarah Perry Ph.D.
CONTACT:
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- This invention provides a cost effective and environmentally friendly printing method with an “ink” that is based on a class of polymer-rich liquids, termed complex coacervates. The fully aqueous nature of coacervate-based materials avoids the need for purification or post-processing to remove toxic organic solvents and enables technology for much desired green printing. The low surface tension of coacervates with water has also facilitated their use as encapsulants in the food and personal care industries, for drug and gene delivery, ad as under water adhesives.
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Primary:
University of Massachusetts Amherst
Date posted:
Mar 19, 2024
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Microfluidic Devices with Graphene Electrodes
PRODUCT OPPORTUNITIES
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- Microfluidic platform for use in electro-crystallization and electro-crystallography experiments
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES … more
PRODUCT OPPORTUNITIES
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- Microfluidic platform for use in electro-crystallization and electro-crystallography experiments
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
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- Use of graphene as X-ray compatible electrodes enables the application of electric fields on-chip during X-ray analysis, which can be used to modulate structure of protein or other molecules in crystalline (for X-ray diffraction) or solution form (for X-ray scattering)
- Lifetime of fragile samples can be extended by expediting the removal of reactive secondary
TECHNOLOGY DESCRIPTION
This invention describe the manufacturing and use of a novel microfluidic platform for use in electro-crystallization experiments. The device incorporates ultra-thin graphene-based films as electrodes as X-ray transparent windows to enable in situ X-ray diffraction analysis.
ABOUT THE INVENTOR
Prof. Sarah Perry is an Associate Professor in the Chemical Engineering department at University of Massachusetts Amherst. Her research interests include utilizing self-assembly, molecular design, and microfluidic technologies to generate biologically relevant microenvironment for the study and application of biomacromolecules.
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 18-080
PATENT STATUS:
- Patent Issued US 11,175,244 B2
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR:
CONTACT:
This invention describe the manufacturing and use of a novel microfluidic platform for use in electro-crystallization experiments. The device incorporates ultra-thin graphene-based films as electrodes as X-ray transparent windows to enable in situ X-ray diffraction analysis.
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Primary:
University of Massachusetts Amherst
Date posted:
Mar 2, 2024
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Flow Sensor Based on Coulometric Interrogation of a Graphene Microelectrode
PRODUCT OPPORTUNITIES
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- Self-powered, high-performance biofluid-flow interrogation devices (e.g., minimally-invasive implantable blood flow monitor, miniaturized flow sensor
… more
PRODUCT OPPORTUNITIES
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- Self-powered, high-performance biofluid-flow interrogation devices (e.g., minimally-invasive implantable blood flow monitor, miniaturized flow sensor, transparent flow sensor)
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
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- Significantly improved sensitivity (two-orders-of-magnitude improvement) paves ways for life phenomena that are yet to be studied in metabolomics, retinal hemorheology, and neuroscience
- Long-term stability (over 6 months demonstrated)
TECHNOLOGY DESCRIPTION
This invention demonstrates a nanodevice that employs a single microelectrode of monolayer graphene to monitor biofluid-flow in real time at high resolution and stability
ABOUT THE INVENTOR
Prof. Jinglei Ping is a professor in the Department of Mechanical and Industrial Engineering at the University of Massachusetts Amherst. His research interest includes biosensing devices based on 2D materials and translation of 2D materials into point-of-care diagnostics, drug testing, and healthcare applications.
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 20-028
PATENT STATUS:
Patent Pending
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR:
CONTACT:
This invention demonstrates a nanodevice that employs a single microelectrode of monolayer graphene to monitor biofluid-flow in real time at high resolution and stability
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Primary:
University of Massachusetts Amherst
Date posted:
Mar 1, 2024
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Localization of Payload Delivery Systems to Tumor Sites via Beacon Cell Targeting
PRODUCT OPPORTUNITIES
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- Safe and efficacious delivery of payload to a tumor
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
… morePRODUCT OPPORTUNITIES
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- Safe and efficacious delivery of payload to a tumor
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
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- Provides possibility to deliver potentially toxic therapy/molecule to bacteria-associated tumors with significantly reduced off-target accumulation while increasing tumor localization, efficacy, and tumor transport.
- Broadens scope of targetable cancers
TECHNOLOGY DESCRIPTION
This invention overcomes the low therapeutic efficacy and transportation of the payload into the tumor by utilizing noncancerous cells in tumors as beacons for targeted delivery of therapeutic payloads. This results in significantly enhanced accumulation, transport, and penetration of a given payload in tumor tissue, thereby diminishing side effects and improving efficacy and safety.
ABOUT THE INVENTOR
- Prof. Neil Forbes is a professor in the Chemical Engineering department at the University of Massachusetts Amherst, whose research interest is at the interface of engineering and medicine, with the focus on bacterial therapies for cancer treatment.
- Prof. John Klier was a professor and department head of Chemical Engineering department at the University of Massachusetts Amherst for 5 years before joining the University of Oklahoma as Dean of the Gollogly College of Engineering and professor in the School of Chemical, Biological and Materials Engineering. He is a member of the National Academy of Engineering and National Academy of Inventors.
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 19-033
PATENT STATUS:
Patent Pending
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR:
- John Klier, Ph.D., Neil Forbes, Ph.D.
CONTACT:
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- This invention overcomes the low therapeutic efficacy and transportation of the payload into the tumor by utilizing noncancerous cells in tumors as beacons for targeted delivery of therapeutic payloads. This results in significantly enhanced accumulation, transport, and penetration of a given payload in tumor tissue, thereby diminishing side effects and improving efficacy and safety.
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Primary:
University of Massachusetts Amherst
Date posted:
Feb 29, 2024
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Antibody for Treatment and Diagnosis of Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT)
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Applications include:
- Use in the diagnosis and study of VITT, through the
… more
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Applications include:
- Use in the diagnosis and study of VITT, through the detection and measurement of the antibodies; and
- Clinical applications as a treatment method for patients with VITT and potentially heparin-induced thrombocytopenia (HIT).
Advantages include:
- First VITT anti-PF4 antibody to be introduced for this disorder; and
- Discovery can be used in understanding VITT pathology, diagnosis, and potential treatments.
APPLICATIONSTECHNOLOGY DESCRIPTION Vaccine-induced immune thrombotic thrombocytopenia (VITT), causing blood clotting and low platelet counts, has been identified as a reaction to the COVID-19 adenoviral (Ad) vectored vaccines [1]. To allow for sufficient diagnosis and treatment, it is important to elucidate the mechanism of VITT [1].
Researchers at McMaster University and University of Massachusetts Amherst have determined the polypeptide sequence of the variable region for unique anti-platelet factor 4 (PF4) antibodies, which is implicated in VITT [2].
References:
1. Roytenberg, R., García-Sastre, A. & Li, W. Vaccine-induced immune thrombotic thrombocytopenia: what do we know hitherto? Frontiers in Medicine 10, (2023).
2. Nguyen, S. N. et al. Structural characterization of a pathogenic antibody underlying vaccine-induced immune thrombotic thrombocytopenia (VITT). bioRxiv 2023.05.28.542636 (2023) doi:10.1101/2023.05.28.542636.
Image obtained from: https://www.istockphoto.com
ABOUT THE INVENTOR
Dr. Igor Kaltashov is a professor of Chemistry at UMass Amherst where he and his research team are focused on developing novel analytical strategies to study biopolymer architecture, dynamics, and function using mass spectrometry and chromatography as primary research tools.
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 23-031
PATENT STATUS:
US Provisional filed
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR FOR UMASS:
Dr. Igor Kaltashov
CONTACT:
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Primary:
University of Massachusetts Amherst
Date posted:
Feb 15, 2024
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Katsumata / Vinyl-Comonomer Additive for Radically Activated Dynamic Phenomena
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Recycling thermoplastics and thermosets
APPLICATIONSTECHNOLOGY DESCRIPTION
This invention demonstrates the synthesis of … more
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Recycling thermoplastics and thermosets
APPLICATIONSTECHNOLOGY DESCRIPTION
This invention demonstrates the synthesis of cyclic allyl sulfide small molecule that incorporates into acrylates and styrenic polymer and fosters robust reprocess-ability through radically initiated scission and extension.
ABOUT THE INVENTOR
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- Dr. Reika Katsumata is an Assistant Professor in the Department of Polymer Science and Engineering at the UMass Amherst. Her research interests include design extremely confided soft/hard interfaces.
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 23-060
PATENT STATUS:
Patent Pending
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR:
Reika Katsumata
CONTACT:
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Primary:
University of Massachusetts Amherst
Date posted:
Feb 9, 2024
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McLandsborough / Stable water-in-oil antimicrobial concentrate
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Antimicrobial concentrate to mix-in with carrier oil for cleaning low-moisture food processing … more
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Antimicrobial concentrate to mix-in with carrier oil for cleaning low-moisture food processing environment
APPLICATIONSTECHNOLOGY DESCRIPTION
This invention provides a novel and straightforward antimicrobial concentrate that takes advantage of the highly effective antimicrobial property of the water-in-oil acetified emulsions. This concentrate can be easily introduced to the processing equipment during oil cleaning procedures.
ABOUT THE INVENTOR
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- Prof. Lynne McLandsborough is the Interim Associate Vice Chancellor for Research and Engagement and Interim Director of the Center for Agriculture, Food and the Envinroment (CAFÉ). Her research interest includes the genetics of Listera sp.biofilm growth, the biological, physical, and chemical aspects of bacterial adhesion, transfer and removal, as well as the antimicrobial delivery systems for cleaning and sanitation. She is also the Director o UMass Food Science Industrial Strategic Alliance and Co-Chair of the UMass Food Science Industrial Advisory Board.
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 23-046
PATENT STATUS:
Patent Pending
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR:
Lynne McLandsborough
CONTACT:
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Primary:
University of Massachusetts Amherst
Date posted:
Feb 8, 2024
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Triazole-rich deoxybenzoin-containing polymers as halogen- and phosphorous-free flame retardants
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Halogen- and phosphorous-free flame-retardant materials
APPLICATIONSTECHNOLOGY DESCRIPTION
The invention takes advantage of … more
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Halogen- and phosphorous-free flame-retardant materials
APPLICATIONSTECHNOLOGY DESCRIPTION
The invention takes advantage of alkyne-azole chemistry to produce impressive non-toxic and safe flame-retardant polymers and additives that can be integrated into industrial processes.
ABOUT THE INVENTOR
Dr. Todd Emrick is a Professor in the Department of Polymer Science and Engineering. He is a prolific inventor and a Fellow of the National Academy of Inventors. His research focuses on synthetic organic/polymer chemistry, functionalization of nanoscale and 2D materials, aqueous polymer assembly and the preparation of polymer-based therapeutics.
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 23-013
PATENT STATUS:
Patent pending
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR:
Dr. Todd Emrick
CONTACT:
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Primary:
University of Massachusetts Amherst
Date posted:
Oct 19, 2023
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ARTIFICIAL NEURONS USING DIFFUSIVE MEMRISTOR
APPLICATIONS
Applications include pattern recognition, machine learning, artificial intelligence, robotics, and other areas where brain-inspired … moreAPPLICATIONS
Applications include pattern recognition, machine learning, artificial intelligence, robotics, and other areas where brain-inspired computing paradigms are beneficial.
APPLICATIONS
ADVANTAGES
Advantages include their low power consumption, high density integration, non-volatility, and compatibility with existing semiconductor fabrication processes. These characteristics make the proposed artificial neuron architecture suitable for large-scale neuromorphic systems and cognitive computing applications.
TECHNOLOGY DESCRIPTION
The invention addresses the need for efficient and scalable artificial neuron designs that can mimic the behavior of biological neurons in neural networks. It aims to provide a solution that allows for fast and energy-efficient information processing and learning capabilities.
The patent describes the use of diffusive memristors as key components in artificial neurons. Memristors are electronic devices that can change their resistance based on the history of applied voltages. Diffusive memristors, in particular, exhibit a gradual and reversible resistance change, making them suitable for emulating the synaptic connections between neurons.
The invention outlines a circuit architecture that integrates diffusive memristors with other electronic components to form artificial neurons. These neurons can receive input signals, perform computation, and produce output signals. The memristors play a crucial role in modulating the strength of the connections between artificial neurons, enabling synaptic plasticity and learning capabilities.
ABOUT THE INVENTOR
Dr. Qiangfei Xia is a professor of Electrical & Computer Engineering at UMass Amherst and head of the Nanodevices and Integrated Systems Laboratory. He received his Ph.D. in Electrical Engineering in 2007 from Princeton University
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 17-036
PATENT STATUS:
US Patent Issued 11,586,864
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR:
Dr. Qiangfei Xia
CONTACT:
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Primary:
University of Massachusetts Amherst
Date posted:
Jun 24, 2023
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CAPACITIVE ARTIFICIAL NEURAL NETWORKS
APPLICATIONS
Applications include pattern recognition, image processing, natural language understanding, robotics, and other fields where … moreAPPLICATIONS
Applications include pattern recognition, image processing, natural language understanding, robotics, and other fields where machine learning and artificial intelligence techniques are applied.
APPLICATIONSTECHNOLOGY DESCRIPTION
The invention introduces a technology that utilizes capacitative components to implement artificial neural networks, enabling advanced computing systems with improved efficiency and performance.
It addresses the need for more efficient and scalable artificial neural network architectures. It aims to provide a solution that allows for faster and more energy-efficient information processing, enabling the development of advanced machine learning and artificial intelligence systems.
The patent describes a novel approach that incorporates capacitative components into the design of artificial neural networks. Capacitors are utilized as key elements in the network's structure, taking advantage of their ability to store and release electrical charge.
The capacitative artificial neural networks (CANNs) outlined in the patent leverage the inherent properties of capacitors to facilitate fast and parallel processing of information. The capacitors store electrical charges that represent synaptic weights, enabling the network to perform computations efficiently.
The invention further describes the integration of CANNs with other components such as transistors, amplifiers, and interconnects to create complete neural network systems. These systems demonstrate improved performance in terms of speed, energy efficiency, and scalability compared to traditional artificial neural network architectures.
ABOUT THE INVENTOR
Dr. Qiangfei Xia is a professor of Electrical & Computer Engineering at UMass Amherst and head of the Nanodevices and Integrated Systems Laboratory. He received his Ph.D. in Electrical Engineering in 2007 from Princeton University
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 18-003
PATENT STATUS:
US Patent Issued 10,740,672
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR:
Dr. Qiangfei Xia
CONTACT:
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Primary:
University of Massachusetts Amherst
Date posted:
Jun 24, 2023
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