Home Organizations Technologies Needs Capabilities Startups Success stories People

Login Sign Up

University of California, Los Angeles (UCLA)

9members, 0followers

Copyright: A Statistical Atlas Of The Mouse Trunk Region

Name: Arion Xenofon Hadjioannou

Name: Hongkai Wang

Name: UCLA Office of Intellectual Property & Industry Sponsored Research
Email: ncd@research.ucla.edu
Phone: 310.794.0558

Organization Name	University of California, Los Angeles (UCLA)
Institutional ID Number	22109
Technology Tags or Keywords	Research & Drug Discovery Tools Imaging CT MRI Digital imaging Preclinical Medical Molecular Software Scientific/Research
Summary	Small animal imaging modalities, such as micro-CT, micro-PET, and micro-MR, are frequently used in preclinical studies. The laboratory mouse is the most widely used small animal model for cancer, immunology, neurodegenerative, and metabolic disease studies. In order to extract anatomical information from mouse images, it is necessary to perform organ segmentation from the 3D images. Human operator-based processing of 3D images is tedious and subject to bias. Therefore, it is desirable to develop a computerized approach to accomplish this task. A promising solution involves registration of a digital mouse atlas to an acquired image. Organ labeling by the atlas can define organ regions in the mouse image. With this strategy, an atlas can give a more accurate, more reliable, and easier estimation of organ region of a preclinical mouse subject.
Technology Benefit	The statistical atlas is constructed based on many subjects, allowing anatomical variations in the mouse population to be accounted for. Two statistical methods are used to endow the atlas with statistical knowledge of mouse anatomy. These methods account for inter-mouse anatomical variations and shape correlations between different organs. A registration method is designed to register the statistical atlas to preclinical images like micro-CT and micro-PET.
Technology Applications	Preclinical Mouse Study Positron Emission Tomography (PET) and micro-CT CO-registration of anatomical atlas with PET images eliminates the need for PET/CT studies Pharmacology & Toxicology: Accurate estimation of probe uptake into specific atlas-defined organ regions Anatomical CO-registration allows statistical quantification of preclinical micro-CT data between different subjects and between different organs
Technology page URL	http://techtransfer.universityofcalifornia.edu/NCD/22109.html?utm_source=AUTMGTP&utm_medium=webpage&utm_term=ncdid_22109&utm_campaign=TechWebsites
Detailed Technology Description	Researchers at UCLA have developed a novel digital atlas of the mouse trunk region, which contains most of the major organs for preclinical pharmaceutical studies. This computerized atlas is distinct from other anatomical models in that it accounts for anatomical variances in size, age, and strain of mice. The atlas uses two independent statistical methodologies to contour the mouse anatomy and therefore allows highly accurate co-registration of the atlas to preclinical images from either micro-CT or micro-PET.
TTO homepage URL	--
URL to link to documents, images, videos, etc.	--
Additional Information	State Of Development The researchers have developed a functional prototype of the mouse trunk atlas. The atlas has been studied for statistical effectiveness by CO-registration with micro-CT and micro-PET images. Micro-PET testing used three distinct probes. Co-registered images have been color coded in probability maps to confirm the accuracy of organ alignment. Summary Researchers at the University of California, Los Angeles (UCLA) have developed a comprehensive statistical atlas of the mouse trunk anatomy for use in preclinical imaging. Additional Technologies by these Inventors Animal Imaging Chamber for Reproducible Positioning in Repetitive and Cross-platform Imaging New Low-Cost Method for Pre-clinical Animal Imaging Tech ID/UC Case 22109/2011-394-0 Related Cases 2011-394-0

May 24	Emily W. Loughran edited technology High-Strength Wind Turbine Blades And Wings
May 22	Emily W. Loughran edited technology High-Strength Wind Turbine Blades And Wings
May 21	Emily W. Loughran edited technology Disposable World-To-Chip Interface For Digital Microfluidics
May 20	Emily W. Loughran edited technology Disposable World-To-Chip Interface For Digital Microfluidics
May 17	Emily W. Loughran edited technology Disposable World-To-Chip Interface For Digital Microfluidics
May 16	Emily W. Loughran edited technology Disposable World-To-Chip Interface For Digital Microfluidics
May 15	Emily W. Loughran edited technology Disposable World-To-Chip Interface For Digital Microfluidics
May 14	Emily W. Loughran edited technology Disposable World-To-Chip Interface For Digital Microfluidics
May 13	Emily W. Loughran edited technology Disposable World-To-Chip Interface For Digital Microfluidics
May 10	Emily W. Loughran edited technology Disposable World-To-Chip Interface For Digital Microfluidics