Aab Cardiovascular Research Institute (CVRI) researchers are dedicated to understanding how the heart and blood vessels become susceptible to disease. Using state-of-the-art technologies, new treatments and diagnostic tests are being developed and analyzed for potential use in clinical cardiovascular medicine.

The faculty of the CVRI focus on five areas of research in the cardiovascular system.

Vascular and developmental biology
Response to ischemic injury
Electrophysiology and ion channels
Molecular pharmacology and signal transduction
Genetics of cardiovascular disease

The overall goal is to understand how the cardiovascular system develops and responds to physiological and pathological changes. Understanding these processes will provide insight into new therapeutic approaches to treat diseases such as hypertension, coronary artery disease, stroke, and atherosclerosis.

Four areas of research will be developed in the Center for Cardiovascular Research. These areas are vascular and developmental biology; ischemic injury, molecular pharmacology and signal transduction; and genetics of cardiovascular disease. The overall goal is to understand how the cardiovascular system develops and responds to physiological and pathological changes.

A Research Institute of the American Academy of Pediatrics at the University of Rochester. The mission of the Richmond Center is to improve child health by eliminating children's exposure to second hand smoke and tobacco through changing the clinical practice of pediatrics. The vision is that all child healthcare clinicians will be active participants in the elimination of tobacco/SHS exposure of children. With the establishment of the Richmond Center at the AAP, child health clinicians will be provided with the education, training and tools needed to effectively intervene to protect children from the harmful effects of tobacco/SHS.

Advancement of clinical research is a fundamental mission of the AD-CARE program. We participate in a number of national and worldwide studies, offering individuals with memory problems the opportunity to become involved in current research initiatives. Specialists who have expertise in dementia treatment and research direct the day-to-day activities of our clinical studies. We conduct studies concerning:

Early memory problems or cognitive impairment
Diagnostic tools used for Alzheimer's disease
All stages of Alzheimer's disease
Behavioral disturbances in persons with dementia

The University of Rochester Medical Center has been caring for patients with HIV infection since the beginning of the epidemic. Strong Memorial Hospital's AIDS Center gained designation as a center for excellence in HIV/AIDS Care by the New York State Department of Health in 1987. This designation allows for increased services, coordinated care, and a wide range of programs that would otherwise be unavailable.

The AIDS Center is dedicated to providing high quality, comprehensive, multidisciplinary care to persons living with HIV and their families. The Center also offers support systems in both inpatient and outpatient settings. These services are provided across a number of programs.

The Rochester Center for Biomedical Ultrasound (RCBU) was created at the University of Rochester to unite professionals in engineering, medical, and applied science communities at the University of Rochester, Rochester General Hospital, and the Rochester Institute of Technology. Since its founding in 1986, the RCBU has grown over the years to nearly 100 members, with several visiting scientists from locations around the country.

The RCBU provides a unique collaborative environment where researchers can join together to investigate the use of very high frequency sound waves in medical diagnoses and therapy.

The Center's mission encompasses research, education, and innovation.

The Center for Emerging & Innovative Sciences is one of fifteen NYSTAR-sponsored Centers for Advanced Technology devoted to promoting economic development in the greater Rochester region and in New York State. CEIS carries out its mission by supporting the development and transfer of technology to industry for commercialization and by contributing to the education of the next generation of technical leaders.

The Center for Future Health is a multidisciplinary research laboratory where physicians, engineers, and scientists from both academe and industry create advanced medical technology on a personal scale.

Researchers at the Center work together to develop new concepts for consumer-priced, home-based, non-intrusive devices and systems that maintain health and promote wellness worldwide. The Center's industrial partners produce and market these concepts for eldercare, child development, and preventive health monitoring.

The Center's focus on the central role of the individual and on home-based, affordable technology will irreversibly alter the fabric of health care worldwide. By giving individuals greater ownership over their own health, the Center will make the highest quality health care available to every community in the world.

The Brain in Health and Disease - The human brain, with its 100 billion neurons and 100 trillion synapses, can be considered evolution's greatest achievement. Understanding how genes and environment build this extraordinarily complex structure and modulate its function in health and disease is a major focus of modern neuroscience. Approaching this challenge from a variety of directions, the Center for Neural Development and Disease (CNDD) at the University of Rochester Medical Center brings together faculty from diverse departments, including Neurology, Pediatrics, Biomedical Genetics, Emergency Medicine, and Neurobiology and Anatomy, to carry out research directed toward this common goal.

http://www.urmc.rochester.edu/cndd/index.cfm

Our Research Has as its Ultimate Aim the Improvement in Children’s Health
It is becoming increasingly recognized that many childhood diseases originate during embryonic development and several investigators in the Center have a particular interest in the developmental biology of organogenesis.

The Ackerman laboratory is focused on elucidating the genetic causes of congenital diaphragmatic hernia and pulmonary hypoplasia by investigating the normal development of the embryonic diaphragm and lung. The lab also uses forward genetic screening to used to identify novel gene mechanisms for congenital diaphragmatic hernia and other devastating structural birth defects.
The Bulger laboratory investigates the interplay between tissue-specific gene expression and large-scale patterns of chromatin structure with a focus on the beta-globin gene locus. Abnormalities of this locus are the cause of sickle cell disease and thalassemia syndromes, the most common genetic disorders of children world-wide.
The Palis laboratory investigates stem and progenitor cell biology in the context of the developing organism with a particular focus on the blood-forming system. Understanding the developmental origins and regulation of stem cells will provide important insights into tissue maintenance and organ repair for the eventual cell-based treatment of multiple disease states that afflict children.
The human genome project inaugurated a new era of systems biology that deals with the integration of genome wide data to understand complex biological systems at the cellular and subcellular level.

The Steiner laboratory utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development. The laboratory is particularly interested in studying the interactions of specific DNA sequences, DNA binding proteins, and chromatin structure during the differentiation of erythroid cells in both normal and disease states.

The Mariani laboratory takes a genome-based approach, coupled with the generation and analysis of genetically modified animal models, to better understanding the regulation of lung development, focusing upon genes and pathways contributing to chronic lung disease.
The Phizicky/Grayhack and Dumont laboratories are developing new technologies to investigate protein structure and function on a genome-wide scale. Current studies focus on expression, purifiacation, and crystallization of membrane proteins and protein complexes of yeast.
The open research environment within the Center fosters multidisciplinary interactions and engenders an ideal training environment for graduate students and post-doctoral fellows.

The Center for Translational Neuromedicine focuses on the development of new approaches for treating neurological diseases, using cell and gene therapy. Our emphasis is on using these technologies to mobilize endogenous stem and progenitor cells of the adult brain and spinal cord, for purposes of structural repair. In addition, stem cell isolation and transplant strategies are also actively pursued. Our disease targets are those attributable to dysfunction or loss of single cell types, for instance dysmyelinating disease as a paradigm for the use of oligodendrocyte progenitor cells. The principal groups in the Center include Dr. Goldman, whose division focuses on neural stem biology, and Dr. Nedergaard, whose division focuses on astrocytic physiology and pathology.

CVS was founded in 1963 by Robert M. Boynton to bring together scientists from a variety of disciplines with the common goal of pursuing excellence in vision research. CVS consists of more than 25 research laboratories that include faculty from the departments of: Biomedical Engineering, Brain and Cognitive Sciences, Computer Science, Neurobiology and Anatomy, Neurology, Flaum Eye Institute, Optics, and Rochester Center for Brain Imaging.

These laboratories represent a diverse range of studies that span the development of the visual system to the interaction between visual perception and memory. Our investigators employ an equally diverse set of approaches, from molecular genetics and cellular biology to neurophysiology and psychophysics. The Center for Visual Science is affiliated with a number of collaborative research efforts both within and outside the university. These include: Bioengineering Research Partnership and the Center for Computation and the Brain.

The mission of the University of Rochester Clinical and Translational Science Institute is to transform biomedical research by accelerating the application of basic science findings to human health problems, developing clinical solutions, testing efficacy, and implementing interventions at the community level.

Translational biomedical science is the term for multidisciplinary, often team-based research that has as its goal the application of basic science discoveries to improve human health through new diagnostic techniques, new therapies, advances in clinical practice and new community-based interventions. Translational research often begins in the lab with a new discovery in basic biological science which is then “translated” to help solve a problem in human health. It also often begins with a novel observation by an astute clinician, which then spurs new basic research in the lab.

The University of Rochester Clinical and Translational Science Institute promotes this kind of work by creating teams of scientists and physicians to tackle tough problems in human health, and by educating the next generation of translational researchers.

The Clinical Research Center of the University of Rochester Medical Center is a specialized unit funded by the National Center of Research Resources within the National Institutes of Health by a grant to the University (CTSA Grant No. UL1 RR 024160) to support clinical studies. The CRC is a center that provides an optimal setting for medical investigators to conduct safe, controlled, inpatient and outpatient studies of both children and adults. Since 1960, our CRC has been funded to provide the necessary infrastructure for investigators to conduct research studies. Led by the Program Director, Richard T. Moxley III, MD, and the Principal Investigator, Thomas A. Pearson, MD, MPH, PhD, the CRC facilities provide the environment and resources for medical research.

The CRC’s resources include highly trained research personnel in multiple areas: Administration, Nursing, Bionutrition, and Research Subject Advocates. The CRC team helps investigators facilitate the day-to-day research process and assists the research subjects in a supportive and efficient environment.

The CRC is available for faculty investigators, their staff, and medical students working in the URMC setting. In addition, drug company-sponsored clinical trials can be conducted on this unit. Research techniques and experiences, collaboration between investigators, individual growth for investigators and research, and patient care and safety will all be enriched by utilizing the CRC. We are pleased to be available to assist your research team. Medical knowledge continues to grow—let us be a part of your experience.

The URMC Confocal and Conventional Microscopy Core strives to provide UR researchers the ability to obtain high quality imaging data using state-of-the-art microscopy instruments. The Core also aims to be one of the information hubs for UR resources centering around histological processing, imaging, and image processing and to serve as a conduit for communication between imaging researchers on campus.

The Confocal and Conventional Microscopy Core provides Medical Center researchers access to high-end confocal microscopy as well as more conventional brightfield and fluorescence microscopy. The Core provides assistance with all imaging procedures as needed by the investigators. Aid in customizing staining protocols to optimize obtainment of high quality data using Core instruments is also provided. The CCMC provides Medical Center researchers the ability and expertise to obtain high quality imaging-based data from tissue, culture, and materials-based research studies.

The David H. Smith Center for Vaccine Biology and Immunology (CBVI) was formed in 1998 as part of the Aab Institute of Biomedical Sciences. Research in the Center is focused on basic research into immunological mechanisms with a long time goal of helping to design the next generation of vaccines. Investigators in the Center have research areas that focus on many areas of immunology, including T cell activation and differentiation, T cell memory and homing, MHC class II -restricted antigen presentation, T cell responses to pathogenic organisms and T cell-mediated autoimmunity. These varied research programs seek to dissect key regulatory events that control protective and pathogenic immune responses.

http://www.urmc.rochester.edu/cvbi/

The mission of the Flaum Eye Institute is to develop and apply advanced technologies for the preservation, enhancement and restoration of vision through a partnership of academic medicine, private industry, and the community we serve.

The David and Ilene Flaum Eye Institute (FEI) is a growing center for subspecialty eye care,translational vision research, training and community outreach. The FEI was established in 2002 as the University of Rochester Eye Institute, it was renamed in 2009 to reflect the support and advocacy of David and Ilene Flaum. The FEI provides easy access to the most advanced level of care available in the region.

The FEI brings expertise in the areas of:
Comprehensive Eye Care
Cornea Disease
Glaucoma
Oculoplastics, Orbit & Adult Motility
Neuro-Ophthalmology
Pediatric Ophthalmology
Retina
Refractive surgery
Uveitis

The George H. Whipple Lab for Cancer Research was established in 1997 with the recruitment of Dr. Chawnshang Chang as the Founder and current Director. The lab is located in the University of Rochester Medical Center with 7 professors/principal investigators. The lab's interest is mainly in the sex hormones/nuclear receptors and Vitamin D/E effects on the prostate/bladder cancer and other hormone-related diseases.

U.S. News & World Report ranked Golisano Children’s Hospital at the University of Rochester Medical Center as one of America’s Best Children’s Hospitals for Neonatology, Orthopaedics and Neurology and Neurosurgery. Our 124-bed children’s hospital serves as the referral center for upstate New York, surrounding states and Canada. We combine award-winning research, internationally acclaimed education and compassionate care to serve our children and families.

As the only pediatric hospital in the Finger Lakes region, Golisano Children's Hospital cares for 74,000 children each year. The Child Neuromedicine, Pediatric Orthopaedic, and Neonatology programs are ranked nationally and attract children and families from across the country. Several of the hospital's programs are unique to upstate New York, including the allogenic bone marrow transplant program and the pediatric cardiac surgery services' drawing patients from the North Country to northern Pennsylvania.

The mission of the Department of Biomedical Engineering at the University of Rochester is to create and disseminate knowledge in engineering related to biomedical sciences and health care, and to provide students with the foundational knowledge and skills they will need to be leaders in their chosen field.

The Biomedical Engineering Department at the University of Rochester brings together the technical expertise of our Hajim School of Engineering and Applied Sciences with the clinical experience of our University of Rochester Medical Center to establish a cooperative environment that fosters innovations in medicine and healthcare. The BME Department is in close physical proximity to our School of Engineering and Applied Sciences, our world-renowned Medical Center and our internationally acclaimed Institute of Optics. The presence of these Centers and laboratories within close walking distance creates an exciting atmosphere that encourages collaborations across all fields. The University of Rochester Medical Center's new Strategic Plan includes a number of initiatives that involve current and future members of the Department of Biomedical Engineering, including Stem Cell & Regenerative Medicine, Biomedical Imaging & Biomarkers, and Nanomedicine.

The BME Department offers an ABET accredited BS degree program as well as MS, PhD and MD/PhD programs at the graduate level. As a world-class research institution with a commitment to education, we take pride in providing opportunities for both undergraduates and graduate students to become involved in the research process. Students may participate in research in laboratories of one of the 17 primary faculty members in the department or one of the 40 additional faculty members who are affiliated with our graduate program. Research specialties include: Biomechanics, Biomedical Acoustics, Biomedical Nanotechnology, Biomedical Optics, Cell & Tissue Engineering, Medical Imaging, and Neuroengineering.

The mission of the Department of Chemical Engineering at the University of Rochester is to provide students with the initial foundation, knowledge, and skills they will need to become leaders in their professional careers.

The ChemE Department's faculty and students are conducting well-funded research at the forefront of modern chemical engineering. The ChemE Department specialize in applying materials science to tackle grand challenges facing society in the areas of clean energy, biotechnology, and nanotechnology. The ChemE Department offers undergraduate and graduate programs leading to Bachelor's, Master's, and Doctoral degrees.

Specific program objectives include; help students understand and apply math, science, computational, and engineering concepts that constitute the modern intellectual basis for the chemical engineering profession; give students the ability to communicate effectively and work in multidisciplinary teams, taking on leadership roles in industry, academia, or government; Equip students with a strong understanding of environmental, safety, and societal issues facing science and technology and adhere to high ethical standards; Actively engage students in lifelong learning and professional development activities

The ChemE Department takes advantage of the unique resources offered by the University of Rochester to promote the department's mission, including the development of good working relationships with faculty from across the university to facilitate the advising, training and general enrichment of our students' educational experience.